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The Brain’s Immune System May Be Key to New Alzheimer’s Treatments

SBP researchers have revealed how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins to restore neurological function. The research suggests boosting TREM2 levels in the brain may prevent or reduce the...
5-Mar-2018 4:00 PM EST Add to Favorites


Controlling Ceramides Could Help Treat Heart Disease

SBP researchers have discovered that accumulation of ceramides—a type of lipid (fat)— plays a crucial role in lipotoxic cardiomyopathy (LCM)—a heart condition that often occurs in patients with diabetes and obesity. The study, published today...
5-Mar-2018 11:00 AM EST Add to Favorites


Novel Genome Platform Reveals New HIV Targets

SBP researchers have developed the first ever high-throughput, genome-scale imaging-based approach to investigate protein stability. The method has been used to identify several previously unknown human proteins that HIV degrades to enhance its...
22-Feb-2018 8:00 AM EST Add to Favorites


Discovery May Advance Neural Stem Cell Treatments for Brain Disorders

New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) reveals a novel gene regulatory system that may advance stem cell therapies and gene-targeting treatments for neurological diseases such as Alzheimer’s disease,...
24-Jan-2018 9:00 AM EST Add to Favorites


Gut Reaction: Repeated Food Poisoning Triggers Chronic Disease

Small bacterial infections that may go unnoticed and which the body easily clears without treatment, such as occurs during mild food poisoning, nevertheless can start a chain of events that leads to chronic inflammation and potentially...
21-Dec-2017 2:00 PM EST Add to Favorites

Researchers Track Muscle Stem Cell Dynamics in Response to Injury and Aging

A new study led by SBP describes the biology behind why muscle stem cells respond differently to aging or injury. The findings, published in Cell Stem Cell, have important implications for the normal wear and tear of aging.
13-Dec-2017 4:35 PM EST Add to Favorites


Insights on How SHARPIN Promotes Cancer Progression

SBP and Technion Institute researchers have SHARPIN-ed their knowledge of how a malicious form of a protein drives the formation of melanoma through modulation of the PRMT5 pathway. The new research was published in The Journal of Clinical...
11-Dec-2017 4:00 PM EST Add to Favorites


Research Suggests New Pathways for Hyperaldosteronism

Scientists have identified a mechanism that explains the development of hyperaldosteronism, a condition in which the adrenal glands produce too much aldosterone, The findings, published in JCI Insight, offer a path for drug discovery to treat the...
7-Dec-2017 9:05 AM EST Add to Favorites

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