Enzyme May Represent New Target for Treating Asthma

Embargoed Until May 20, 9:15 a.m. CT

FOR MORE INFORMATION, CONTACT:
Dacia Morris
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ATS Office 212-315-8620 (until May 16)

Session: B29 Mechanisms for Airway Hyperresponsiveness: From Cell to Organism
Abstract Presentation Time:  Monday, May 20, 9:15 a.m. CT
Location: Ballroom D Four (Level 3), Kay Bailey Hutchison Convention Center Dallas

ENZYME MAY REPRESENT NEW TARGET FOR TREATING ASTHMA

Newswise — ATS 2019, Dallas, TX ─ An enzyme called diacylglycerol kinase zeta (DGKζ) appears to play an important role in suppressing runaway inflammation in asthma and may represent a novel therapeutic target, according to research presented at ATS 2019. The researchers deleted the enzyme in mouse T cells, which drive the immune system, and found that both inflammation and airway hyper-responsiveness, two hallmarks of asthma, were reduced through independent biomolecular mechanisms.

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Brenal Singh, BA
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