Wake Forest Scientists Find Way To Short-Circuit Initial HIV Invasion
Atrium Health Wake Forest BaptistScientists at Wake Forest University Baptist Medical Center report today that they have found another way to shut down the doorway for HIV-1 to invade two types of white blood cells -- lymphocytes and macrophages. In a report in the Oct 14 issue of the Proceedings of the National Academy of Sciences, Si.-Yi Chen, M.D., Ph.D., assistant professor of cancer biology, and his colleagues describe how they have inactivated the most frequently used co-receptor -- docking site -- for HIV-1 viruses on the surface of both macrophages and lymphocytes, resulting in immunity of those macrophages and lymphocytes to HIV-1 infection.