Feature Channels: Vaccines

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A team of researchers from Bar-Ilan University, in collaboration with researchers from Leiden University (The Netherlands) and Complutense University of Madrid (Spain), has uncovered a previously unknown phenomenon that could revolutionize the way we design materials at the molecular level. By unlocking a transformation between two types of structural defects on the surface of liquid droplets, the research opens new possibilities for controlling molecular patterns with unprecedented precision. This discovery has broad applications across a range of technologies, including vaccine design, the creation of self-assembling structures, and the synthesis of complex nanoparticles.

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Sean Crosson, a Professor Rudolph Hugh Endowed Chair in Michigan State University’s Department of Microbiology, Genetics and Immunology, has been awarded a $2.4 million grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to study the cause of that very disease, Brucella abortus.

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La influenza puede ser una enfermedad desagradable de una semana de duración y un inconveniente para muchas personas, pero puede tener consecuencias graves para los adultos mayores.

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Argonne has received up to $21 million from ARPA-H to use AI and supercomputing in two projects: one targeting hard-to-treat tumors, and another aiming to create vaccines for multiple viral threats, including cancer and pandemics.

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Community partnerships led to a specialized clinic delivering COVID and flu shots to individuals with neurodevelopmental conditions like autism at the MIND Institute.

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A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by WashU Medicine researchers, the trial is the first to report results for this type of vaccine — known as a neoantigen DNA vaccine — for breast cancer patients.

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A la mayoría de la gente no le gusta aplicarse vacunas o inyecciones para recibir tratamientos. Por eso, los investigadores trabajan para crear más medicamentos, como los que se fabrican a partir de ARN mensajero (ARNm), que puedan pulverizarse e inhalarse. Un estudio publicado en la revista Journal of the American Chemical Society informa sobre los avances para hacer posible los medicamentos de ARNm inhalables. Los investigadores indican que la nanopartícula de polímero lipídico, que es estable cuando se nebuliza y libera aerosoles (gotitas líquidas) en los pulmones de ratones de forma satisfactoria, se optimizó para contener el ARNm.

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A study in the Journal of the American Chemical Society reports steps toward making inhalable mRNA medicines a possibility. Researchers outline their improved lipid-polymer nanoparticle for holding mRNA that is stable when nebulized and successfully delivers aerosols (liquid droplets) in mice’s lungs.

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These miniature immune system models — known as human immune organoids — mimic the real-life environment where immune cells learn to recognize and attack harmful invaders and respond to vaccines. Not only are these organoids powerful new tools for studying and observing immune function in cancer, their use is likely to accelerate vaccine development, better predict disease treatment response for patients, and even speed up clinical trials.

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Researchers from Uniformed Services University of the Health Sciences and Duke University have developed a promising vaccine offering strong protection against chlamydia. The study, published in npj Vaccines, shows that a whole-cell vaccine protected mice from infections, helping them clear the bacteria faster and with fewer infections, potentially reviving debates on chlamydia prevention.

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Urgent action is needed, to prevent pneumonia deaths among high-risk groups, particularly children younger than five years and older people, noted the American Thoracic Society and its Forum of International Respiratory Societies (FIRS) partners. New effective preventive interventions are available, but these are still inaccessible in many low- and middle-income countries (LMICs).

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Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. The study team found that the investigational vaccine was generally well tolerated and produced an immune response in most patients. The team described the side effects of the vaccine, showed the highest tolerated dose to date, and presented the immunologic effects of the vaccine. Findings are being presented at the Society for Immunotherapy of Cancer Annual Meeting.

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Whooping cough is making a comeback, and medical providers say the highly contagious bacterial infection that causes severe coughing fits is preventable. During the COVID-19 pandemic, whooping cough, also known as pertussis, declined dramatically.

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A concerning increase in global rates of severe invasive infections becoming resistant to key antibiotics has a team of infectious disease researchers at the Houston Methodist Research Institute studying a recently emerged strain of bacteria called Streptococcus dysgalactiae subspecies equisimilis (SDSE). SDSE infects humans via the skin, throat, gastrointestinal tract and female genital tract to cause infections ranging in severity from strep throat (pharyngitis) to necrotizing fasciitis (flesh-eating disease).

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Liver cancer is the sixth leading cause of cancer death in the U.S. The most common type of liver cancer in adults is hepatocellular carcinoma, and men are more likely to develop HCC than women. It typically develops in people with long-lasting liver disease caused by hepatitis virus infection or cirrhosis. In many cases, liver cancer is a preventable cancer, so raising awareness about prevention is important.

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The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.