Curated News: JAMA

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Released: 27-Oct-2016 5:05 AM EDT
Death vs. Another Hospital Stay: Study Suggests Medicare Should Weigh Them Equally When Paying Hospitals
Michigan Medicine - University of Michigan

A new analysis suggests that Medicare should focus more on how well hospitals do at actually keeping patients alive during the first 30 days after a hospitalization, in addition to how well they do at keeping patients from being readmitted..

20-Oct-2016 1:05 PM EDT
Pregnancy Increases Stroke Risk in Young Women, but Not in Older Women
Columbia University Irving Medical Center

Pregnancy was not found to raise the risk of stroke in older women, but the risk was significantly higher in young women, according to a study from Columbia University Medical Center and NewYork-Presbyterian.

Released: 19-Oct-2016 11:00 AM EDT
Scientists Link Single Gene to Some Cases of Autism Spectrum Disorder
Washington University in St. Louis

Scientists, led by a team of researchers at Washington University School of Medicine in St. Louis, have linked mutations in a single gene to autism in people who have a rare tumor syndrome typically diagnosed in childhood. The findings, in patients with neurofibromatosis type 1 (NF1), may lead to a better understanding of the genetic roots of autism in the wider population.

12-Oct-2016 11:00 AM EDT
New Guidelines for Life-Saving Blood Transfusions Based on Rutgers Research
Rutgers Robert Wood Johnson Medical School

Most patients who need blood transfusions – including those who are critically ill – can be given blood when their hemoglobin drops to a lower level than practiced traditionally, according to AABB, a national association of blood banks that based its recommendation on research led by Rutgers University.

12-Oct-2016 11:00 AM EDT
Better Models Needed to Predict Risk of Atrial Fibrillation From Medical Records
University of Illinois Chicago

In a study published in the journal JAMA Cardiology, Dr. Dawood Darbar, chief of cardiology at the University of Illinois Hospital & Health Sciences System, and colleagues found that risk prediction models for atrial fibrillation developed by investigators on the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) trial, did not accurately predict incidence of the condition when it was applied to the EMRs of a large group of patients.

Released: 11-Oct-2016 1:05 PM EDT
TSRI and STSI Scientists Use ‘Molecular Autopsies’ to Find Clues to Sudden Death
Scripps Research Institute

A study led by scientists at The Scripps Research Institute and the Scripps Translational Science Institute suggests “molecular autopsies” may help detect gene mutations underlying a sudden death. The research, while early, could help doctors alert living family members to hidden health conditions.

Released: 6-Oct-2016 2:05 PM EDT
When Things Go Wrong After Surgery, a Patient’s Fate – and Bills – Can Vary Widely by Hospital, Study Finds
Michigan Medicine - University of Michigan

A new study shows just how much it costs to care for patients who suffer a complication after surgery, and how widely hospitals can vary in their ability to keep patients from suffering, or dying from, the same complications. It reveals that hospitals vary widely – as much as two- or three-fold -- in what they get paid for caring for patients with the same complications from the same operation.

Released: 5-Oct-2016 5:05 PM EDT
Study Compares Treatments for Urinary Incontinence in Women
University of Alabama at Birmingham

Patients using Botox A for urinary incontinence show higher satisfaction with treatment due to greater reduction in bothersome symptoms.

3-Oct-2016 11:00 AM EDT
Family-Centered Pre-Kindergarten Provides a Strong Foundation for Children’s Mental Health and School Success
NYU Langone Health

A family-centered pre-k intervention developed at NYU Langone has a positive, lasting impact on child mental health and academic performance.

Released: 30-Sep-2016 9:05 AM EDT
One Size Should Not Fit All When It Comes to Our Out-of-Pocket Health Care Costs, U-M & Harvard Experts Say
Michigan Medicine - University of Michigan

Rather than charging all patients the same for doctor visits and prescriptions, out-of-pocket costs should be based on how much a specific clinical service improves health, according to two experts who have studied the issue. They recommend specific changes to Medicare and IRS policy to facilitate this.

