Dr. Contractor’s ongoing research is aimed at determining the roles of receptor dependent modulatory processes in determining synaptic and cellular excitability. A large component of his lab’s research has centered upon the role of kainate receptors in the hippocampus, their contribution to excitability in the CA3 microcircuit, and their ultimate influence on developmental processes.
Dr. Contractor’s winning proposal uses single cell patch-clamp recording and two photon imaging to determine how excitability is altered in the CA3 region of the hippocampus in the Dravet Syndrome mouse model. Dr. Contractor will collaborate with the laboratories of Alfred George, M.D., and Jennifer Kearney, Ph.D., in the Department of Pharmacology at Northwestern University. This award will be a first step in establishing preliminary data to support future funding for this collaboration, as there is no other support for these studies. The collaboration between these laboratories will address the critical pieces missing in our current understanding of how mutations in sodium channels in Dravet Syndrome affect excitability and synaptic development in the hippocampus.
The AES Seed Grant Program is intended to foster collaborative interactions between two or more established investigators to make future grants related to epilepsy more competitive for larger awards, and to fuel multi-investigator projects.
About the American Epilepsy SocietyThe American Epilepsy Society (AES) is the largest and most active non-profit medical and scientific society devoted to issues surrounding the epilepsies. Our individual members are professionals engage in both research and clinical care for people with epilepsy from private practice, academia and government. For more than 75 years, AES has been unlocking the potential of the clinical and research community by creating a dynamic global clinical care through the exchange of knowledge, by providing education and by furthering the advancement of the profession.
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