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Opening the Entry Gate for DNA Replication

In a study published today in Genes & Development, Dr Christian Speck from the MRC Clinical Sciences Centre’s DNA Replication group, in collaboration with Brookhaven National Laboratory (BNL), New York, reveal the intricate mechanisms involved in the enzyme that governs DNA duplication during cell division.

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Key to Aging Immune System Is Discovered

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The immune system ages and weakens with time, making the elderly prone to life-threatening infection and other maladies, and a UC San Francisco research team now has discovered a reason why.

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Same Cancer, Different Time Zone

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Just as no two people possess the same genetic makeup, a recent study has shown that no two single tumor cells in breast cancer patients have an identical genome. In fact, depending on the tumor cell, they grow at dramatically different speeds, according to a study led by Nicholas Navin, Ph.D., assistant professor in the Department of Genetics at The University of Texas M.D. Anderson Cancer Center in Houston.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 3-Aug-2014 1:00 PM EDT

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Brain Response to Appetizing Food Cues Varies among Obese People

People who have the most common genetic mutation linked to obesity respond differently to pictures of appetizing foods than overweight or obese people who do not have the genetic mutation, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).

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Researchers to Study Hereditary Breast Cancer to Find BRCA1 Treatment Option

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People with a BRCA1 gene mutation are at much higher risk for breast cancer, but no treatments exist to specifically target this problem. Researchers will use structural biology tools to better understand this difficult-to-treat hereditary cancer.

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Genetic Test Helps Predict Which Children with Kidney Disease Will Respond to Standard Therapy

• Among children with sporadic nephrotic syndrome, genetic mutations in the kidney’s filtration barrier were frequently linked with a lack of response to immunosuppressive treatments. • The genetic test was even more predictive than a kidney biopsy for identifying children who would not benefit from immunosuppressive therapies.

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Scientists Discover Genetic Switch That Can Prevent Peripheral Vascular Disease in Mice

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Millions of people in the United States have a circulatory problem of the legs called peripheral vascular disease. It can be painful and may even require surgery in serious cases. This disease can lead to severe skeletal muscle wasting and, in turn, limb amputation.

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Researchers Create the First Model of the DNA 'Replication Fork'

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Human cells make new copies of their DNA billions of times each day, a crucial process upon which life itself depends. However, scientists do not fully understand how cells unzip the double-stranded DNA molecule before replicating both halves of it. New work at Rockefeller may help change that.

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Study Finds Potential Genetic Link Between Epilepsy and Neurodegenerative Disorders

A new University of Iowa study, published online July 14 in the Proceedings of the National Academy of Sciences, reveals a potential link between epilepsy and neurodegenerative disorders.

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