Researchers found that waist circumference, percentage of body fat, and hemoglobin A1c levels − a test of long-term blood sugar − all improved in diabetic participants who exercised compared to those who did not. And the beneficial effects of exercise were seen whether they participated in aerobics, resistance training, or a combination of the two compared to a control group that did not exercise.
“What we observed is that exercise improves diabetes control regardless of improvement in exercise capacity,” said Dr. Jarett Berry, Associate Professor of Internal Medicine and Clinical Sciences at UT Southwestern, and co-senior author of the study.
Following an exercise training program generally improves fitness. Researchers typically measure fitness by the ability of the respiratory system to exchange carbon dioxide and oxygen. The more you train, the better your ability to take in oxygen.
But a sub-group of exercisers, considered non-responders, are unable to improve their cardiorespiratory fitness levels despite diligent exercise, explained Dr. Ambarish Pandey, a cardiology fellow at UT Southwestern and first author on the study appearing in Diabetes Care. About 30 percent of exercisers are considered non-responders.
Using data from the Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes (HART-D) trial, researchers looked at whether non-responders who exercised saw improvements in their diabetes control.
“We were interested in the relationship between the change in cardiorespiratory fitness, or exercise capacity, and change in metabolic parameters,” said Dr. Berry, a preventive cardiologist and Dedman Family Scholar in Clinical Care.
Researchers divided people into four groups: • Controls, who did not exercise; • Individuals who did aerobic exercise; • Individuals who did resistance training; • Individuals who did a combination of aerobic exercise and resistance training.
The UT Southwestern data analysis found that hemoglobin A1c, waist circumference, and percentage of body fat all improved in the groups that exercised, regardless of whether the participants improved their cardiorespiratory fitness. This outcome was true even for those participants who were fitness non-responders − those whose ability to take in oxygen did not improve.
“This finding suggests that our definition of ‘non-responder’ is too narrow. We need to broaden our understanding of what it means to respond to exercise training,” Dr. Berry said.
The study proposes that exercise-training programs for people with Type 2 diabetes should measure improvements in glycemic control, waist circumference, and percentage of body fat.
Other UT Southwestern researchers who contributed to this study are: Dr. Darren McGuire, Professor of Internal Medicine, who holds the Dallas Heart Ball Chair for Research on Heart Disease in Women; Colby Ayers, Faculty Associate in Clinical Sciences; and Dr. Ian Neeland, Cardiology Fellow. Dr. McGuire reported receiving honoraria for trial leadership and consultation with GlaxoSmithKline, The Medicines Company, Takeda Pharmaceuticals, Novo Nordisk, Orexigen, Cubist, Janssen, Eli Lilly, Bristol Myers Squibb, Astra Zeneca, Boehringer Ingelheim, Merck, Regeneron, Lexicon, and Eisai.
The HART-D study was supported by a grant from the National Institutes of Health.
About UT Southwestern Medical CenterUT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty includes many distinguished members, including six who have been awarded Nobel Prizes since 1985. The faculty of more than 2,700 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to about 92,000 hospitalized patients and oversee approximately 2.1 million outpatient visits a year.
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