Gregory E. Tasian, MD, MSc, MSCE

Gregory E. Tasian, MD, MSc, MSCE

Children's Hospital of Philadelphia

Attending pediatric urologist in the Division of Urology at Children's Hospital of Philadelphia, Cheers for CHOP Chair in Clinical Epidemiology of Pediatric Urological Disease

Expertise: Pediatric Kidney StonesChronic Kidney DiseasePediatric Urology

Gregory E. Tasian, MD, MSc, MSCE, is an attending pediatric urologist in the Division of Urology at Children's Hospital of Philadelphia. He specializes in the surgical and medical management of children with kidney stones.


As a researcher, Tasian is at the forefront of technological innovation and large-scale data analysis in urology. His lab focuses on identifying the underlying causes of kidney stones and how to develop better strategies for reducing kidney stone recurrence throughout a child’s life. He researches the impact of climate change on kidney stone disease. His work predicts increased kidney stone cases due to rising temperatures, highlighting the future healthcare burden even with climate change mitigation efforts. Another notable achievement includes the discovery that oral antibiotics increase the risk of kidney stones.

Tasian is also collaborating with colleagues at the University of Pennsylvania’s Perelman School of Medicine to pioneer the use of machine learning to predict pediatric chronic kidney disease progression. His long-term goal is to improve the lives of children with nephrolithiasis and congenital urologic disease, utilizing advanced research methodologies to enhance diagnosis, treatment, and prevention strategies.


 

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Gregory Tasian, an attending pediatric urologist at CHOP, is leading the PUSH study there. He is concerned by the growing number of teens getting kidney stones, both in his practice and nationally. At this point, there aren’t good population-level numbers for how many adolescents are affected by the condition, but small, regional studies have shown a significant increase over two decades. In particular, Tasian worries about an increasing number of kidney stones in African Americans, among whom the rate is rising at about 5 percent per year. “When you’re talking about an epidemic, this is something in epidemic proportions,” he said. “How quickly this has changed over such a short period of time is really dramatic.”

- CHOP researchers: Why are so many young teens getting kidney stones?

In recent years, hospitals across the country have opened pediatric “stone clinics” to keep up with demand, where children can meet with urologists, nephrologists and nutritionists to get the care they need to treat and prevent future kidney stones. Kidney stones in adults are linked to conditions such as metabolic syndrome, obesity, hypertension and diabetes. "In children, we’re not seeing that," said Dr. Gregory Tasian, a pediatric urologist at Children’s Hospital of Philadelphia. "They’re otherwise healthy and simply come in with their first kidney stone for unclear reasons.” Much of the nephrolithiasis research in children in the U.S. has been led by Tasian and his colleagues and is focused on finding the cause. "Clearly something has changed in our environment that is causing this rapid shift,” he said.

- Kidney stones are rising among children and teens, especially girls, research shows

"As the world becomes warmer through climate change, that is expected to increase the number of stones," Dr. Tasian said.

- More kids are getting kidney stones, research shows. Here's why and how to fight them

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