Nasal spray may ease rapid heartbeat

Research Highlights:

In a new study, etripamil, a rapid- and short-acting investigational medication formulated to be delivered via nasal spray, restored a normal heart rhythm in less than 30 minutes in most users with intermittent rapid heartbeats, sparing them a trip to the emergency room to receive intravenous medication.
Participants were able to detect when they were experiencing tachycardia (heart rate over 100 beats/minute) and use the medication appropriately and safely.
The self-administered treatment may help the approximately 1 in 300 adults in the U.S. who are diagnosed with tachycardia every year, researchers say. However, the medication is awaiting approval from the U.S. Food and Drug Administration.

Newswise — DALLAS, Sept. 27, 2023 — A fast-acting medication delivered as a nasal spray may someday allow patients with intermittent rapid heartbeats to treat it themselves as soon as they develop symptoms, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association. This new medication is still waiting on approval from the U.S. Food and Drug Administration.

“This is a potential new and exciting option for patients to safely self-treat their rapid heartbeat without direct medical supervision to avoid emergency room visits and medical interventions,” said James E. Ip, M.D., lead author of the study and an associate professor of clinical medicine at Weill Cornell Medicine at New York-Presbyterian Hospital in New York City.

About 1 in 300 people in the United States experience intermittent periods of rapid heartbeat (more than 100 beats per minute, and more typically 150-200 beats per minute) in the lower chambers of the heart, a condition called paroxysmal supraventricular tachycardia.

The standard treatment during an episode is to slow your heart rate by performing physical actions called vagal maneuvers, one of which is done by trying to bear down, achieved by breathing out with your stomach muscles but you don’t let air out of your nose or mouth. These types of actions can make your vagus nerve slow electrical conduction through the atrioventricular (AV) node, which regulates the timing of the electrical pulses to the lower portion of the heart. If the self-administered vagal maneuvers are not effective (which happens about 20-40% of the time), the person should seek immediate treatment of intravenous medication at an emergency room to return the heart rate to normal. In the United States, about 50,000 emergency room visits a year are for paroxysmal supraventricular tachycardia, Ip said.

In a previous study, people with the disorder treated themselves with either etripamil or a placebo nasal spray for a single episode of rapid heartbeat. Participants applied an electrocardiogram (ECG) patch at the onset of symptoms, did a vagal maneuver and self-administered the nasal spray if the rapid heartbeat continued — keeping the ECG patch on for at least five hours. In that study, the first time that etripamil was used without direct supervision, normal heart rhythms were restored within 30 minutes in 54% of patients, compared to 35% with placebo, and the medication was found to be safe and well tolerated. The ECG patch is a wearable heart monitor that has a small device with an adhesive that sticks on the chest skin surface and is wirelessly connected to a cell phone to transmit the ECG data.

All people in that randomized trial were invited to participate in the current open-label study that allowed patients to self-treat with etripamil during multiple episodes of paroxysmal supraventricular tachycardia (PSVT). Of the 169 patients enrolled, 105 self-administered at least one dose of etripamil (70 mg) during the median 232-day study period.

The new study found:

Etripamil restored heart rate to normal within 30 minutes in 60.2% of the 188 verified PSVT episodes, and within an hour in 75.1% of the episodes.
Of the 40 participants who self-treated two episodes, 63.2% responded to the medication within 30 minutes. Nine people (23%) did not convert to a normal heart rate on either episode, and 21 (53%) converted to normal heart rate on both episodes.
Safety was assessed regardless of whether the episode was confirmed by ECG. Thirty-four participants (32.4%) reported one or more side effects from the medication, most commonly mild-to-moderate nasal congestion or discomfort, or a runny nose. There were no serious heart-related adverse events.

”There are no great options for patients to self-treat paroxysmal supraventricular tachycardia, and this condition can cause significant distress and anxiety,” Ip said. “Similar to an albuterol inhaler for asthma patients or an epinephrine pen for patients that have severe allergies or anaphylaxis, etripamil nasal spray may be a great option for people who have paroxysmal supraventricular tachycardia.”

Study details and background:

The study began in Dec. 2018 and ended in Oct. 2020.
Participants were an average age of 58 years old, 62% were women and about 83% were white adults, 8% African American adults, 3% Asian adults, 2% native Hawaiian or Pacific Islander adults and 5% other races.
All participants had been diagnosed with paroxysmal supraventricular tachycardia and had experienced, on average, 9.7 episodes in the previous year. Most were taking long-acting medications to prevent rapid heartbeats. People were excluded from the study if they had certain other heart conditions such as atrial fibrillation.
Participants were good at detecting when they were having rapid heart rhythms, with 92 (87.6%) of them having one or more episodes confirmed by ECG. Verified episodes were used to evaluate the medication’s effectiveness.
For people with atrial fibrillation (rapid and irregular heartbeats from the upper chambers of the heart), etripamil is being investigated for quickly slowing the heart rate down.

Unlike previous studies comparing etripamil to a placebo, this open-label, follow-up study was limited by not having a control group (no one taking a placebo). The study is also limited by only including adults. Etripamil treatment of children ages 6-17 with paroxysmal supraventricular tachycardia is being evaluated in a separate study starting this year. Although the majority of participants in the current study self-identified as white, the researchers expect the results to be generalizable to people in other racial/ethnic groups because previous studies have shown that etripamil’s metabolism and impact on the AV node are similar regardless of race/ethnicity.

Co-authors and their disclosures are listed in the manuscript. The study was funded by Milestone Pharmaceuticals, the manufacturer of etripamil.

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