Algunos virus son capaces de apoderarse de una enzima que supuestamente previene enfermedades autoinmunitarias con el fin de evitar ser detectados. Este descubrimiento de los investigadores de Mayo Clinic y de sus colaboradores se publica en PLOS Biology.
ROCHESTER, Minn. — An enzyme intended to prevent autoimmune disease can be hijacked and used by some viruses to avoid immune detection. That discovery from Mayo Clinic researchers and collaborators appears in PLOS Biology. There's also good news. The same team also defined how much viral genetic material is needed to reverse the process and instead activate the immune system against the virus.
The Myositis Association (TMA), the leading international patient organization dedicated to improving the lives of people affected by myositis, is pleased to announce the appointment of five new members to its Board of Directors.
The Myositis Association (TMA), the leading international patient organization dedicated to improving the lives of people affected by myositis, is pleased to announce the appointment of three new members to its distinguished Medical Advisory Board.
American Autoimmune Related Diseases Association (AARDA) Joins the Global #GivingTuesday Movement. Our financial campaign goal: Raise $5,000 to provide educational programs to people impacted by autoimmune related diseases.
The American Autoimmune and Related Diseases Association is honored to announce the winners of its 2018 Young Investigator Grants
SBP today announced that the first healthy subject has been dosed in a Phase 1 clinical trial evaluating an inflammation-inhibiting biologic that arose from a research collaboration between Eli Lilly and Company (Lilly) and SBP formed in 2015.
A husband and wife suffering from severe toe arthritis are now pain-free and back to their active lifestyle after surgery with a synthetic cartilage implant at Hospital for Special Surgery.
The mechanisms that trigger the elimination of T cells that pose autoimmune dangers work very mechanically via physical forces. Nascent T cells must loosen their grip on human antigens within a reasonable time, in order to advance and defend the body. But if the nascent T cells, thymocytes, grip the human antigens too tightly, the immune cells must die. Here's how the grip of death works.
Autoimmune diseases such as psoriasis more than double the risk of cardiovascular disease. A new study shows that immune cells that arise during autoimmune disease can cause cholesterol to become trapped inside blood vessels.
Scientists at IMBA - Institute of Molecular Biotechnology at the Austrian Academy of Sciences - together with the Boston Children's Hospital at Harvard, demonstrate a completely new way of combating autoimmune diseases and cancer.
Study could transform care for organ transplant recipients
Progentec Diagnostics, Inc. ("Progentec"), a leader in the development of technological innovations in the field of diagnostics, today announced the completion of a second round of funding co-led by i2E and Chicago-based OCA Ventures.
Researchers at UT Southwestern have identified blood-based biomarkers that may help identify those patients at greatest risk of developing autoimmune side effects from the treatment.
Two studies recently published by La Jolla Institute for Immunology (LJI) investigators Patrick Hogan, PhD, and Aparna Gudlur, PhD, report how a calcium-sensing protein called STIM1 signals that it's time to initiate calcium retrieval and then relays that message to its partner, the calcium channel ORAI.
A subset of patients with low-risk breast cancer is highly unlikely to see cancer return following breast conservation surgery but can lower that risk even further with radiation therapy, finds a new long-term clinical trial report. These 12-year follow-up data from the only prospective, randomized trial to compare recurrence outcomes after treatment for low-risk ductal carcinoma in situ (DCIS) were presented last week at the 60th Annual Meeting of the American Society for Radiation Oncology (ASTRO).
Adding radiation therapy or surgery to systemic therapy for stage IV lung cancer patients whose cancer has spread to a limited number of sites can extend overall survival time significantly, according to new results from a multicenter, randomized, controlled phase II study. The findings were presented last week at the 60th Annual Meeting of the American Society for Radiation Oncology (ASTRO).
Could microbes in our guts be sending out the wrong message? Queen’s University researchers have, for the first time, found a specific microbe in the gut that pumps out protein molecules that mimic a human protein, causing the human defence system to turn on its own cells by mistake.
A Weizmann Institute team develops a novel technology for profiling protein turnover and degradation, offering new insight into diagnosis and the molecular basis of autoimmunity, cancer, neurodegeneration, and other disorders
Recurrent lupus nephritis, a severe complication for patients with systemic lupus erythematosus (SLE) with end-stage renal disease who undergo kidney transplant, is happening less often now compared to the past. This positive trend is likely due to improvements in the immunosuppression regimen these patients now receive, according to new research findings presented this week at the 2018 ACR/ARHP Annual Meeting.
The American College of Rheumatology (ACR) announced the 2018 recipients of its Master of the ACR designation, Awards of Distinction, and Distinguished Fellow Award honors during the opening lecture of the 2018 ACR/ARHP Annual Meeting in Chicago. These recognitions are given annually to members who exhibit outstanding contributions to the ACR and the field of rheumatology.
