Observational studies on large populations have linked the acute mental stress caused by earthquakes (2) or the World Cup (3) with increased heart attacks and other adverse cardiac events. In contrast in patients with known coronary heart disease (CHD) and stable angina exercise is generally safe and likely beneficial.
The study, funded by the British Heart Foundation (BHF) and carried out at King’s College London and St Thomas’ Hospital, looked at 15 people with significant CHD and 11 people without significant CHD. The study volunteers underwent tests to trigger mental stress whilst the blood pressure and speed of blood flow inside the coronary arteries supplying blood to the heart were measured.
The researchers saw an increase in heart rate and blood pressure during mental stress testing reflecting an increase in oxygen demand by the heart muscle. Surprisingly in people with CHD blood flow in the coronary arteries did not increase to meet that demand. The researchers saw an increased inability of the blood to flow through the small blood vessels in the heart.
There are 2.3 million people living with CHD in the UK (4) and these findings suggest that, for those people in particular, mental stress is not benign. Now the researchers know how it can affect the heart, studies can be carried out to find treatments to counteract the effect of mental stress and reduce the risk of potentially deadly heart problems.
Dr Satpal Arri, BHF Research Fellow at King’s College London and Cardiology Registrar at Guy’s and St Thomas’ NHS Foundation Trust, who led the study supervised by Professor Simon Redwood, said:
“These preliminary results show a clear association between mental stress and effects on the heart that are particularly concerning for people with coronary heart disease. Currently there are no specific treatments to counteract these effects, although current angina treatments such as beta-blockers, that reduce the body’s stress response, may offer protection. Specific treatments for mental stress could come from this research in the future.
“In the short term, our findings suggest that it’s important that doctors are aware that mental stress may pose a risk for some people with coronary heart disease so they can then advise and treat patients accordingly to minimise that risk.”
Professor Jeremy Pearson, Associate Medical Director at the BHF, which funded the research, said:
“We’ve known for some time, in part through BHF-funded research, that mental stress can have indirect effects on the heart. But this study has shed some light on how mental stress could pose a risk to people with significant coronary heart disease and that it may have a different effect from exercise stress, which, in contrast, can be beneficial.
“Larger scale studies are needed to confirm this finding. However, during Euro 2016 it’s likely that plenty of people will experience some mental stress and even more frustration. These findings emphasise that people with coronary heart disease should do what they can to minimise those stress levels once the tournament kicks off.”
Find out more about the British Cardiovascular Society Conference at http://www.bcs.com/conference.
ENDS
To request interviews or for more information please call the BHF press office on 020 7554 0164 or 07764 290 381 (out of hours) or email [email protected]
Notes to Editors
1) Abstract available here: http://www.bcs.com/abstracts3/marker_view.asp?AbstractID=19522) http://www.ncbi.nlm.nih.gov/pubmed/85521423) http://www.ncbi.nlm.nih.gov/pubmed/182347524) BHF Cardiovascular Disease Statistics 2015. Available online: https://www.bhf.org.uk/research/heart-statistics
About the British Cardiovascular Society (BCS)BCS is the voice for those working in cardiovascular health, science and disease management in the UK; we aim to promote and support both the healthcare professionals who work in cardiology and the patients for whom we want to encourage the best possible treatment. Our members are healthcare professionals, working in the field of cardiovascular health.Find out more at http://www.bcs.com
British Heart FoundationCoronary heart disease is the UK’s single biggest killer. For over 50 years we’ve pioneered research that’s transformed the lives of people living with heart and circulatory conditions. Our work has been central to the discoveries of vital treatments that are changing the fight against heart disease. But so many people still need our help. From babies born with life-threatening heart problems to the many Mums, Dads and Grandparents who survive a heart attack and endure the daily battles of heart failure. Every pound raised, minute of your time and donation to our shops will help make a difference to people’s lives. Find out more at http://www.bhf.org.uk
Guy's and St Thomas' NHS Foundation Trust provides more than 2 million patient contacts in acute and specialist hospital services and community services every year. As one of the biggest NHS trusts in the UK, with an annual turnover of more than £1.3 billion, we employ around 13,650 staff. http://www.guysandstthomas.nhs.uk
Meeting Link: British Cardiovascular Society Conference, Jun-2016
RSS