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Biomolecular condensate ‘molecular putty’ properties found encoded in protein sequence

Scientists at St. Jude Children’s Research Hospital, the State University of New York at Buffalo and Washington University at St. Louis probed how condensates behave like viscoelastic putty and age to more solid states.
2-Jul-2024 12:05 PM EDT Add to Favorites

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Master autoimmune regulator gets by with a little help from its friends

See how St. Jude researchers investigated Foxp3 function as a transcription cofactor in regulatory T cells in immune system activation and suppression.
27-Jun-2024 1:05 PM EDT Add to Favorites

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Children genetically prone to cancer benefit from early standardized surveillance

Scientists at St. Jude Children’s Research Hospital found that, with early screening, they could detect new cancers in pediatric patients with an underlying genetic predisposition at their most treatable stages.
20-Jun-2024 12:05 PM EDT Add to Favorites

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St. Jude scientists solve decades long mystery of NLRC5 sensor function in cell death

Learn about immunology research from the St. Jude laboratory of Thirumala-Devi Kanneganti, PhD, that revealed the function of the NLRC5 innate immune sensor. 
14-Jun-2024 3:40 PM EDT Add to Favorites

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Novel insights into fluorescent ‘dark states’ illuminate ways forward for improved imaging

St. Jude Children’s Research Hospital scientists address decades-long problem in the field of single-molecule fluorescence resonance energy transfer, paving the way for more accurate experiments.
14-Jun-2024 12:05 PM EDT Add to Favorites

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Age is just a number: Immune cell ‘epigenetic clock’ ticks independently of organism lifespan 

See how St. Jude researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old.
12-Jun-2024 10:50 AM EDT Add to Favorites

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Cell-targeting technology allows researchers to isolate neuronal subpopulations and link them to behavioral states

Scientists at St. Jude Children’s Research Hospital designed an intersectional technique for precisely targeting subpopulations of cells and parsing out specific functions.
28-May-2024 12:05 PM EDT Add to Favorites

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Repurposed protease controls important signaling molecule-activating protein

Scientists at St. Jude Children’s Research Hospital reveal the role of iRhom2’s defunct protein-cleaving domain in lifecycle of ADAM17, a key signaling molecule-activating protein.
22-May-2024 11:05 AM EDT Add to Favorites


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The mission of St. Jude Children’s Research Hospital is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a family's ability to pay.

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