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Released: 7-Oct-2022 12:00 PM EDT
Iron Chelation Improves Ineffective Erythropoiesis and Iron Overload in Myelodysplastic Syndrome Mice
Preprints

Wenbin An, Maria Feola, Srinivas Aluri, Marc Ruiz-Martinez, Ashwin Sridharan, Maayan Levy, Eitan Fibach, Xiaofan Zhu, Amit K Verma, Yelena Ginzburg

Released: 7-Oct-2022 12:00 PM EDT
Engineering human spinal microphysiological systems to model opioid-induced tolerance
Preprints

Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Connor Kaurich, Zi Chen, Mingxia Gu, Andrea G. Hohmann, Ken Mackie, Feng Guo

Released: 7-Oct-2022 12:00 PM EDT
Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo
Preprints

Dennis May, Sangwon Yun, David Gonzalez, Sangbum Park, Yanbo Chen, Elizabeth Lathrop, Biao Cai, Tianchi Xin, Hong-Yu Zhao, Siyuan Wang, Lauren E Gonzalez, Katie Cockburn, Valentina Greco

Released: 7-Oct-2022 12:00 PM EDT
Candidate stem cell isolation and transplantation in Hexacorallia
Preprints

Benyamin Rosental, Shani Talice, Shany Barkan, Grace Snyder, Aner Ottolenghi, Shir Eliachar, Ronit Ben-Romano, Shelly Oisher, Ton Sharoni, Magda Lewandowska, Eliya Sultan, Oron Goldstein, Reuven Aharoni, Uzi Hadad,

Released: 7-Oct-2022 12:00 PM EDT
Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
Preprints

Denise Ragusa, Chun Wai Suen, Gabriel Torregrosa Cortes, Liza Dijkhuis, Connor Byrne, Giulia-Andreea Ionescu, Joana Cerveira, Kamil R Kranc, Anna Bigas, Jordi Garcia-Ojalvo, Alfonso Martinez Arias, Cristina Pina

Newswise: New Center for Experimental Therapeutics in Cancer advances promising treatments
Released: 7-Oct-2022 6:05 AM EDT
New Center for Experimental Therapeutics in Cancer advances promising treatments
UC Davis Health

UC Davis Comprehensive Cancer Center has launched a Center for Experimental Therapeutics in Cancer to accelerate promising cancer therapies from the lab to the bedside. The idea is to advance precision medicine that leads to more effective, less toxic cancer therapies.

Released: 6-Oct-2022 12:00 PM EDT
The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
Preprints

Luke D Roberts, Amanda K. E. Hornsby, Alanna Thomas, Martina Sassi, Aimee Kinzett, Nathan Hsiao, Bethan R David, Mark Good, Timothy Wells, Jeffrey S Davies

Released: 6-Oct-2022 12:00 PM EDT
PEDF peptide stimulates chondrocyte regeneration in rats with monoiodoacetate-induced articular cartilage injury
Preprints

Yung-Chang Lu, Tsung-Chuan Ho, Chang-Hung Huang, Shu-I Yeh, Show-Li Chen, Yeou-Ping Tsao

Released: 6-Oct-2022 12:00 PM EDT
Muscle hypertrophy and neuroplasticity in the small bowel in Short Bowel Syndrome
Preprints

Rasul Khasanov, Daniel Svoboda, María Ángeles Tapia-Laliena, Martina Kohl, Silke Maas-Omlor, Cornelia Irene Hagl, Lucas M. Wessel, Karl-Herbert Schäfer

Released: 6-Oct-2022 12:00 PM EDT
Enhanced clinical assessment of hematologic malignancies through routine paired tumor:normal sequencing
Preprints

Ryan N. Ptashkin, Mark D. Ewalt, Gowtham Jayakumaran, Iwona Kiecka, Anita S. Bowman, Jinjuan Yao, Jacklyn Casanova, Yun-Te David Lin, Kseniya Petrova-Drus, Abhinita S. Mohanty, Ruben Bacares, Jamal Benhamida, Satshil Rana, Anna Razum

Released: 6-Oct-2022 12:00 PM EDT
Long-term survivors demonstrate superior quality of life after haploidentical stem cell transplantation to matched sibling donor transplantation
Preprints

Xiaoyu Zhang, Jiao Wang, Yuqiu Liu, Jie Liu, Bei Wang, Qiuhui Zhang, Wei Guan, Huijuan Zhang, Li Xu, Guiying Liu, Ping Zhang, Yi He, Sizhou Feng, Mingzhe Han, Changping Li,

Released: 6-Oct-2022 12:00 PM EDT
Emergency hematopoiesis proceeds without contribution of hematopoietic stem cells
Preprints

Clara Marie Munz, Nicole Dressel, Minyi Chen, Tatyana Grinenko, Axel Roers, Alexander Gerbaulet

Released: 6-Oct-2022 12:00 PM EDT
Distinct modes of heat shock transcription factor interactions with mitotic chromosomes
Preprints

