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Targeting Melanoma, Lymphoma: Study Finds Investigational Compound Active Against Cancer Driven by Genetic Mutation

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Compound found to be highly active against cancer driven by EZH2 mutation in laboratory models

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Stem Cell Study Finds Mechanism That Controls Skin and Hair Color

A pair of molecular signals controls skin and hair color in mice and humans — and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.

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Survey: Men’s Skin Cancer Knowledge Lags Behind Women’s

Skin cancer can affect anyone, regardless of age, race or gender. When it comes to skin cancer prevention and detection, however, it seems that men need to brush up on their knowledge.

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All Hairstyles Are Not Created Equal

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In a review of 19 studies, researchers at Johns Hopkins say they can confirm a “strong association” between certain scalp-pulling hairstyles — many common among African-Americans — and the development of traction alopecia, gradual hair loss caused by damage to the hair follicle from prolonged or repeated tension on the hair root.

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Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source

Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source

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Penn Medicine Study Uncovers New Pathways That Control Skin Tanning and Lightening

When skin cells responsible for pigmentation are exposed to estrogen or progesterone, the cells respond by adjusting their melanin production, resulting in either skin darkening or lightening. Although pregnant women often experience alterations in skin pigmentation, the reason for the changes has long puzzled physicians. New research, from the Perelman School of Medicine at the University of Pennsylvania, has uncovered cellular pathways in skin pigment cells that are activated by estrogen and progesterone – two of the main female sex hormones - and also identified synthetic hormone derivatives that specifically influence the pigment producing pathway. Together, the findings provide critical information that could lead to the development of new products that change skin tone without exposure to UV radiation or toxic bleaching agents.

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Medicare Patients Have Low Adherence to Biologic Drug Therapy for Psoriasis

About half of Medicare patients who start taking biologic therapies for moderate to severe plaque psoriasis stop within a year, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania. Previous studies have found similar results among the privately insured in the United States. The new study is the first to explore this issue among the elderly and disabled who are covered under Medicare. Lack of data in this population has been a major research gap, given that such patients are often underrepresented in clinical trials.

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Penn Study Suggests Changes in Skin “Microbiome” During Canine Atopic Dermatitis Could Lead to Antibiotic-Free Therapies for Human and Canine Disease

Atopic dermatitis (AD), a chronic inflammatory skin condition and the most common form of eczema, is estimated to afflict as much as 10 percent of the U.S. population, and is much more common now than it was 50 years ago. Veterinary clinical estimates also show that approximately 10 percent of dogs have atopic dermatitis. How AD arises isn’t yet fully understood, but a new study from researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn’s School of Veterinary Medicine, have uncovered important insights about the association of AD in dogs compared to humans. The study appears online in the Journal of Investigative Dermatology.

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Vitamins May Protect Against Nerve Damage in Breast Cancer Treatment, and more Cancer News in the Newswise Channels

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The Role of Family and the Media in Childhood Obesity, and more Children's Health News in the Newswise Channels

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Strength Train to Live Longer, and more news on Aging-related topics in the Newswise Channels

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Immunotherapy Drug Shrinks Tumors in Half of Patients with Rare, Virus-Linked Skin Cancer

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In a clinical trial of the immunotherapy drug pembrolizumab, half of 25 patients with a rare type of virus-linked skin cancer called Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long, on average, than with conventional chemotherapy.

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Longest Follow-Up of Survival After Treatment with Nivolumab Reported at AACR Annual Meeting 2016

A team of researchers led by Ludwig Cancer Research scientist Stephen Hodi reported today the results of the longest follow-up survival study conducted to date on patients with advanced melanoma who were treated with the PD-1 inhibitor nivolumab. Hodi and his colleagues announced at a press event during the American Association for Cancer Research Annual Meeting in New Orleans that 34 percent of the patients treated with this immunotherapy alone in a previous Phase 1 trial were still alive five years later.

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American Academy of Dermatology Annual Meeting Draws More Than 18,500 to D.C.

More than 18,500 people from 107 countries attended the American Academy of Dermatology’s 74th Annual Meeting, which ran from March 4-8 at the Walter E. Washington Convention Center in Washington.

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Suzanne Olbricht, MD, FAAD, to Be Next President-Elect of the American Academy of Dermatology

Board-certified dermatologist Suzanne Olbricht, MD, FAAD, is named president-elect of the American Academy of Dermatology (Academy), the world’s largest dermatologic society, which represents more than 18,000 physicians who specialize in the diagnosis and treatment of skin, hair and nail conditions.

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American Academy of Dermatology Announces New Officers and Board Members

The American Academy of Dermatology (Academy) has announced the results of its annual election.

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Dermatologists Share Tips for Treating Corns and Calluses

Ever wonder what causes corns and calluses? According to dermatologists from the American Academy of Dermatology, these hard, thickened areas of skin form as a result of friction or pressure on the skin. In fact, they say, corns and calluses develop naturally to help protect the skin underneath them.

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Macrophages Surrounding Lymph Nodes Block the Progression of Melanoma, Other Cancers

Researchers at Massachusetts General Hospital (MGH) have identified a type of immune cell that appears to block the progress of melanoma and other cancers in animal models. These subcapsular sinus (SCS) macrophages form a protective coating around lymph nodes, preventing the entry of tiny structures that transport bits of tumor tissue and help the cancer to grow and spread. However, the SCS macrophage barrier appears to be temporary, as it breaks down as the tumor progresses and in response to some cancer treatment drugs.

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Aging Impacts Therapeutic Response of Melanoma Cells

An international team of scientists led by The Wistar Institute have shown that aged tumor cells in melanoma behave differently than younger tumor cells, according to study results published in the journal Nature. Changes in the microenvironment make these older tumor cells more metastatic and more resistant to treatment with targeted therapies.

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Why Do Sunbathers Live Longer Than Those Who Avoid the Sun?

New research looks into the paradox that women who sunbathe are likely to live longer than those who avoid the sun, even though sunbathers are at an increased risk of developing skin cancer.