28-Sep-2016 11:00 AM EDT
New Research Shows HPV Vaccine Reduces Cervical Pre-Cancers In Young Women
University of New Mexico Comprehensive Cancer Center

New research published Sept 29, 2016, in JAMA Oncology shows the HPV vaccine is efficacious in reducing cervical pre-cancers among young women throughout a population. The New Mexico HPV Pap Registry was the data source used in the study. The researchers found that among women who were 15 to 19 years old at the time of a diagnostic cervical biopsy, the incidence rate of cervical abnormalities decreased between 2007 and 2014.

Released: 27-Sep-2016 9:05 PM EDT
Time Window to Help People Who’ve Had a Stroke Longer Than Previously Shown
University of California, Los Angeles (UCLA), Health Sciences

Time is of the essence when getting people stricken with acute ischemic strokes to treatment. And the use of stent retrievers — devices that remove the blood clot like pulling a cork out of a wine bottle Current professional guidelines recommend that stent retrievers be used to remove blood clots from stroke patients within six hours for people to benefit. But new research finds that the procedure has benefits for people up to 7.3 hours following the onset of a stroke.

19-Sep-2016 11:00 AM EDT
Study: African-American Organ Transplant Recipients at Risk for Skin Cancer
Drexel University

Nonwhite transplant recipients, who are at lower risk for developing skin cancer than their white counterparts, should still receive routine, total-body skin examinations, according to new patient data.

20-Sep-2016 9:00 AM EDT
UNC Hospitals’ Quality Improvement Program Leads to Quicker Treatment of STEMI Heart Attacks
University of North Carolina Health Care System

In 2012, UNC Hospitals launched an initiative aimed at reducing the time it takes hospital staff to recognize when a patient is having a STEMI (ST elevation myocardial infarction) heart attack – the sudden and complete blockage of a heart artery – and to begin appropriate treatment. Now, encouraging results from that effort have been published as a research letter in JAMA Cardiology.

Released: 20-Sep-2016 11:05 AM EDT
Feeding Babies Egg and Peanut May Prevent Food Allergy
Imperial College London

Feeding babies egg and peanut may reduce their risk of developing an allergy to the foods, finds a new study.

Released: 19-Sep-2016 6:30 PM EDT
Researchers Identify Better, Cost-Effective Depression Treatment for Teens
Seattle Children's Hospital

Depression can create a huge cost burden on patients and institutions, and for teenagers that includes issues like missed school and the costs of healthcare for families. A new study in JAMA Pediatrics, led by Seattle Children’s Research Institute and Group Health Cooperative, identifies a cost-effective treatment that yields promising results for depressed teens. “We used a collaborative care approach to treat teen depression, which included having a depression care manager who worked with the patient, family and doctors to develop a plan and support the teen in implementing that plan,” said Dr. Laura Richardson, an adolescent medicine physician and researcher at Seattle Children’s.

Released: 16-Sep-2016 12:05 AM EDT
A Nuclear Threat to Heart Patients? U-M Experts Show Impact From Shortage of Radioactive Stress Test Tracer
Michigan Medicine - University of Michigan

Nearly 15 million times a year, heart patients climb onto a treadmill to take a stress test that can reveal blockages in their heart’s blood vessels. But a looming shortage of a crucial short-lived radioactive element means many heart patients could end up getting less-precise stress tests, or more invasive, riskier heart imaging procedures.

Released: 15-Sep-2016 11:05 AM EDT
Mass. Eye and Ear Team Discovers, Successfully Treats New Variant of Antibiotic-Resistant Bacterium
Massachusetts Eye and Ear

Researchers at Massachusetts Eye and Ear have discovered a new mutation in a highly antibiotic-resistant strain of E. coli that resists clearance by the body’s own immune system by inhibiting white blood cells that ordinarily kill and remove bacteria. In a paper published online today in JAMA Ophthalmology, the researchers describe the case that led them to discover the mutation, and offer suggestions for how to recognize and address this particular microbe if encountered in the future.

6-Sep-2016 10:00 AM EDT
Electric Fans May Exacerbate Heat Issues for Seniors, Study Finds
UT Southwestern Medical Center

Using electric fans to relieve high levels of heat and humidity may, surprisingly, have the opposite effect for seniors, a study by UT Southwestern Medical Center heart specialists suggests.

Released: 1-Sep-2016 10:25 AM EDT
Gastric Bypass Is Better Than Other Procedures for Sustainable Weight Loss
Duke Health

Gastric bypass surgery is more effective for weight loss and long-term weight maintenance than are other surgical procedures and non-surgical treatment, according to a study led by researchers at Duke Health and the Durham VA Medical Center.

