How a protein component of nuclear pore complexes regulates development of blood cells and may contribute to myeloid disorders
Sanford Burnham PrebysNuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cell survival, proliferation, and differentiation. Recent studies suggest NPCs in cancer cells are different. Newly published research by Sanford Burnham Prebys scientists identifies a key NPC protein in the development of myeloid cells, blood cells that if not formed or working properly leads to myeloid disorders such as leukemias.