At “Common Mechanisms of Neurodegeneration/Microglia in the Brain” a Keystone symposium held last June, researchers from around the globe convened to share their latest research and chart future lines of investigation. They reported major advances. Scientists have, for the first time, created microglia from human stem cells. They have identified essential ion channels that drive microglial motility, essential for the cells to sense their environment and respond to signs of trouble, such as infection or protein aggregates. Scientists reported advances in understanding how microglia mount those responses, and identified roles for the cell surface receptor, TREM2, a genetic risk factor for AD. Read Alzforum’s analysis of some of the major highlights of the meeting.
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