Released: 29-Aug-2016 5:20 AM EDT
Integrating Mental & Physical Health Services Through Primary Care Teams Results in Better Outcomes & Lower Costs, New Study Finds
Intermountain Medical Center

A major new study in the Journal of the American Medical Association shows that delivering integrated mental and physical healthcare in team-based primary care settings at Intermountain Healthcare results in better clinical outcomes for patients, lower rates of healthcare utilization, and lower costs.

25-Aug-2016 11:10 AM EDT
Researchers Question Process for Reviewing Coverage of ‘Off Label’ Cancer Drug Use
University of North Carolina Health Care System

In a paper published online by the Journal of the American Medical Association, UNC Lineberger Comprehensive Cancer Center physician-researchers raised concerns that there are inconsistencies between the five reference guides, or compendia, that the Centers for Medicare and Medicaid Services uses to determine which drugs it will reimburse for off-label uses in cancer care.

23-Aug-2016 4:05 PM EDT
Study Finds Links Between Physicians Setting Cancer Care Guidelines and Drug Industry
University of North Carolina Health Care System

University of North Carolina LIneberger Comprehensive Cancer Center researchers say the finding of a high prevalence of financial relationships among authors who helped develop a leading set of cancer care guidelines in the United States lays the foundation for future studies looking at whether payments influenced clinical practice or guideline recommendations.

23-Aug-2016 11:05 AM EDT
Amyloid-Related Heart Failure Now Detectable with Imaging Test
Columbia University Irving Medical Center

A type of heart failure caused by a build-up of amyloid can be accurately diagnosed and prognosticated with an imaging technique, eliminating the need for a biopsy, according to a multicenter study.

Released: 23-Aug-2016 12:05 PM EDT
Can the High Cost of Prescription Drugs in the US Be Contained?
Brigham and Women’s Hospital

Special Communication examines sources of high drug prices in the U.S. and possible solutions to reduce unnecessary burdens on patients while maintaining innovation

22-Aug-2016 11:00 AM EDT
After a Fracture, It’s Time to Rethink Medications
Beth Israel Lahey Health

By discouraging the use of medications that can cause dizziness or loss of balance and prescribing medications known to prevent bone loss, clinicians can help patients lower their risk of falls and fractures.

Released: 18-Aug-2016 12:05 PM EDT
How Genomic Sequencing May Be Widening Racial Disparities in Cancer Care
Michigan Medicine - University of Michigan

As scientists learn more about which genetic mutations are driving different types of cancer, they’re targeting treatments to small numbers of patients with the potential for big payoffs in improved outcomes. But even as we learn more about these driver mutations, a new study suggests the science might be leaving racial and ethnic minorities behind.

Released: 16-Aug-2016 2:05 PM EDT
Bone Marrow Transplant Patients Report Better Quality of Life Compared to Peripheral Blood Transplant Recipients From Unrelated Volunteer Donors
Fred Hutchinson Cancer Center

Large, nationwide study finds better psychological well-being, fewer graft vs. host disease symptoms and greater likelihood of returning to work among bone marrow transplant recipients

2-Aug-2016 12:05 PM EDT
Dangerous Chemical Eye Burns Common in Young Children
Johns Hopkins Bloomberg School of Public Health

One- and two-year-old children are at the highest risk of burning their eyes with chemicals, despite the long held belief that working-age adults were the most at risk from this type of severe eye injury, new Johns Hopkins Bloomberg School of Public Health-led research suggests.

26-Jul-2016 1:05 PM EDT
Social Media Linked to More Satisfaction with Breast Cancer Treatment Decisions
Michigan Medicine - University of Michigan

Women who engaged on social media after a breast cancer diagnosis expressed more deliberation about their treatment decision and more satisfaction with the path they chose, a new study finds.

18-Jul-2016 4:30 PM EDT
Buprenorphine Implants May Be Effective Relapse Prevention Tool for Adults with Opioid Dependence
Mount Sinai Health System

While buprenorphine has long been used to treat adults with opioid dependence, its efficacy can be hindered by lack of adherence to daily, sublingual (beneath the tongue) doses of the medication. New research led by the Icahn School of Medicine at Mount Sinai published online today in The Journal of the American Medical Association (JAMA) showed that a higher percentage of stable, opioid-dependent patients given six-month buprenorphine implants remained abstinent compared to patients given the medication sublingually.