Rachel M Price, Marek A Budzyński, Junzhou Shen, Jennifer E. Mitchell, James Z.J. Kwan, Sheila S. Teves

Released: 6-Oct-2022 12:00 PM EDT
Prediction of diabetes mellitus development after kidney transplantation using patient-specific induced pluripotent stem cells
Preprints

Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang

Released: 6-Oct-2022 12:00 PM EDT
α-synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased uptake into neurons
Preprints

Amberley D Stephens, Ana Fernandez-Villegas, Chyi Wei Chung, Oliver Vanderpoorten, Dorothea Pinotsi, Ioanna Mela, Edward Nicholas Ward, Thomas M McCoy, Robert Cubitt, Alexander F Routh, Clemens F Kaminski, Gabriele S Kaminski Schierle

Released: 6-Oct-2022 9:30 AM EDT
DOE Funds Pilot Study Focused on Biosecurity for Bioenergy Crops
Brookhaven National Laboratory

The U.S. Department of Energy’s (DOE) Office of Science has selected Brookhaven National Laboratory to lead a new research effort focused on potential threats to crops grown for bioenergy production. Understanding how such bioenergy crops could be harmed by known or new pests or pathogens could help speed the development of rapid responses to mitigate damage and longer-term strategies for preventing such harm.

Released: 6-Oct-2022 5:00 AM EDT
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes
Cell Stem Cell

By characterizing the epigenome of direct reprogramming processes, Qian and colleagues discovered common features of direct reprogramming. Particularly, Ascl1, the neuron reprogramming factor, activates a unique set of cardiac genes. Together with As

Released: 6-Oct-2022 5:00 AM EDT
Pervasive donor DNA integration defies precision gene editing of hematopoietic stem cells
Cell Stem Cell

Therapeutic gene editing based on homology-directed repair (HDR) promises to precisely recombine donor template sequences at programmed double-strand break sites. In this issue, Ferrari et al. report that commonly used AAV donors blunt hematopoietic

Released: 6-Oct-2022 5:00 AM EDT
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures
Cell Stem Cell

Three recent studies from the Zernicka-Goetz and Hanna groups (Amadei et al., 2022; Tarazi et al., 2022; Lau et al., 2022) report the development of mouse embryo-like structures from stem cells. Using a combination of stem cell-derived sources, th

Released: 6-Oct-2022 5:00 AM EDT
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination
Cell Stem Cell

Fibrosis, the pathological end stage of chronic inflammatory diseases, results from extracellular matrix deposition by fibrogenic fibroblasts. In this issue of Cell Stem Cell, Sobecki et al. (2022) develop a novel vaccination-based immunotherapy aga

Released: 5-Oct-2022 12:00 PM EDT
Inflammation drives age-induced loss of tissue resident macrophages
Preprints

Kémy Adé, Javier Saenz Coronilla, Dorian Obino, Tobias Weinberger, Caroline Kaiser, Sebastien Mella, Cheng Chen, Lida Katsimpardi, Catherine Werts, Pascal Dardenne, Yvan Lallemand, Elisa Gomez-Perdiguero

Released: 5-Oct-2022 12:00 PM EDT
Loss of the MLL3 tumor suppressor accelerates breast tumor onset via HIF1a-induced CCL2-mediated recruitment of CCR2+ regulatory T cells
Preprints

Marie Boutet, Piril Erler, Kenta Nishitani, Nicole Couturier, Zheng Zhang, Emeline Barbieux, Erik Guillen, Masako Suzuki, Gregoire Lauvau, Wenjun Guo

Released: 5-Oct-2022 12:00 PM EDT
Chemical Imaging Reveals Diverse Functions of Tricarboxylic Acid Metabolites in Root Growth and Development
Preprints

Tao Zhang, Sarah E. Noll, Jesus T. Peng, Amman Klair, Abigail Tripka, Nathan Stutzman, Casey Cheng, Richard N Zare, Alexandra Jazz Dickinson

Released: 5-Oct-2022 12:00 PM EDT
A corset of adhesions during development establishes individual neural stem cell niches and controls adult behaviour
Preprints

Agata Banach-Latapy, Vincent Rincheval, David Briand, Isabelle Guenal, Pauline Speder

Released: 5-Oct-2022 12:00 PM EDT
Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation
Preprints

Chuanying Geng, Huixing Zhou, Huijuan Wang, Yanchen Li, Yun Leng, Zhiyao Zhang, Yuan Jian, Guangzhong Yang, Wenming Chen

Released: 5-Oct-2022 12:00 PM EDT
Human induced pluripotent stem cell culture v1
Preprints

Gurvir.Virdi Not Provided

Released: 5-Oct-2022 12:00 PM EDT
Neuron-derived exosomes trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease
Preprints

Zhichun Chen, Chongchong Xu, Guanglu Li, Zhexing Wen, Jun Liu, Zixu Mao

Released: 5-Oct-2022 5:05 AM EDT
Bright genetics: directed mutations increased the stability of proteins-lights
Scientific Project Lomonosov

Russian scientists acquired stable and bright fluorescent protein moxSAASoti, which can change color and intensity of its fluorescence. To achieve this aim, the scientists made point changes in the sequence of the coding gene.

