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PIM-1L Kinase Binds to and Inactivates SRPK1: A Biochemical and Molecular Dynamics Study

SR/RS dipeptide repeats vary in both length and position, and are phosphorylated by SR protein kinases (SRPKs). PIM-1L, the long isoform of PIM-1 kinase, the splicing of which has been implicated in acute myeloid leukemia, contains a domain that...
8-Nov-2024 1:05 PM EST Add to Favorites

Polymorphic Positions 349 and 725 of the Autoimmunity-Protective Allotype 10 of ER Aminopeptidase 1 Are Key in Determining Its Unique Enzymatic Properties

ER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses. ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual...
8-Nov-2024 12:45 PM EST Add to Favorites

43rd International Symposium on Physics in Collision

The International Symposium on Physics in Collision, initiated in 1981, is a prominent conference series focused on particle physics. It features invited plenary talks, parallel sessions, and poster presentations, with a strong emphasis on recent...
23-Oct-2024 3:05 AM EDT Add to Favorites


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Founded in July 1961 as a Research Centre for Nuclear Research, Demokritos is today the largest multidisciplinary Research Centre of Greece with approximately 180 Researchers in tenured and tenure-track positions and over 500 Research Personnel working in projects funded mainly by grants from State Funds, the European Union and Private Industries.

The Centre consists of five independent Institutes focusing on different scientific fields. It is governed by the Board of Directors and is supervised by the General Secretariat of Research and Innovation, which is in the Ministry of Development.

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