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NYIT Expert Predicts Growth in Demand for 3D Kidneys, Livers and Hearts

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New Development in Cell Therapy: Veto Cell Technology

Overcoming graft rejection is the main obstacle when it comes to stem cell regeneration or organ transplantation. Scientists are investigating whether Veto Cell technology, which selectively tunes immune response, can change how immunologists treat blood cancers and bone marrow transplants, as well as the process of how organs are repaired and new ones are regenerated. Itamar Shimat, Cell Source’s CEO is available to talk about his company’s recent breakthroughs with Veto Cell technology.

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Sophisticated HIV Diagnostics Adapted for Remote Areas

Diagnosing HIV and other infectious diseases presents unique challenges in remote locations that lack electric power, refrigeration, and appropriately trained health care staff. To address these issues, researchers funded by the National Institutes of Health (NIH) have developed a low-cost, electricity-free device capable of detecting the DNA of infectious pathogens, including HIV-1.

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Tropical Inspiration for an Icy Problem

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Ice poses major impediments to winter travel, accumulating on car windshields and airplane wings and causing countless unsuspecting pedestrians to dramatically lose their balance. A team of researchers from Arizona State University (ASU) has developed a new way to prevent ice buildup on surfaces like airplane wings, finding inspiration in an unusual source: the poison dart frog.

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Chemical Disguise Transforms RNAi Drug Delivery

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Researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells. Once inside, cellular machinery converts these disguised drug precursors — called siRNNs — into active RNAi drugs.

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Regenerative Medicine Could Hold Next Steps in Treating Foot and Leg Ulcers

New and more effective treatments for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) are sorely needed. One of the today’s most promising approaches harnesses regenerative medicine, specifically cell therapy. Israel-based Macrocure Ltd.’s lead product, CureXcell™, harnesses living white blood cells, including macrophages, neutrophils and lymphocytes, that are crucial to initiating, promoting and completing the process of cellular regeneration and wound healing for both of these conditions.

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Synthetic Lethality Offers a New Approach to Kill Tumor Cells

The scientific community has made significant strides in recent years in identifying important genetic contributors to malignancy and developing therapeutic agents that target altered genes and proteins. A recent approach to treat cancer called synthetic lethality takes advantage of genetic alterations in cancer cells that make them more susceptible to certain drugs. Alan F. List, MD, president and CEO of Moffitt Cancer Center, co-authored an article on synthetic lethality featured in the October 30 issue of the New England Journal of Medicine.

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GW Researcher Adapting Breakthrough Technologies to Combat Parasitic Worm Infections

Paul Brindley, Ph.D., professor of microbiology, immunology, and tropical medicine, and scientific director of the Research Center for Neglected Diseases of Poverty at the George Washington University School of Medicine and Health Sciences, co-authored a perspective in the journal Science, calling for researchers to adapt new technologies to research neglected parasitic flatworms.

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New Compounds Reduce Debilitating Inflammation

Six Case Western Reserve scientists are part of an international team that has discovered two compounds that show promise in decreasing inflammation in diseases such as ulcerative colitis and arthritis. The compounds appear to curtail inflammation-triggering signals from RIPK2. These findings appear in the Journal of Biological Chemistry.

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First Step: From Human Cells to Tissue-Engineered Esophagus

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In a first step toward future human therapies, researchers at The Saban Research Institute of Children’s Hospital Los Angeles have shown that esophageal tissue can be grown in vivo from both human and mouse cells.

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