Newswise: Tissue chip developments: what’s the 411?
Released: 4-Oct-2022 2:05 PM EDT
Tissue chip developments: what’s the 411?
National Institute of Biomedical Imaging and Bioengineering

NIBIB-funded researchers have developed an interlinked tissue chip system that can model four mature organs in their perspective environments simultaneously. These multi-organ tissue chips could represent a new way to evaluate diseases or drugs that affect multiple different tissues.

Released: 4-Oct-2022 12:00 PM EDT
Single cell transcriptomics of human prenatal anterior foregut-derived organs identifies distinct developmental signatures directing commitment and specialization of the thymic epithelial stroma
Preprints

Abdulvasey Mohammed, Priscila Ferreira Slepicka, Benjamin Solomon, Kelsea M Hubka, Michael G Chavez, Christine Y Yeh, Virginia D Winn, Casey A Gifford, Purvesh Khatri, Andrew Gentles, Katja Gabrielle Weinacht

Released: 4-Oct-2022 12:00 PM EDT
In vivo generation of heart and vascular system by blastocyst complementation
Preprints

Giulia Coppiello, Paula Barlabe, Marta Moya-Jodar, Gloria Abizanda, Carolina Barreda, Elena Iglesias, Javier Linares, Estibaliz Arellano-Viera, Adrian Ruiz-Villalba, Eduardo Larequi, Xonia Carvajal-Vergara, Beatriz Pelacho, Felipe Prosper, Xabier L. Arangur

Released: 4-Oct-2022 12:00 PM EDT
Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2.
Preprints

Paolo Petazzi, Telma Ventura, Alisha May, Francesca Paola Luongo, Helen Alice Taylor, Nicola Romanò, Lesley Margaret Forrester, Pablo Menéndez, Antonella Fidanza

Released: 3-Oct-2022 12:00 PM EDT
Establishment of a human pluripotent stem cell-derived MKX-tdTomato reporter system
Preprints

Yuki Fujisawa, Ming Lu, Daisuke Yamada, Tomoka Takao, Takeshi Takarada

Released: 3-Oct-2022 12:00 PM EDT
Integrative Cut&Tag/RNA-Seq analysis of histone variant macroH2A1-dependent orchestration of human iPSCs reprogramming
Preprints

Niccolo Liorni, Alessandro Napoli, Stefano Castellana, Sebastiano Giallongo, Daniela Rehakova, Oriana Lo Re, Irena Koutna, Tommaso Mazza, Manlio Vinciguerra

Newswise: ABRF 2023 Research Group Studies
Released: 3-Oct-2022 11:05 AM EDT
ABRF 2023 Research Group Studies
Association of Biomolecular Resource Facilities (ABRF)

The Association of Biomolecular Resource Facilities (ABRF) Executive Board is pleased to announce the approval of several innovative studies to be conducted by ABRF Research Groups in 2023, to address ongoing questions in biomolecular research techniques and methods.

Newswise: US has capacity to make essential drugs, study finds
Released: 3-Oct-2022 11:05 AM EDT
US has capacity to make essential drugs, study finds
Washington University in St. Louis

The White House has sounded the alarm about vulnerabilities in the pharmaceutical supply chain. But new research from the Center for Analytics and Business Insights at Olin Business School found that the U.S. actually has the capacity to make the nation’s most essential and critical drugs — yet it's mostly sitting idle.

Released: 2-Oct-2022 12:00 PM EDT
Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrients
Preprints

Heather A McCauley, Anne Marie Riedman, Jacob R Enriquez, Xinghao Zhang, Miki Watanabe-Chailland, J. Guillermo Sanchez, Daniel O. Kechele, Emily F. Paul, Kayle Riley, Courtney Burger, Richard A Lang, James M. Wells

Released: 1-Oct-2022 12:00 PM EDT
Dual states of Bmi1-expressing intestinal stem cells drive epithelial development and tissue regeneration
Preprints

Nicholas R. Smith, Sidharth K. Sengupta, Patrick Conley, Nicole R. Giske, Christopher Klocke, Brett S. Walker, Noelle McPhail, John R. Swain, Yeon Jung Yoo, Ashley N. Anderson, Paige S. Davies, Nasim Sanati, Theresa N. Nguyen, Kristo

Released: 1-Oct-2022 12:00 PM EDT
Temporal Extracellular Vesicle Protein Changes following Intraarticular Treatment with Integrin α10β1-selected Mesenchymal Stem Cells in Equine Osteoarthritis
Preprints

Emily J Clarke, Emily Johnson, Eva Caamano Gutierrez, Camilla Andersen, Lise Berg, Rosalind Jenkins, Casper Lindegaard, Kristina Uvebrant, Evy Lundgren-Akerlund, Agnieszka Turlo, Victoria James, Stine Jacobsen, Mandy J. Peffers



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