Calcium bursts kill drug-resistant tumor cells
American Chemical Society (ACS)Researchers reporting in ACS’ Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR.
Researchers reporting in ACS’ Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR.
A study aimed at better understanding why some critically ill patients develop multidrug-resistant infections is underway by researchers at The University of Texas Health Science Center at Houston (UTHealth). The multi-institution study will enroll patients at Memorial Hermann Hospital-Texas Medical Center and The University of Texas MD Anderson Cancer Center.
A team led by Penn Medicine has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom. The team hopes to develop the molecules into new bacteria-killing drugs, an important advancement considering increasing numbers of antibiotic-resistant bacteria which can cause illness such as sepsis and tuberculosis.
UCLA researchers have received a $13 million grant from the National Institutes of Health to find new ways to overcome melanoma resistance to some of the most promising targeted therapies and immunotherapies.
Researchers have sequenced the genome of Alexander Fleming's penicillin mould for the first time and compared it to later versions.
The Center for Integrated Management of Antimicrobial Resistance, a collaborative effort supported by Tufts University and Tufts Medical Center, has been renamed the Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance, to honor the pioneering antibiotic-resistance researcher.
St. Jude researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process.
According to the Global Hygiene Council's (GHC) public health experts, following a risk-based approach to home hygiene is essential to help curb the growing threat of antibiotic resistance.
More than half of patients hospitalized with suspected COVID-19 in Michigan during the state’s peak months received antibiotics soon after they arrive, just in case they had a bacterial infection in addition to the virus, a new study shows. But testing soon showed that 96.5% of them only had the coronavirus, which antibiotics don’t affect.
More frequent seizures during the menstrual cycle in women with genetic generalized epilepsy have been linked for the first time to drug-resistant epilepsy, when anti-seizure medications don’t work, according to a Rutgers coauthored study that may help lead to tailored treatments. Women with a form of genetic generalized epilepsy called catamenial epilepsy – when seizure frequency increases during their menstrual cycle – were nearly four times more likely to have drug-resistant epilepsy than women who experience no changes in frequency, according to the study in the journal Neurology. This association was found in two independent samples.
The use of antibiotics in people with COVID-19 could result in increased resistance to the drugs' benefits among the wider population, a new study suggests.
The human microbiota plays an important role in health and well-being by assisting in digestion, producing nutrients, resisting invading pathogens and regulating metabolism and the immune system.
Scientists have developed an injectable drug that blocks HIV from entering cells. They say the new drug potentially offers long-lasting protection from the infection with fewer side effects.
Scientists have found clear indicators for how the interaction of poor hygiene and antibiotic use contribute to the colonization of antimicrobial-resistant (AMR) bacteria in humans, a problem that contributes to hundreds of thousands of deaths annually.
A multiple sclerosis drug may be used to block HIV infection and reduce the latent reservoir, according to research published in PLOS Pathogens by a team at the RGeorge Washington University.
Antibiotic resistance is an increasing health problem, but new research suggests it is not only caused by the overuse of antibiotics. It’s also caused by pollution.
In order to combat bacterial wound infections, Empa researchers have developed cellulose membranes equipped with antimicrobial peptides. Initial results show: The skin-friendly membranes made of plant-based materials kill bacteria very efficiently.
A specific combination of HIV and TB treatments, difficult to obtain in certain parts of the world, decreased mortality risk for patients with HIV and multidrug-resistant TB
A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it.
Scientists at Huntsman Cancer Institute at the University of Utah report today the development of new models to study molecular characteristics of tumors of the lung and pancreas that are driven by mutations in a gene named NTRK1. The findings were published today in the journal Cell Reports.
To fight antibiotic resistance more antimicrobials are needed to treat bacterial biofilms, which protect an infection from antibiotics
Research presented at ASM Microbe Online found that 43% of Staphylococcus bacteria found on exercise equipment in university gyms were ampicillin-resistant, with 73% of those isolates being resistant to multiple additional drugs. The late Xin Fan, Ph.D., and her student Chase A. Weikel of West Chester University (WCU) conducted the research in cooperation with WCU's John M. Pisciotta, Ph.D., associate professor of Biology.
Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. Suggesting phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes.
A new cell profiling technology combines high throughput imaging and machine learning to provide a rapid, cost-effective way to determine how specific compounds act to destroy the bacterium that causes tuberculosis. It could speed discovery of anti-TB drugs and be applied to other pathogens.
Researchers fear that widespread use of antibiotics during the coronavirus pandemic will add fuel to the fire, making more common infections that were once treatable possibly life threatening.
Scientists at Hokkaido University and collaborators have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance, resulting in poor prognosis of cancer patients.
Researchers at Washington University in St. Louis and the National Institutes of Health (NIH) have found that genes that confer the power to destroy tetracycline antibiotics are widespread in bacteria. But the researchers have also created a chemical compound that shields tetracyclines from destruction, restoring the antibiotics lethality. The findings indicate an emerging threat to one of the most widely used classes of antibiotics — but also a promising way to protect against that threat.
Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health (NIH) totaling more than $5 million to study two types of parasitic worm infection that cause devastating illness in millions of people worldwide. One project will focus on onchocerciasis, commonly known as river blindness. The second project will target fascioliasis, commonly found in cattle-farming operations.
Next-gen nano technologies that can prevent infection and diagnose disease are set to transform the medical industry as this important UniSA research is awarded more than $2 million dollars under the National Health and Medical Research Council (NHMRC) 2021 Investigator Grants.
Researchers found that co-administering dephostatin and colistin in mice with a lethal Salmonella infection significantly prolonged animal survival and used a lower concentration of colistin than is normally required for treatment, thereby reducing its toxic effect.
To counter drug resistance Penn State engineers have developed a new approach for predicting which mutation has expanded the most in a population and should be targeted to design the most effective new drug.
Research from the University of Sheffield and the University of Bath has discovered how a common pathogen is able to infect both cattle and humans
For a bacterial pathogen already resistant to an antibiotic, prolonged exposure to that antibiotic not only boosted its ability to retain its resistance gene, but also made the pathogen more readily pick up and maintain resistance to a second antibiotic and become a dangerous, multidrug-resistant strain.
Drug resistance is a major obstacle in cancer treatment—leading to relapse for many patients. In a new study, published online April 20, 2020, in Nature Cell Biology, researchers from the Stowers Institute for Medical Research, Children’s Mercy Kansas City, and The University of Kansas Cancer Center report on a promising new strategy to overcome drug resistance in leukemia, using targeted doses of the widely-used chemotherapy drug doxorubicin.
An analysis revealed that water samples held a cocktail of pharmaceuticals and other compounds, including antibiotics, antifungals, anticonvulsants, anesthetics, antihypertensive drugs, pesticides, flame retardants and more. Not all chemicals were found at every test site.
Researchers have been able to identify and track the exchange of genes among bacteria that allow them to become resistant to drugs, according to a new study published today in eLife.
Researchers from Washington University in St. Louis studied the gut microbiomes of wild apes in the Republic of Congo, of captive apes in zoos in the U.S., and of people from around the world and discovered that lifestyle is more important than geography or even species in determining the makeup of the gut microbiome.
Since the discovery of penicillin in 1928 by Sir Alexander Fleming, antibiotics have saved millions of lives from fatal infections world-wide. However, with time bacteria have developed mechanisms to escape the effects of antibiotics - they have become resistant.
Researchers reporting in Environmental Science & Technology have shown that when waste is burned or buried, it can be a source of antibiotic-resistance genes in the air.
Engineers have created a tiny device that can rapidly detect harmful bacteria in blood, allowing health care professionals to pinpoint the cause of potentially deadly infections and fight them with drugs. The Rutgers coauthored study, led by researchers at Rochester Institute of Technology, is published in the journal ACS Applied Materials & Interfaces.
Drug resistance is a leading cause of cancer death in children and adults with leukemia. St. Jude Children’s Research Hospital scientists have developed a novel strategy to find the genes responsible.
With drug resistance a major challenge in the fight against cancer, a discovery by University of California, Irvine biologists could offer new approaches to overcoming the obstacle. Their research reveals that a mechanism enabling the diseased cells to scavenge dead cell debris for nourishment holds a pivotal role.
Researchers at The University of Texas at El Paso and El Paso Community College discovered that the Rio Grande is a “hotspot” for multidrug-resistant bacteria, antibiotic residues and antimicrobial resistant genes.
Doctors who use drugs that target antibiotic-resistant bacteria as a first-line defense against pneumonia should probably reconsider this approach, according to a new study of more than 88,000 veterans hospitalized with the disease. The study found that pneumonia patients given these medications in the first few days after hospitalization fared no better than those receiving standard medical care for the condition.
Antibodies can be a blessing or a curse to the brain - it all depends on their concentration
Researchers investigating the drug prescription response to a “superbug” enzyme that renders bacteria resistant to antibiotics are available to discuss why such resistance is posing a growing risk during pandemics such as the current coronavirus.
A new group of antibiotics with a unique approach to attacking bacteria has been discovered, making it a promising clinical candidate in the fight against antimicrobial resistance. The newly-found corbomycin and the lesser-known complestatin have a never-before-seen way to kill bacteria, which is achieved by blocking the function of the bacterial cell wall. The discovery comes from a family of antibiotics called glycopeptides that are produced by soil bacteria.
Scientists at Berkeley Lab’s Molecular Foundry have designed a biocompatible polymer that has the potential to advance photothermal therapy, a technique that deploys near-infrared light to combat antibacterial-resistant infections and cancer.
A new study led by Washington University School of Medicine in St. Louis offers a genetic road map detailing the similarities and differences in immune responses to TB across three species — mice, macaques and humans. According to the researchers, the insight into the immune pathways that are activated in diverse models of TB infection will serve as a valuable tool for scientists studying and working to eradicate the disease.
Infectious disease scientists identified strains of group A streptococcus that are less susceptible to commonly used antibiotics, a sign that the germ causing strep throat and flesh-eating disease may be moving closer to resistance to penicillin and other related antibiotics known as beta-lactams.