Hematopoietic stem cell transplantation showed benefit in a subset of patients with systemic sclerosis who tend not to improve on immunosuppressive therapies like mycophenolate mofetil, according to new research findings presented this week at the 2018 ACR/ARHP Annual Meeting.
High-dose influenza vaccination substantially improves immune responses against influenza in adults with seropositive rheumatoid arthritis, according to new research findings presented this week at the 2018 ACR/ARHP Annual Meeting .
4th Los Angeles Autoimmune Walk participants raise awareness through song, speech, chant and cheer.
Scientists who performed the largest-ever genetic study of a puzzling type of adult-onset diabetes have uncovered new connections to the two major types of diabetes, offering intriguing insights into more accurate diagnosis and better treatment.
TMA is pleased to announce they have awarded three new myositis research grants.
In the quest to develop a vaccine that triggers the immune system to prevent HIV infection, researchers have focused on identifying and eliciting a particular type of antibody that is capable of neutralizing the virus.
Findings from mouse study suggest organs affected by autoimmune disease suppress immune cells using methods similar to those used by cancer cells to evade detection.
In proof-of-concept experiments, researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. Researchers deliver a therapeutic enzyme via the cellular equivalent of a Trojan Horse, using platelets to protect the key enzyme hidden inside.
In a paper published in the journal Science, researchers have detailed a mechanism that sets the stage for the fate decision that gives rise to two major subsets of effector cells: T follicular helper cells and non-T follicular helper cells, known as Tfh and non-Tfh cells.
Anyone with arthritis can appreciate how useful it would be if scientists could grow cartilage in the lab. To this end, Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko, MD, PhD, collaborated with colleagues at several institutions to provide new insights into how gene activity drives the development of cartilage. Their findings appear today in Nature Communications.
Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus (SLE). The study, which will be published September 5 in the Journal of Experimental Medicine, shows that ACE inhibitors—a class of drugs commonly used to treat hypertension—can block this process in mice and might therefore be used to preserve the memory of lupus patients.
The American College of Rheumatology (ACR) today released the Rheumatic Disease Report Card: Raising the Grade on Rheumatology Care in America, a first-of-its-kind report that evaluates just how difficult it can be to live well with a rheumatic disease in the United States.
The latest research, features and announcements in healthcare in the Healthcare News Source
The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) is honoring Goran Rakocevic, MD, with the 2018 Best Abstract Award for his abstract, Quantitative Clinical and Autoimmune Assessments in Stiff Person Syndrome: Evidence for a Progressive Disorder.
The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease. New multidisciplinary research involving both psychologists and dermatologists from the Perelman School of Medicine at the University of Pennsylvania is the first to examine how common this stigma may be among the general population of the United States as well as among medical students.
TMA hosts its Annual Patient Conference at the Louisville Marriott Downtown on September 6-9. With more than 500 myositis patients and family members in attendance, this conference promises to be the largest in TMA history.
Dr. Lesley Ann Saketkoo, an associate professor of clinical medicine at Tulane University School of Medicine, has been named Doctor of the Year by the Scleroderma Foundation.
Researchers have found that cholesterol-lowering statins may improve the conditions of people with a rare lung disease called autoimmune pulmonary alveolar proteinosis. The research also suggested that two new tests could help diagnose the condition.
Faculty at The University of Texas Health Science Center at Houston (UTHealth) discuss the diagnosis and treatment of scleroderma, an autoimmune disease affecting an estimated 300,000 people in the United States.
Researchers at Hospital for Special Surgery (HSS) have discovered that a type of immune cell known as Langerhans appears to play an important role in photosensitivity, an immune system reaction to sunlight that can trigger severe skin rashes.
The American College of Rheumatology’s Collaborative Initiatives department has received two grants from the Office of Minority Health (OMH) to support the development of programs that aim to increase the recruitment and enrollment in clinical trials of minority populations affected by lupus.
Researchers at Duke Cancer Institute have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury.
7th DC Metro Autoimmune Walk -- Linking Together for a Cure
A research team from Massachusetts Eye and Ear and MIT has shown that immune cells in the eye that developed in response to early exposure to bacteria are a key contributor to progressive vision loss from glaucoma, the second leading cause of irreversible blindness in the world.
Seattle Children’s has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.
Elijah Patino is a happy, healthy seven-year-old now, but it took a while to get there. For much of his life, he had a mysterious disease that made it painful to eat and painful to play. A pediatric immunologist resolved this "diagnostic odyssey" by identifying the molecular cause of this autoimmune condition, then crafted a low-dose immunosuppressive regimen to provide a precise treatment.
Scientists have discovered that in rheumatoid arthritis (RA) patients, lower levels of vitamin D are associated with increased disease severity. Their findings, announced today at the 70th AACC Annual Scientific Meeting & Clinical Lab Expo, indicate that vitamin D supplementation could significantly improve quality of life for RA patients.
This is an announcement about two doctors who received an honorable mention from the Vasculitis Foundation.
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