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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 3-Aug-2015 3:00 PM EDT

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Key Gene Found to Drive Kidney Disease Severity

Patients with higher levels of a key protein are at greater risk for severe kidney disease

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Depressed Females Have Over-Active Glutamate Receptor Gene

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Numerous genes that regulate the activity of a neurotransmitter in the brain have been found to be abundant in brain tissue of depressed females, according to research at the University of Illinois at Chicago.

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Cell Aging Slowed by Putting Brakes on Noisy Transcription

Working with yeast and worms, researchers found that incorrect gene expression is a hallmark of aged cells and that reducing such “noise” extends lifespan in these organisms.

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Researchers Resurrect Ancient Viruses in Hopes of Improving Gene Therapy

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Researchers at Massachusetts Eye and Ear and Schepens Eye Research Institute have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina. This discovery, published July 30 in Cell Reports, could potentially be used to design gene therapies that are not only safer and more potent than therapies currently available, but may also help a greater number of patients.

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Genetic Tug of War in the Brain Influences Behavior

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Researchers at the University of Utah School of Medicine report that a nuanced, targeted version of parental control over gene expression, is the method of choice over classic genomic imprinting. Published in Cell Reports, so-called noncanonical imprinting is particularly prevalent in the brain, and skews the genetic message in subpopulations of cells so that mom, or dad, has a stronger say. The mechanism can influence offspring behavior, and because it is observed more frequently than classic imprinting, appears to be preferred.

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Blocking a Gene Reduces Fat

By blocking the expression of a certain gene in patients, University of Montreal researchers have contributed to the demonstration of great decreases in the concentration of triglycerides in their blood, even in various severe forms of hypertriglyceridemia and regardless of the base values or the treatment the patient usually receives.

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Next Generation Gene Therapy for Fanconi Anemia Disorder Using CRISPR-Cas9 Gene Editing Technology–-Does This Approach Open Doors for Treating Other Rare Diseases?

Jakub Tolar, M.D., Ph.D., discusses how gene therapy, specifically gene editing technology called CRISPR-Cas9 signals hope for Fanconi anemia and other blood diseases.

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Long Telomere Length Associated with Increased Lung Cancer Risk

A large-scale genetic study of the links between telomere length and risk for five common cancers finds that long telomeres are associated with an increased risk of lung adenocarcinoma. No significant associations between telomere length and other cancer types or subtypes were observed.

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Scientists Identify Gene Vital for Rebuilding Intestine After Cancer Treatment

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Scientists at the UNC School of Medicine and the UNC Lineberger Comprehensive Cancer Center found that a rare type of stem cell is immune to radiation damage thanks to high levels of a gene called Sox9.