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  • Embargo expired:
    18-Jul-2018 2:00 PM EDT

Article ID: 697439

Study Finds Melanoma Biomarkers Predicting Checkpoint Blocker Response

Dana-Farber Cancer Institute

Scientists at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) have identified biomarkers in melanoma that could help tailor immunotherapy treatments to maximize the benefits for patients while reducing the likelihood of severe side effects.

Released:
17-Jul-2018 9:00 AM EDT
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Article ID: 697521

Why Men Might Recover From Flu Faster Than Women

Johns Hopkins Bloomberg School of Public Health

Men may recover more quickly from influenza infections because they produce more of a key lung-healing protein, a study from scientists at Johns Hopkins Bloomberg School of Public Health suggests.

Released:
17-Jul-2018 10:20 AM EDT
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  • Embargo expired:
    12-Jul-2018 2:00 PM EDT

Article ID: 697312

Scientists ID Protein Exploited by Virus Ravaging West Africa

University of California San Diego

New research has uncovered a protein enabling the replication of arenaviruses, lethal pathogens spreading in West Africa. The research identified DDX3 as a key factor through its unexpected ability to dismantle normal human immune system defenses. The study may pave the way to new therapeutic treatments for arenaviruses and hemorrhagic fever.

Released:
11-Jul-2018 2:05 PM EDT
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  • Embargo expired:
    12-Jul-2018 11:00 AM EDT

Article ID: 697196

Guardian of the Cell

Harvard Medical School

Scientists have defined the structure and key features of a human immune-surveillance protein that guards against cancer and bacterial and viral infections The identification of two human-specific variations in the protein closes a critical knowledge gap in immunology and cancer biology The variations explain why the human protein is more precise and more selective than mammalian forms of the protein and why it targets certain types of DNA but ignores others The findings can inform the design of more precisely targeted immune therapies against cancer and a range of immune-mediated diseases

Released:
9-Jul-2018 5:45 PM EDT
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Article ID: 697328

Streck Molecular Kits Detect More Antibiotic Resistance Than Competitors

Streck

Streck, Inc., received great interest in Streck ARM-D® Kits after its poster presentation on improved methodology for detection of antibiotic resistance in Gram-negative bacteria at ECCMID 2018 in Madrid.

Released:
11-Jul-2018 5:05 PM EDT
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Article ID: 697306

Ludwig Cancer Research and Cancer Research Institute Launch Clinical Trial Combining Virotherapy and Immunotherapy to Treat Advanced Colorectal and Ovarian Cancers

Cancer Research Institute and the Ludwig Cancer Research

A clinical trial to evaluate the combination of ONCOS-102, an experimental anti-tumor virotherapy, with the checkpoint blockade antibody IMFINZI® (durvalumab) for advanced ovarian and colorectal cancers has been initiated.

Released:
11-Jul-2018 10:00 AM EDT
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Article ID: 697252

Tip Sheet: Immunotherapy for Deadly Skin Cancer; More Money but No Better Outcome; Yoga and Music for Breast Cancer Therapy; Molecular Discoveries; Caregivers

Fred Hutchinson Cancer Research Center

This month's tip sheet from Fred Hutch includes story ideas about immunotherapy for a deadly type of skin cancer, cancer care that costs twice as much but yields no better outcome, yoga and music therapies for breast cancer and more. To pursue any of these story ideas, please contact the individual listed for each.

Released:
10-Jul-2018 3:25 PM EDT
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Article ID: 697250

UC San Diego Biologists Discover Process That Neutralizes Tumors

University of California San Diego

Researchers discovered an unexpected twist in the battle versus tumors. Researchers have found that some tumor cells display not only a weapon, but also a brake, essentially becoming a neutralizing function. The unexpected mechanism could help determine whether a cancer patient will respond to immunotherapy.

Released:
10-Jul-2018 3:05 PM EDT
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Article ID: 697191

Kimishige Ishizaka, Distinguished Immunologist Who Guided Growth of Nascent La Jolla Institute, Dies

La Jolla Institute for Allergy and Immunology

Dr. Kimishige Ishizaka, discoverer of a novel class of antibodies and the first Scientific Director of the La Jolla Institute for Allergy and Immunology (LJI), has died on July 6 in Yamagata City, Japan. He was 92 years old.

Released:
9-Jul-2018 4:30 PM EDT
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  • Embargo expired:
    9-Jul-2018 11:00 AM EDT

Article ID: 697041

Genome Editing Reduces Cholesterol in Large Animal Model, Laying the Groundwork for In-Human Trials

Perelman School of Medicine at the University of Pennsylvania

Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, the first demonstration of a clinically relevant reduction of gene expression in a large animal model using genome editing. This finding could lead to a possible new approach for treating heart disease patients who do not tolerate PCSK9 inhibitors—drugs that are commonly used to combat high cholesterol.

Released:
5-Jul-2018 1:00 PM EDT
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