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Rewriting the Book on Chemo-Resistant Cancers with a DNA Library

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KU Cancer Center researcher is finding out why ovarian cancer is resistant to certain types of chemo to eventually identify a different drug target.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 1-Jul-2015 12:00 PM EDT

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Colon Cancer Genes Step Back to Go Forward

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Weizmann Institute studies are revealing a complex picture of colon cancer progression in which certain genes that drive tumor growth in the earlier stages get suppressed in later stages – taking a step back to move forward. This pause could provide an opportunity for researchers to intervene in the metastasis, or provide a means of early detection.

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UW Team Programs Solitary Yeast Cells to Say ‘Hello’ to One Another

University of Washington researchers have used a plant hormone to produce cell-to-cell communication in baker's yeast -- a first step in learning to build multicellular organisms or artificial organs from scratch.

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Small RNAs Found to Play Important Roles in Memory Formation

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Scientists from the Florida campus of The Scripps Research Institute have found that a type of genetic material called “microRNA” plays surprisingly different roles in the formation of memory in animal models. In some cases, these RNAs increase memory, while others decrease it.

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New Family of Small RNAs Boosts Cell Proliferation in Cancer

Rather than cellular trash, half of a transfer RNA (tRNA) molecule appears to actively spur cell proliferation in breast and prostate cancers, suggesting a new role for tRNA and a possible target for a new class of therapy.

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Pinpointing Mutations in a Relapsed Children's Cancer May Lead to Improved Treatments

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Researchers studying the pediatric cancer neuroblastoma have detailed how cancer-driving mutations evolve during chemotherapy, and they hope to exploit this knowledge to design better treatments for children.

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Genes Leave Some Kids Prone to Weakness in Wrist Bones

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Pediatric researchers have discovered gene locations affecting bone strength in wrist bones, the most common site for fractures in children. Children with these genetic variants could especially benefit from activities and diets promoting bone strength.

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Braking Mechanism Identified for Cell Growth Pathway Linked to Several Cancers

Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role in controlling organ size, cell proliferation and cell death.

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UNC Researchers Develop Innovative Gene Transfer-Based Treatment Approach

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University of North Carolina (UNC) School of Medicine researchers have developed an innovative, experimental gene transfer-based treatment for children with giant axonal neuropathy (GAN).