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Medicine

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Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering, Breast Cancer, Epigenetic, Epigenetics, José Baselga, Pik3 Ca, PI3K, PI3K inhibitors , ER+, ER+ breast cancer, Science, Research

MSK Researchers Identify First Evidence of Epigenetic Role in Breast Cancer

Researchers from Memorial Sloan Kettering Cancer Center (MSK) have identified, for the first time, an epigenetic mechanism promoting breast cancer. The team found that inhibition of the PI3K pathway leads to activation of ER-dependent transcription through the epigenetic regulator KMT2D. These findings provide a rationale for epigenetic therapy in patients with PIK3CA-mutant, ER-positive breast cancer. While epigenetic factors have been known to play an important role in various cancers such as leukemia and lymphoma, this is the first evidence found in breast cancer.

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Marine Protected Areas, Swarms of Midges, Ant Hills, Coral Bleaching, and More in the Wildlife News Source

The latest research and features on ecology and wildlife.

Medicine

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Kimmel Cancer Center, Cristian Tomasetti, Bert Vogelstein, Cancer, DNA, mutatuons

New Study Finds That Most Cancer Mutations are Due to Random DNA Copying ‘Mistakes’

Johns Hopkins Kimmel Cancer Center scientists report data from a new study providing evidence that random, unpredictable DNA copying “mistakes” account for nearly two-thirds of the mutations that cause cancer. Their research is grounded on a novel mathematical model based on DNA sequencing and epidemiologic data from around the world.

Medicine

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DNA, Dna Repair, Cellular Aging, Mysteries of Aging, Dna Damage, Molecule NAD, Repairing DNA, Cell Ageing, Harvard Medical School Scientists, NAD, NMN, Sirt1, PARP1, DBC1, Genetics, protein binding, David Sinclair

Harvard Medical School Scientists Pinpoint Critical Step in DNA Repair, Cellular Aging

The body’s ability to repair DNA damage declines with age, which causes gradual cell demise, overall bodily degeneration and greater susceptibility to cancer.

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Biology, Regenerative Medicine, regenerative biology

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 30-Mar-2017 6:00 AM EDT

Medicine

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Seth Margolis, Alzheimer’s, ephexin5 , Brain, Amyloid

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 27-Mar-2017 4:00 PM EDT

Science

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Alzheimber's Disease, Neurochemistry

Researchers Focus on Cell Membranes to Develop Alzheimer's Treatments

Thin parts of the cell membranes of neurons turn out to be particularly vulnerable to a protein that collects in the brain of people with Alzheimer's disease, according to a University of Michigan researcher.

Medicine

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Cystic Fibrosis, Mucus

The Mechanism of Mucus: Discovery Could Lead to Better Cystic Fibrosis Treatments

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University of North Carolina scientists found that mucin proteins, which make mucus thick and sticky, fail to unfold properly in the airways of people with cystic fibrosis. And they found the lack of water in the lung can trigger the misfolding mucins.

Medicine

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multiple sclerosis, Neurodegenative Disease, Neurodegeneration, Research, Experimental Treatment, Cincinnati Children's Hospital Medical Center, Developmental Cell, Children, National Multiple Sclerosis Society, National Institutes For Health

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 27-Mar-2017 12:00 PM EDT

Medicine

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Zinc in the Retina May Indicate A New Way to Protect and Regenerate the Optic Nerve in Glaucoma Patients

Connecting pieces of information by finding a common thread often takes glaucoma researchers in unexpected directions. Zinc is one such thread that joined together different experts at Boston Children’s Hospital and Harvard Medical School.







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