Released: 18-Jul-2016 9:05 PM EDT
Study Casts Doubt on Clinical Significance of Gadolinium Brain Deposits
Lawson Health Research Institute

St. Joseph's Hospital - A new study from Lawson Health Research Institute and the Institute for Clinical Evaluative Sciences (ICES) has cast doubt on the clinical significance of brain deposits of gadolinium (a chemical contrast agent commonly used to enhance MRI imaging).

Released: 18-Jul-2016 9:05 PM EDT
Study Casts Doubt on Clinical Significance of Gadolinium Brain Deposits
Lawson Health Research Institute

St. Joseph's Hospital - A new study from Lawson Health Research Institute and the Institute for Clinical Evaluative Sciences (ICES) has cast doubt on the clinical significance of brain deposits of gadolinium (a chemical contrast agent commonly used to enhance MRI imaging).

13-Jul-2016 3:30 PM EDT
Communication Breakdown? Mismatch in Expectations About Prognosis in Advanced Cancer
University of Vermont

A new study in JAMA Oncology finds that most advanced cancer patients report far more optimistic expectations for survival prognosis than their oncologists, due to patients’ misunderstanding of their oncologists’ clinical judgment.

Released: 12-Jul-2016 2:05 PM EDT
Largest HIV Transmission Study Conducted
University of Liverpool

A new study has found that neither gay men nor heterosexual people with HIV transmit the virus to their partner, provided they are on suppressive antiretroviral treatment.

Released: 12-Jul-2016 2:05 PM EDT
Largest HIV Transmission Study Conducted
University of Liverpool

A new study has found that neither gay men nor heterosexual people with HIV transmit the virus to their partner, provided they are on suppressive antiretroviral treatment.

7-Jul-2016 12:05 PM EDT
Study Shows a Rising, but Uneven, Tide of in-Home Care for Disabled Seniors
Michigan Medicine - University of Michigan

More seniors are getting help from family, friends and hired helpers to keep them in their homes, despite disabilities that keep them from total independence, a new study finds. Half of disabled seniors in a long-term study got in-home help in 2012, up 20 percent from the late 1990s.

7-Jul-2016 1:30 PM EDT
Male Circumcision, HIV Treatment Can Significantly Reduce New Infections in African Men
Johns Hopkins Bloomberg School of Public Health

Increasing the number of men who undergo circumcision and increasing the rates at which women with HIV are given antiretroviral therapy (ART) were associated with significant declines in the number of new male HIV infections in rural Ugandan communities, new Johns Hopkins Bloomberg School of Health research suggests.

10-Jul-2016 10:05 PM EDT
Risk of HIV Transmission From Condomless Sex with Virologically Suppressed HIV-Infected Individuals
JAMA - Journal of the American Medical Association

Among nearly 900 serodifferent (one partner is HIV-positive, one is HIV-negative) heterosexual and men who have sex with men couples in which the HIV-positive partner was using suppressive antiretroviral therapy and who reported condomless sex, during a median follow-up of 1.3 years per couple, there were no documented cases of within-couple HIV transmission, according to a study appearing in the July 12 issue of JAMA, an HIV/AIDS theme issue.

10-Jul-2016 10:05 PM EDT
Interventions Do Not Improve Viral Suppression Among Hospitalized Patients with HIV Infection and Substance Use
JAMA - Journal of the American Medical Association

In a study appearing in the July 12 issue of JAMA, an HIV/AIDS theme issue, Lisa R. Metsch, Ph.D., of Columbia University, New York, and colleagues assessed the effect of structured patient navigation (care coordination with case management) interventions with or without financial incentives to improve HIV-l viral suppression rates among hospitalized patients with elevated HIV-1 viral loads and substance use.

10-Jul-2016 10:05 PM EDT
2016 Recommendations for Antiretroviral Drugs for the Treatment and Prevention of HIV Infection in Adults
JAMA - Journal of the American Medical Association

In a report appearing in the July 12 issue of JAMA, an HIV/AIDS theme issue, Huldrych F. Gunthard, M.D., of University Hospital Zurich, Switzerland, and colleagues with the International Antiviral Society-USA panel, updated recommendations for the use of antiretroviral therapy in adults with established HIV infection, including when to start treatment, initial regimens, and changing regimens, along with recommendations for using antiretroviral drugs for preventing HIV among those at risk, including preexposure and postexposure prevention.

