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New Grant Will Help Iowa State University Researchers to Explore Genetics of Stress Resistance in Corn

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A $2.1 million grant from the National Science Foundation will help ISU plant scientists build a better understanding of how corn plants deal with stress conditions. The research will focus on a delicate but vital process in plant cells called protein folding.

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Genetic Risk Factors of Disparate Diseases Share Similar Biological Underpinnings

The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets.

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Gene Therapy Shows Long-Term Benefit for Treating Rare Blindness

Pioneering gene therapy has restored some vision to patients with a rare form of genetic blindness for as long as four years, raising hopes it could be used to cure common causes of vision loss, new University of Oxford research published today shows.

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Gene Therapy Halts Progression of Pulmonary Hypertension in a Large Animal Pre-Clinical Study

Scientists have used a novel gene therapy to halt the progression of pulmonary hypertension, a form of high blood pressure in the lung blood vessels that is linked to heart failure.

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Gut Bacteria May Predict Risk of Life-Threatening Infections Following Chemotherapy

Study could help physicians choose care path for some cancer patients.

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RNA Splicing Mutations Play Major Role in Genetic Variation and Disease

RNA splicing is a major underlying factor that links mutations to complex traits and diseases, according to an exhaustive analysis of gene expression in whole genome and cell line data by scientists from the University of Chicago and Stanford.

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Gut Bacteria May Predict Risk of Life-Threatening Infections Following Chemotherapy

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A new study led by researchers at the University of Minnesota and Nantes University Hospital in France shows that the bacteria in people’s gut may predict their risk of life-threatening blood infections following high-dose chemotherapy.

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Experimental Drug Cancels Effect From Key Intellectual Disability Gene in Mice

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A University of Wisconsin-Madison researcher who studies the most common genetic intellectual disability has used an experimental drug to reverse — in mice — damage from the mutation that causes the syndrome. The condition, called fragile X, has devastating effects on intellectual abilities.

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Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source

Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source

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Fermentation Festival Leads to Rapid Response System at UC San Diego Center for Microbiome Innovation

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While technological advances have made it easier to map our microbiomes and metabolomes, these studies typically take too long for that data to be medically useful. Researchers at the University of California San Diego Center for Microbiome Innovation used the 2016 San Diego Fermentation Festival as a test case for a novel rapid response system. In the study, published in mSystems, the team collected samples, analyzed data and reported conclusions in an unprecedented 48 hours.

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Centennial Awards Honor Outstanding GENETICS Articles

The Genetics Society of America (GSA) and the Editorial Board of the journal GENETICS are pleased to announce the winners of the first Centennial Award for outstanding articles published in GENETICS in 2015. The awards were inaugurated just this year in celebration of the 100th anniversary of GENETICS. Three exceptional articles are recognized from three categories: quantitative genetics, molecular genetics, and population and evolutionary genetics. Prizes for the lead authors of each article include subsidized attendance at The Allied Genetics Conference, an integrated GSA meeting that brings together researchers from the C. elegans, ciliate, Drosophila, mouse, yeast, zebrafish, and population, evolutionary, & quantitative genetics communities.

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GI Problems in Autism May Originate in Genes, Study Suggests

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Columbia University researchers have found evidence in mice that, for some types of autism, gastrointestinal problems may originate from the same genetic changes that lead to the behavioral and social characteristics of the condition.

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Foxes on One of California’s Channel Islands Have Least Genetic Variation of All Wild Animals

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UCLA biologists report in a new study that a species of foxes living on six of California’s Channel Islands have a surprising absence of genetic variation. The research, published today in the Cell Press journal Current Biology, provides a complete genome sequence for a small population of the endangered animals, which have been confined to the islands for thousands of years.

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Missing Links Brewed in Primordial Puddles?

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How easily did life arise on Earth, how likely is it on other planets? A new experiment strongly supports the idea that very early life coding molecules, ancestors of RNA and DNA, arose in primordial puddles with relative ease and speed, and not necessarily just in rarer fiery cataclysms.

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UMMS Scientists Identify Genes That Control Smooth Muscle Contraction

Researchers at UMass Medical School have identified a new molecular pathway critical for maintaining the smooth muscle tone that allows the passage of materials through the digestive system. This finding, based on studying calcium ion-controlled pathways in mice, may lead to new treatments for a host of digestive disorders ranging from common gastroesophageal reflux disease (GERD), to swallowing disorders, incontinence and pancreatitis. Details of the study were published in Nature Communications.

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DNA Barcodes Gone Wild

A team of researchers at Sinai Health System's Lunenfeld-Tanenbaum Research Institute (LTRI) and University of Toronto's Donnelly Centre has developed a new technology that can stitch together DNA barcodes inside a cell to simultaneously search amongst millions of protein pairs for protein interactions. The paper will be published today in the journal Molecular Systems Biology.

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Columbia Engineering-Led Team Advances Single Molecule Electronic DNA Sequencing

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Columbia Engineering-led team reports achieving real-time single molecule electronic DNA sequencing at single-base resolution using a protein nanopore array. The team includes researchers from Columbia University, Genia Technologies (Roche), Harvard University, and the National Institute of Standards and Technology. The work sets the stage for revolutionary, cost-effective genetic diagnostic platforms with unprecedented potential for precision medicine. (PNAS, 4/18/2016)

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Researchers Identify New Mechanism to Target ‘Undruggable’ Cancer Gene

RAS genes are mutated in more than 30 percent of human cancers and represent one of the most sought-after cancer targets for drug developers. However, this goal has been elusive because of the absence of any drug-binding pockets in the mutant RAS protein. A new study published in the April 20 issue of the journal Cell by researchers at the Icahn School of Medicine at Mount Sinai led by E. Premkumar Reddy, PhD, has identified a new mechanism for targeting this important cancer gene.

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Wellderly Study Suggests Link Between Genes That Protect Against Cognitive Decline and Overall Healthy Aging

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An eight-year-long accrual and analysis of the whole genome sequences of healthy elderly people, or “Wellderly,” has revealed a higher-than-normal presence of genetic variants offering protection from cognitive decline, researchers from the Scripps Translation Science Institute reported.

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HIV Infection Prematurely Ages People by an Average of Five Years

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Thanks to combination antiretroviral therapies, many people with HIV can expect to live decades after being infected. Yet doctors have observed these patients often show signs of premature aging. Researchers at University of California San Diego School of Medicine and the University of Nebraska Medical Center have applied a highly accurate biomarker to measure just how much HIV infection ages people at the cellular level — an average of almost five years.