Stress Hormones May Increase Cardiovascular Risks for Shift Workers

Study finds working in shifts associated with elevated levels of stress hormone cortisol

Newswise — Chevy Chase, MD— A recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM) found that shift work at a young age is associated with elevated long-term cortisol levels and increased BMI. Previous studies have shown that long-term elevated cortisol levels lead to increased abdominal obesity, hypertension, diabetes and cardiovascular risk.

Shift work, defined as work performed primarily outside standard working hours, has been associated with increased incidences of obesity, hypertension and insulin resistance, ultimately leading to an increased incidence of cardiovascular disease. This is the first study that shows that working in shifts leads to changes in long-term cortisol levels, suggesting that the stress hormone cortisol might be one of the factors contributing to the increased cardiovascular risks of shift workers.

“Our findings show that cortisol might play an important part in the development of obesity and increased cardiovascular risk for those working in shifts,” said Laura Manenschijn, MD, of Erasmus MC in Rotterdam, The Netherlands and lead author of the study. “Unraveling the role of cortisol in the health problems found in shift workers could result in new approaches to prevent cardiovascular damage in this specific group.”

In this study, researchers collected hair samples from 33 shift workers and 89 day workers. Cortisol was extracted from the hair samples with methanol. Cortisol levels were measured using an ELISA cortisol kit, a diagnostic tool used to detect cortisol concentrations in saliva. Researchers found that long-term cortisol levels were significantly increased in individuals working in shifts, especially in study participants younger than 40 years.

Other researchers working on the study include Rulanda van Kruysbergen of Arbo Unie Nijverdal in The Netherlands and Frank de Jong, Jan Koper and Elisabeth van Rossum of Erasmus MC in Rotterdam, The Netherlands.

The article, “Shift work at young age is associated with elevated long-term cortisol levels and body mass index,” appears in the November 2011 issue of JCEM.

Founded in 1916, The Endocrine Society is the world’s oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society’s membership consists of over 14,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at www.endo-society.org.