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Medicine

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non-Hodgkin’s lymphoma, B Cells

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 3-Oct-2016 9:00 AM EDT

Medicine

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triple-negative breast cancer, Precision Medicine, fusion genes, genomic analysis, Breast Cancer, Breast Cancer Awareness Month, Val Skinner, Rutgers University, New Jersey

Taking Aim at Triple-Negative Breast Cancer

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Rutgers Cancer Institute of New Jersey researchers in the Precision Medicine Program aim to validate a new genomic sequencing approach that may help identify a sub-set of triple-negative breast cancers. The work is supported by a grant from the Val Skinner Foundation.

Science

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Scientists Discover 3.8 Million Year-Old Proteins

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A team of scientists has uncovered protein fragments dating back 3.8 million years—a discovery that will enhance future understanding of ancient organisms, including human ancestors.

Science

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Oncology, Molecular Medicine

Dr. Mingzhao Xing Presents the Paul Starr Award Lecture

The recipient of the 2016 American Thyroid Association (ATA) Paul Starr Award Lecture is Mingzhao Xing, M.D., Ph.D., Professor of Medicine, Oncology, and Cellular and Molecular Medicine at Johns Hopkins University School of Medicine, Baltimore, MD. Dr. Xing delivered The Paul Starr Award Lecture, entitled "BRAF in Prognostication of Thyroid Cancer -- Where Are We Now?" at the ATA's 86th Annual Meeting, September 21-25, 2016, in Denver, Colorado.

Science

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Self-Charging Fish Tags, A Promising Alternative to Silicon, Hints About Color of Extinct Animals, and More in the DOE Science News Source

Click here to go directly to the DOE Science News Source

Science

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World's Most Sensitive Dark Matter Detector, What to Expect From the Coming Quantum Era and More in the Physics News Source Sponsored by AIP

Click here to go directly to the Physics News Source Sponsored by AIP.

Medicine

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Ut Southwestern, utsw, Ut Southwestern Medical Center, Rett Syndrome, Brain Research, Nature Neuroscience, Autism Spectrum Disorder (ASD), Autism Spectrum Disorder, Autism

Study: Gene Regulation in Brain May Explain Repetitive Behaviors in Rett Syndrome Patients

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Naomi was diagnosed at age 2 with Rett syndrome, a rare, debilitating disease in which patients progressively lose brain function and the ability to walk. While she laughs, smiles and toddles around like most 3-year-olds, Naomi’s repetitive hand behaviors offer clues to her condition.

Medicine

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genetic

Landmark Genetic Interaction Map Reveals the Networks of Cellular Life

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A global genetic interaction map is revolutionizing how genes are being studied. A new study is no longer looking at genes as loners, but instead as a social network of the body, interacting in groups. The new approach may ultimately change our understanding of the genetic roots of diseases.

Medicine

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Childhood Cancer, Leukemia, Pediatric Cancer, pediatric leukemia, Cancer Research

Identical 5-Year-Old Twins with Identical Cancers

These twin brothers are experiencing the unimaginable together – battling cancer.

Medicine

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American Society of Human Genetics, Center for Individualized Medicine, Mayo Clinic Biomedical Ethics Program

American Society of Human Genetics and Mayo Clinic Launch Educational Collaboration

BETHESDA, Md., and ROCHESTER, Minn. — The American Society of Human Genetics (ASHG) and Mayo Clinic Center for Individualized Medicine (CIM) announced today a formal collaboration under which the two organizations will facilitate the use of genomics in medicine through the education of health professionals.

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One Single Biopsy Not Sufficient to Guide Treatment Decisions in Prostate Cancer

Molecular composition of multiple tumors shows genomic differences.

Medicine

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Smallest-Reported Artificial Virus Could Help Advance Gene Therapy

Gene therapy is a kind of experimental treatment that is designed to fix faulty genetic material and help a patient fight off or recover from a disease. Now scientists have engineered the smallest-reported virus-like shell that can self-assemble. It could someday carry potentially therapeutic DNA or RNA and transfer it to human cells. The report appears in the Journal of the American Chemical Society.

Medicine

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Genetics, DNA, Genetic Variant

Scientists Discover Distant DNA Working Together to Affect Disease Risk

New research out of Case Western Reserve University School of Medicine suggests the 3-D structure DNA forms as it crams into cells may provide an additional layer of gene control.

Medicine

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induced pluripotent stem (iPS) cells, Reprogramming, Bromodomains, BET bromodomains, JQ1, Stem Cells

Removing Cellular Bookmarks Smooths the Path to Stem Cells

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Cells use specific proteins that help the cell remember what collection of genes needs to be turned on again after cell division. Removing these transcriptional bookmarks may be a key to better reprogramming of human fibroblasts to create induced pluripotent stem cells, or iPSCs.

Science

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Whitehead Institute, Rudolf Jaenisch, Methylation, Inherited, Imprinted, Dynamic, Aging Brain, Neural Cells

Inherited Parental Methylation Shifts Over Time, May Have Functional Effects in the Brain and Other Tissues

Inherited methylation—a form of epigenetic regulation passed down from parents to offspring—is far more dynamic than previously thought and may contribute to changes in the brain and other tissues over time. This finding by Whitehead Institute scientists challenges current understandings of gene regulation via methylation, from development through adulthood.

Medicine

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Alzheimer, alzheimer disease, Neurology, Brain, Gene

Genetic ‘Switch’ Identified as Potential Target for Alzheimer’s Disease

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A team at the MRC Clinical Sciences Centre (CSC), based at Imperial College London, has found an important part of the machinery that switches on a gene known to protect against Alzheimer’s Disease.

Medicine

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pediatric neurology, Childhood Epilepsy, severe epileptic encephalopathy, Genetics, Precision Medicine, Pediatrics

Gene Discovery in Severe Epilepsy May Offer Clues to Unique Personalized Therapies

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An international team of researchers who discovered a new gene disorder that causes severe childhood epilepsy leveraged that finding to reduce seizures in two children. The collaborators’ case report reflects the potential of precision medicine--applying basic science knowledge to individualize treatment to a patient’s unique genetic profile

Medicine

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Cystic Fibrosis, Lung Disease, Infection, Gene Therapy

Gene Therapy for Cystic Fibrosis Lung Disease

Two new studies from the University of Iowa suggest that gene therapy may be a viable approach for treating or preventing lung disease caused by cystic fibrosis (CF).

Medicine

Science

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epigenetic marks , epigenomes, epigentics, Embryo Development

Ludwig Researchers Solve a Mystery of Early Embryonic Development

A Ludwig Cancer Research study published in the current issue of Nature reports a novel technique to map specific chemical (or “epigenetic”) modifications made to the protein packaging of DNA using a small population of cells. Such epigenetic marks play a central role in the regulation of the genome’s expression.

Science

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case western resserve university

An Expanded Genetic Code Is Shown Phototoxic to Cells

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Scientists found that the synthetic bases used to increase the number of DNA bases from the four that occur naturally in all organisms to six, also makes cells so sensitive to near-visible ultraviolet light that the light becomes toxic to cells.







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