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Measuring Hidden HIV

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A new mathematical modeling technique reveals HIV virus may be replicating in body even when undetectable in the blood.

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Competing Antibodies May Have Limited the Protection Achieved in HIV Vaccine Trial in Thailand

Continuing analysis of an HIV vaccine trial undertaken in Thailand is yielding additional information about how immune responses were triggered and why the vaccine did not protect more people.

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IU Expert: New HIV Testing Guidelines Helpful, but Access to Screenings Still an Issue

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Indiana U. health policy expert Beth Meyerson said the new USPSTF screening guidelines represent an important shift in HIV testing and will result in more HIV screenings, but availability of the tests remains a big unknown.

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First Large-Scale Study to Compare Treatments for HIV-Infected Children Finds Less-Used Regimen is More Effective for Children in Low-Resource Settings

Researchers from The Children's Hospital of Philadelphia and Penn Medicine find better outcomes for efavirenz over nevirapine in children over age 3.

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Antiretroviral Regimen Associated With Less Virological Failure Among HIV-Infected Children

Elizabeth D. Lowenthal, M.D., M.S.C.E., of the University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, and colleagues conducted a study to determine whether there was a difference in time to virological failure between HIV-infected children initiating nevirapine vs. efavirenz-based antiretroviral treatment in Botswana.

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Highly Active Antiretroviral Therapies May Be Cardioprotective in HIV-Infected Children, Teens

Long-term use of highly active antiretroviral therapies (HAART) does not appear to be associated with impaired heart function in children and adolescents in a study that sought to determine the cardiac effects of prolonged exposure to HAART on children infected with the human immunodeficiency virus (HIV), according to a report published Online First by JAMA Pediatrics, a JAMA Network publication.

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Discovery May Help Prevent HIV "Reservoirs" From Forming

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how the protein that blocks HIV-1 from multiplying in white blood cells is regulated. HIV-1 is the virus that causes AIDS, and the discovery could lead to novel approaches for addressing HIV-1 “in hiding” – namely eliminating reservoirs of HIV-1 that persist in patients undergoing antiretroviral therapy. The study was published today in the online edition of the journal Cell Host & Microbe.

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Women with HIV Shown to Have Elevated Resting Energy Expenditure

Studies have shown that about 10 percent of men infected with human immunodeficiency virus (HIV) have an elevated resting energy expenditure (REE). Their bodies use more kilocalories for basic functions including circulation, body temperature, and breathing. Most studies have been conducted in men and those with solely women have had small sample sizes. A team of researchers has sought to rectify this with a matched, prospective, cross-sectional study. The results are featured in a new report published by the Journal of the Academy of Nutrition and Dietetics.

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Study Suggests New Approach to AIDS, Hepatitis

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Scientists at The Scripps Research Institute have made a counterintuitive finding that may lead to new ways to clear persistent infection that is the hallmark of such diseases as AIDS, hepatitis B and hepatitis C.

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Study Suggests Potential Therapy for HIV

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UCLA scientists have shown that temporarily blocking a protein critical to immune response actually helps the body clear itself of chronic infection. The finding suggests new approaches to treating HIV and other persistent viral infections.

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