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Medicine

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Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering, Breast Cancer, Epigenetic, Epigenetics, José Baselga, Pik3 Ca, PI3K, PI3K inhibitors , ER+, ER+ breast cancer, Science, Research

MSK Researchers Identify First Evidence of Epigenetic Role in Breast Cancer

Researchers from Memorial Sloan Kettering Cancer Center (MSK) have identified, for the first time, an epigenetic mechanism promoting breast cancer. The team found that inhibition of the PI3K pathway leads to activation of ER-dependent transcription through the epigenetic regulator KMT2D. These findings provide a rationale for epigenetic therapy in patients with PIK3CA-mutant, ER-positive breast cancer. While epigenetic factors have been known to play an important role in various cancers such as leukemia and lymphoma, this is the first evidence found in breast cancer.

Medicine

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Oral Health, oral health research, Maxillofacial, Maxillofacial Surgery, Dental School, Dental Research, dental medicine

Columbia U. Dental School Dean Honored for Service to Oral Health Research

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The American Association of Dental Research presented the Jack Hein Public Service Award to Dean Christian S. Stohler of the Columbia University College of Dental Medicine

Science

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Catalysts, CO2, Methanol, Chemistry

Chemists ID Catalytic 'Key' for Converting CO2 to Methanol

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Results from experiments and computational modeling studies that definitively identify the "active site" of a catalyst commonly used for making methanol from CO2 will guide the design of improved catalysts for transforming this pollutant to useful chemicals.

Medicine

Life

Social and Behavioral Sciences

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Mental Illness, Mental Health, Psycholgoy, Depression, DSM-5, Mental Disorder, Major depressive disorder (MDD)

Research Consortium Develops Evidence-Based Diagnostic Model for Mental Illness

Researchers have developed a new, evidence-based alternative to the mental health field’s long-established diagnostic tools for the classification, treatment, and research of mental disorders. The Hierarchical Taxonomy of Psychopathology (HiTOP) addresses what the authors say are limitations to the reliability and validity of traditional models.

Medicine

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Periodontal, Periodontal Disease, Research, Award Announcement, Dental Research, dental researcher

Columbia U. Scientist Receives International Award for Periodontal Disease Research

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Dr. Panos Papapanou received the IADR Distinguished Scientist Award in Basic Research in Periodontal Disease for research on the epidemiology of periodontal diseases, their pathobiology, assessment of microbial and host-derived risk factors, as well as the diseases’ role as health stressor in heart disease and pregnancy complications.

Science

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Theoretical Physicist, Award Announcement

Brookhaven Lab's Bjoern Schenke Receives Zimanyi Medal

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Bjoern Schenke, a theoretical physicist at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, has been awarded the 2017 Zimanyi Medal in Nuclear Theory.

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Discovery of New Ginger Species Spices Up African Wildlife Surveys

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Scientists from WCS have discovered a new species of wild ginger, spicing up a wave of recent wildlife discoveries in the Kabobo Massif – a rugged, mountainous region in Democratic Republic of Congo.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 27-Mar-2017 11:00 AM EDT

Business

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Sears, Bankrupt, Consumerism, sonsumer culture, american capitalism, Capitalism

Demise of Sears Tears Fabric of Consumer Culture

Science

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NSLS-II, Fungus, Plants

Investigating the Benefits of Cooperation

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Tiny strands of fungi weave through the roots of an estimated nine out of 10 plants on Earth, an underground symbiosis in which the plant gives the fungus pre-made sugars and the fungus sends the plant basic nutrients in return. Scientists are interested in enhancing this mechanism as a way to help plants grow on nutrient-poor lands.







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