Sanford Burnham Prebys

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How a protein component of nuclear pore complexes regulates development of blood cells and may contribute to myeloid disorders

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence...
5-Jun-2024 5:05 PM EDT Add to Favorites

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How tumor stiffness alters immune cell behavior to escape destruction

Researchers at Sanford Burnham Prebys, with collaborators, illuminate how the fibrotic tumor microenvironment creates an inhospitable milieu for anti-tumor immunity, not just by creating a physical barrier but through metabolic changes that suppress...
4-Jun-2024 3:05 PM EDT Add to Favorites

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Overlooked lipid connected to ancient cellular pathway with links to cancer

Brooke Emerling, Ph.D., co-director of, and associate professor in, the Cancer Metabolism and Microenvironment Program at Sanford Burnham Prebys, is contributing to a revival of interest in an underappreciated set of enzymes called...
28-May-2024 1:00 PM EDT Add to Favorites

AI tool predicts responses to cancer therapy using information from each cell of the tumor

With more than 200 types of cancer and every cancer individually unique, ongoing efforts to develop precision oncology treatments remain daunting. In a new study published in the journal Nature Cancer, first author Sanju Sinha, Ph.D., at Sanford...
18-Apr-2024 2:05 PM EDT Add to Favorites

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Debanjan Dhar looks at links among liver cancer, heart health and kidney function

As an associate professor at Sanford Burnham Prebys, Dhar focuses on how lifestyle factors such as high-calorie diets, excessive alcohol consumption and minimal exercise—along with genetic predispositions—can lead to problematic changes in the...
17-Apr-2024 3:45 PM EDT Add to Favorites

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Common HIV treatments may aid Alzheimer’s disease patients

Scientists at Sanford Burnham Prebys have now identified promising real-world links between common HIV drugs and a reduced incidence of Alzheimer’s disease. The study, led by Jerold Chun, M.D., Ph.D., was published in Pharmaceuticals.
16-Apr-2024 12:05 PM EDT Add to Favorites

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Tiny brain bubbles carry complete codes

In findings published in Cell Reports, senior author Jerold Chun, M.D., Ph.D., and team also discovered that the biological instructions within these vesicles differed significantly in postmortem brain samples donated from patients suffering from...
9-Apr-2024 11:05 AM EDT Add to Favorites

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What Makes a Pathogen Antibiotic-Resistant?

In a new study, Sanford Burnham Prebys researchers, led by Andrei L. Osterman, Ph.D., combined experimental evolution in a continuous culturing device with whole genome sequencing of evolving cultures to track how two bacterial pathogens acquired...
7-Mar-2024 9:00 AM EST Add to Favorites

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Our Experts on Newswise

Xueqin Sun seeks to illuminate the underlying causes of cancer

As a new assistant professor at Sanford Burnham Prebys faculty, Sun seeks to better understand the genetic and epigenetic underpinnings of cancers, using genome editing technologies, animal and patient-derived models, and other tools to develop more...
13-Mar-2024 9:05 AM EDT

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Sanjeev Ranade wants to get to the heart of congenital disease

Sanjeev S. Ranade, Ph.D., who joined the faculty of Sanford Burnham Prebys this month as an assistant professor in the Development, Aging and Regeneration program, studies how proteins called transcription factors (TFs) specifically control the...
22-Jan-2024 6:00 AM EST

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When T cells and macrophages talk, Kelly Kersten listens

Kelly Kersten, Ph.D., who joined Sanford Burnham Prebys this month as an assistant professor in the Cancer Metabolism and Microenvironment program, studies the interactions between immune cells and their microenvironment to better understand how...
17-Jan-2024 2:05 PM EST

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Shengjie Feng channels the powers of cryogenic electron microscopy

Shengjie Feng, Ph.D. is an expert in cryo-electron microscopy, a Nobel Prize-winning imaging technology capable of creating stop-action movies of proteins and other biomolecules jostling and connecting with each other while mitochondria and other...
16-Jan-2024 12:05 PM EST

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Fighting Against Triple-Negative Breast Cancer

2-Oct-2017 8:00 AM EDT

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Brrrr...it's WINTER. Can Being Cold Really Help You Burn Calories and Slim Down? An #SBP Researcher Weighs In

31-Jan-2017 2:05 PM EST

Could Fake Sugar Cause Real Problems with Your Metabolism? An @SBPdiscovery Researcher Wants to Find Out

7-Nov-2016 8:00 AM EST

To Treat Breast Cancer, Give It a Lifeline

19-Oct-2016 12:05 PM EDT

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About

Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease and advancing scientific discoveries to profoundly impact human health. For over 40 years, our research has produced breakthroughs in cancer, neuroscience, immunology and children’s diseases, and is anchored by our NCI-designated cancer center and advanced drug discovery capabilities. For more information, visit us at SBPdiscovery.org or on Facebook at facebook.com/SBPdiscovery and on Twitter @SBPdiscovery.