Cosimo Commisso, Ph.D.

Cosimo Commisso, Ph.D.

Sanford Burnham Prebys

Director

Expertise: Pancreatic CancerPancreatic Cancer

Cosimo Commisso, Ph.D., studies pancreatic cancer, one of the deadliest cancers. He is particularly interested in how the tumor gets nutrients from its environment, as cutting this fuel supply could stop the cancer’s growth.

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Preventing pancreatic cancer metastasis by keeping cells “sheltered in place”

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that pancreatic cancer metastasis—when tumor cells gain the deadly ability to migrate to new parts of the body—can be suppressed by inhibiting a protein called Slug that regulates cell movement. The study, published in the Journal of Experimental Medicine, also revealed two druggable targets that interact with Slug and hold promise as treatments that may stop the spread of pancreatic cancer.
05-Jun-2020 01:05:22 PM EDT

Scientists identify promising immunotherapy combination for pediatric brain cancer

Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. The discovery, published in Nature Neuroscience, is expected to lead to a clinical trial to test the benefits of the treatment in patients. The findings also hold implications for other cancers that do not respond to immunotherapy.
15-May-2020 12:50:48 PM EDT

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