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Life's Extremists May Be an Untapped Source of Antibacterial Drugs

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Life's extremists, a family of microbes called Archaea, may be an untapped source of new antibacterial drugs. That conclusion arises from the discovery of the first antibacterial gene in this ancient lineage.

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TSRI Researchers Find How Mutant Gene Can Cause Deafness

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Scientists at The Scripps Research Institute (TSRI) have discovered how one gene is essential to hearing, uncovering a cause of deafness and suggesting new avenues for therapies.

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Moffitt Cancer Center Researchers Use Evolutionary Principles to Model Cancer Mutations, Discover Potential Therapeutic Targets

Moffitt Cancer Center researchers are taking a unique approach to understanding and investigating cancer by utilizing evolutionary principles and computational modeling to examine the role of specific genetic mutations in the Darwinian struggle among tumor and normal cells during cancer growth.

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Panel-Based Genetic Diagnostic Testing for Inherited Eye Diseases Is Highly Accurate and More Sensitive Than Exome Sequencing

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Investigators at Massachusetts Eye and Ear reported the development and characterization of a comprehensive genetic test for inherited eye disorders in the online version of the Nature journal Genetics In Medicine today.

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Gene Therapy Provides Safe, Long-Term Relief for Patients with Severe Hemophilia B

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Gene therapy developed at St. Jude Children’s Research Hospital, University College London (UCL) and the Royal Free Hospital has transformed life for men with a severe form of hemophilia B by providing a safe, reliable source of the blood clotting protein Factor IX that has allowed some to adopt a more active lifestyle, researchers reported. The results appear in the November 20 edition of The New England Journal of Medicine.

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Of Mice, Not Men

For more than a century, the laboratory mouse has stood in for humans in experiments ranging from deciphering disease and brain function to explaining social behaviors and the nature of obesity. The small rodent has proven to be an indispensable biological tool, the basis for decades of profound scientific discovery and medical progress.

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New Understanding of Genetic Replication Could Help in the Fight Against Cancer

A new line of research from a team at Florida State University is pushing the limits on what the world knows about how human genetic material is replicated and what that means for people with diseases where the replication process is disrupted, such as cancer.

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Scientists Map Mouse Genome's 'Mission Control Centers'

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An international team reports on their cataloguing of the DNA regulatory regions throughout the mouse genome. Their results suggests why studies in mice cannot always be reproduced in humans. They also shed light on the function of DNA’s regulatory regions, which are often to blame for common chronic human diseases.

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Genetic Testing for Personalized Nutrition Leads to Better Outcomes

Personalized dietary advice based on a person’s genetic makeup improves eating habits compared to current “one-size-fits-all” dietary recommendations, says a University of Toronto researcher.

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Pumping Zinc

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Dr. Maya Schuldiner’s lab has identified an unusual cellular mechanism – a two-part zinc pump – that is faulty in some types of Alzheimer’s. While it’s not yet clear how the finding links to Alzheimer’s, it does offer new directions for investigating the causes of the disease.

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