10-Jul-2016 10:05 PM EDT
Caregiver Assistance Increases Among Home-Dwelling Functionally Disabled Older Adults
JAMA - Journal of the American Medical Association

In a study appearing in the July 12 issue of JAMA, Claire K. Ankuda, M.D., M.P.H., and Deborah A. Levine, M.D., M.P.H., of the University of Michigan, Ann Arbor, examined trends in caregiving for home-dwelling older adults with functional disability.

Released: 12-Jul-2016 8:00 AM EDT
U.S. Children's Hospitals Vary Greatly in Costs, Practices for Children with Asthma
Children's Hospital of Philadelphia

Children’s hospitals vary greatly in managing inpatients with asthma, according to researchers who analyzed hospital records in a large national database. Even when patients were grouped by characteristics such as age or severity of illness, hospitals differed significantly in inpatient costs, length of stay, and time spent in the intensive care unit (ICU).

8-Jul-2016 10:05 AM EDT
Insurance Mandates Lead to More Children Diagnosed and Treated for Autism Spectrum Disorder, Penn Study Finds
Perelman School of Medicine at the University of Pennsylvania

State mandates requiring commercial health plans to cover the cost of services for children with autism spectrum disorder (ASD) have resulted in an increased number of children being diagnosed and treated for ASD, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The findings will be published in the July 11th issue of JAMA Pediatrics.

6-Jul-2016 8:05 AM EDT
Acupressure Reduced Fatigue in Breast Cancer Survivors
Michigan Medicine - University of Michigan

Acupressure helped reduce persistent fatigue in women who had been treated for breast cancer, a new study finds.

5-Jul-2016 12:00 PM EDT
Marijuana Use Dampens Brain’s Response to Reward Over Time, Study Finds
Michigan Medicine - University of Michigan

Most people would get a little ‘rush’ out of the idea that they’re about to win some money. In fact, if you could look into their brain at that very moment, you’d see activity in the part of the brain that responds to rewards. But for marijuana users, that rush just isn’t as big – and gets smaller over time, a new study finds. And that may open them up to more risk of addiction.

30-Jun-2016 3:00 PM EDT
Despite Increasing Global Legalization of Physician-Assisted Suicide, Use Remains Rare, Penn Study Finds
Perelman School of Medicine at the University of Pennsylvania

Despite increasing legalization of euthanasia and physician-assisted suicide (PAS) worldwide, the practice remains relatively rare and, when carried out, is primarily motivated by psychological factors such as loss of autonomy or enjoyment of life, rather than physical pain. A new comprehensive assessment of data from around the world shows that in areas where they are legal, only 0.3 to 4.6 percent of deaths result from euthanasia or PAS, with more than 70 percent of cases involving patients with cancer. The study also shows that the majority of patients requesting euthanasia or PAS are older, white and well-educated.

Released: 30-Jun-2016 11:05 AM EDT
Women with BRCA1 Gene Mutation at Higher Risk of Deadly Uterine Cancer
Duke Health

Women who carry the BRCA1 gene mutation that dramatically increases their risk of breast and ovarian cancers are also at higher risk for a lethal form of uterine cancer, according to a study led by a Duke Cancer Institute researcher.

Released: 28-Jun-2016 11:00 AM EDT
Latest Research on Physical Therapy in ICU Setting a "Surprising Reversal"
University of Kentucky

In a surprising about-face, researchers have determined that a protocol providing physical therapy to ICU patients did not shorten hospital length of stay. The study, which is the largest to-date, reversed the findings from earlier pilot studies.

Released: 27-Jun-2016 1:35 PM EDT
Gene Hunters Find Rare Inherited Mutations Linked to Bipolar Disorder
Johns Hopkins Medicine

Using so-called next-generation genome sequencing, researchers at Johns Hopkins have identified 84 potential inherited gene mutations that may contribute to the most severe forms of bipolar disorder. About 5.6 million Americans are estimated to have bipolar disorder.



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