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Computational Tool Translates Complex Data into Simplified 2-Dimensional Images
Researchers at Columbia University and Stanford University have developed a computational method that enables scientists to visualize and interpret “high-dimensional” data produced by single-cell measurement technologies such as mass cytometry. The method, published today in the online edition of Nature Biotechnology, has particular relevance to cancer research and therapeutics. |
Embargo expired: 5/19/2013 1:00 PM EDT
Released: 5/16/2013 7:00 PM EDT
Columbia University Medical Center |
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Research On Cilia Heats Up: Implications For Hearing, Vision Loss And Kidney Disease
Experiments at Johns Hopkins have unearthed clues about which protein signaling molecules are allowed into hollow, hair-like “antennae,” called cilia, that alert cells to critical changes in their environments. |
Embargo expired: 5/12/2013 1:00 PM EDT
Released: 5/9/2013 3:00 PM EDT
Johns Hopkins Medicine |
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Immune Cells That Suppress Genital Herpes Infections IdentifiedFred Hutchinson Cancer Research Center and University of Washington scientists have identified a class of immune cells that reside long-term in the genital skin and mucosa and are believed to be responsible for suppressing recurring outbreaks of genital herpes. These immune cells also play a role in suppressing symptoms of genital herpes, which is why most sufferers of the disease are asymptomatic when viral reactivations occur. The discovery of this subtype of immune cells, called CD8αα+ T cells, opens a new avenue of research to develop a vaccine to prevent and treat herpes simplex virus type 2, or HSV-2. Identifying these T cells’ specific molecular targets, called epitopes, is the next step in developing a vaccine. |
Embargo expired: 5/8/2013 1:00 PM EDT
Released: 5/3/2013 12:50 PM EDT
Fred Hutchinson Cancer Research Center |
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Progerin’s “Discrimination” May Contribute to Fatal Disease HGPS
A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus, according to a study in The Journal of Cell Biology. |
Embargo expired: 5/6/2013 12:00 PM EDT
Released: 5/3/2013 12:00 PM EDT
Rockefeller University Press |
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New Device Can Extract Human DNA with Full Genetic Data in MinutesUniversity of Washington engineers and NanoFacture, a Bellevue, Wash., company, have created a device that can extract human DNA from fluid samples in a simpler, more efficient and environmentally friendly way than conventional methods. |
Released: 5/6/2013 11:00 AM EDT
University of Washington |
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Wip1 Could Be New Target for Cancer Treatment
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers. |
Embargo expired: 5/6/2013 12:00 AM EDT
Released: 5/3/2013 12:00 PM EDT
Rockefeller University Press |
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Researchers Join Forces to Stop Invasive Plants
University of Alabama in Huntsville assistant biology professor Dr. Leland Cseke and HudsonAlpha Institute for Biotechnology researcher Dr. Jian Han have joined forces to identify invasive plant species that are sneaking into the US. |
Released: 4/29/2013 9:50 AM EDT
University of Alabama Huntsville |
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Genetic Analysis Tool Opens New Gene-Regulation RealmsResearchers from Huntsman Cancer Institute (HCI) at the University of Utah have developed a novel and powerful technique to identify the targets for a group of enzymes called RNA cytosine methyltransferases (RMTs) in human RNA. |
Released: 4/22/2013 11:00 AM EDT
University of Utah Health Sciences |
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Stem Cell Transplant Restores Memory, Learning in MiceFor the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember. |
Embargo expired: 4/21/2013 1:00 PM EDT
Released: 4/17/2013 12:00 PM EDT
University of Wisconsin-Madison |
MedicineChannels:Keywords:Cancer, cancer metabolism, Gene Expression, metabolic expression, Drug Target, Tumor, metabolic alterations , Cell Metabolism, Glucose, Otto Warburg, nucleotide biosynthesis , glycolysis , cancer mutation, tumor formation, isocitrate dehydrogenase, Glioblastoma, Acute Myeloid Leukemia, Metabolite, 2-hydroxyglutarate, Tumor Growth, isocitrate dehydrogenase exp |
Hundreds of Potential Drug Targets to Starve Tumors Identified
A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer, as well as hundreds of potential drug targets that could cut off a tumor’s fuel supply or interfere with its ability to synthesize essential building blocks. Published in Nature Biotechnology. |
Embargo expired: 4/21/2013 1:00 PM EDT
Released: 4/17/2013 5:40 PM EDT
Columbia University Medical Center |