New findings from the University of Kentucky published in the Journal of Neuroscience demonstrate that there may be ways to address blood-brain barrier dysfunction in epilepsy.
New research in plants shows that a gene called MUTE is required for the formation of stomata — the tiny pores that a critical for gas exchange, including releasing the oxygen gas that we breathe.
Beta peptides have become a key tool in building more robust biomaterials. These synthetic molecules mimic the structure of small proteins, but they are protected against processes that degrade natural peptides. A new study has expanded what we can do with these crafty peptides. Published in APL Bioengineering, the researchers show that molecules that have previously posed challenges to bioengineers can now be used to make new kinds of biomaterials.
Every 405,000 years, gravitational tugs from Jupiter and Venus slightly elongate Earth’s orbit, an amazingly consistent pattern that has influenced our planet’s climate for at least 215 million years and allows scientists to more precisely date geological events like the spread of dinosaurs, according to a Rutgers-led study. The findings are published online today in the Proceedings of the National Academy of Sciences.
UCLA Gram negative F. nucleatum-induced host-generated tsRNA inhibits the growth of F. nucleatum (top row) but not Streptococcus mitis (bottom row). A new UCLA-led study provides clear evidence that cellular messengers in saliva may be able to regulate the growth of oral bacteria responsible for diseases, such as periodontitis and meningitis.
For the first time, UNC School of Medicine scientists led by Nobel laureate Aziz Sancar analyzed whole-genome DNA repair in an animal over 24 hours to find which genes were repaired, where exactly, and when, laying the groundwork for a more precise use of anti-cancer drugs.
Wolters Kluwer Health announced today it has been named publisher of the Porto Biomedical Journal (PBJ) and will begin publishing the title under its Lippincott portfolio with Volume 3, Issue 1. The bimonthly open access journal publishes research conducted in the biomedical fields.
In a new study published in the April issue of the journal Terra Nova, geologists at The University of Texas at Dallas and UT Austin suggest that episodes of global cooling that geologists refer to as “Snowball Earth” can be linked to the advent of plate tectonics.
Using an informatics tool that identifies “hotspots” of post-translational modification (PTM) activity on proteins, researchers have found a previously-unknown mechanism that puts the brakes on an important cell signaling process involving the G proteins found in most living organisms.
Economic tumult in the early 2000s persuaded many young people to keep living with their parents, but the reasons why differ starkly by race, a study concludes.
Using molecular determinants combined with clinical data, UChicago physicians confirm their oligometastasis hypothesis in colorectal cancers with limited spread of disease to the liver.
Certain minuscule cancer signals easily evade detection, but perhaps no longer. Biomarkers made of glycoproteins are bound to get snared in the tentacles of this chemical octopus that Georgia Tech chemists devised over several years. The monstrous molecule could also be a windfall for the rising field of glycoscience.
Florida State University researcher has developed a model to help stakeholders figure out what factors they need to consider to rebuild land in coastal Louisiana.
Notre Dame researchers found that firms operating regionally through downstream commercialization activities can offer complementary assets to the upstream R&D activities that help protect the firms’ intellectual property.
Scientists at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have combined two different microscope technologies to create sharper images of rapidly moving processes inside a cell.
Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center. The preclinical study suggests that mutations in ARID1a could be beneficial in predicting immunotherapy success.
A new study by Sanford Burnham Prebys (SBP) researchers describes how a specific nuclear pore component is critical for the survival of circulating T cells. The findings, published in Nature Immunology, identify a new node of T cell receptor signaling and could pave the way for the development of future immunotherapies.
With unprecedented demographic trends leading to an aging workforce, a new emphasis on productive aging is needed to keep US workers of all generations as healthy and productive as possible, according to an article in the May Journal of Occupational and Environmental Medicine.
In the spring of 2017, 12,146 individuals with hypothyroidism responded to an online survey posted on a variety of websites and social media for two months by the Program Committee of the Satellite Symposium on Hypothyroidism, organized by the American Thyroid Association (ATA). The ATA Hypothyroidism Treatment Survey asked responders to answer questions about demographic data, their satisfaction with treatments and their physicians, their perceptions of the physicians’ knowledge about hypothyroidism treatments, the need for new treatments, and the impact of hypothyroidism on their lives, among others.
A review of nearly 500 cases of infants with severe congenital hyperinsulinism who underwent partial or near-total removal of their pancreas for persistent hypoglycemia at Children’s Hospital of Philadelphia (CHOP) showed that surgeons can cure virtually all patients with the focal, or localized, form of the rare genetic disease.
While on-the-job fatalities due to injuries and accidents have steadily decreased in nearly every industry in the U.S., the burden of debilitating lung disease in the coal mining industry has sharply increased within the last decade. A new study published in Risk Analysis: An International Journal examines whether compliance with health regulations at mines across the country was sufficient to decrease instances of lung disease.
Jedediah Purdy, Robinson O. Everett Professor of Law at Duke University Law School, will deliver “This Land is Our Land: Nature and Nationalism in the Age of Trump,” a free public lecture, on Fri., May 11.
For millions of Americans who are obese and living with diabetes, feelings of sadness, anger and anxiety are often part of daily life. A new Iowa State University study suggests those negative feelings may stem from problems regulating blood sugar levels that influence emotional response in the brain.
To make open offices less noisy, researchers are creating small “acoustic islands” using high-back chairs and retroreflective ceilings to direct sound to help you hear your own conversations -- not others’ -- better. During the 175th ASA Meeting, Manuj Yadav, at the University of Sydney, will present his and his colleagues’ work toward solutions to the speech distraction problem in open-plan offices.
A new study from the UNC Lineberger Comprehensive Cancer Center shows that parenting concerns have a significant impact on the mental and emotional health of women with advanced cancer. In particular, they found that a mother’s emotional well-being was significantly linked with whether she had communicated with her children about her illness, and her concerns about how her illness will financially impact her children.
Self-reported gun carrying among high school freshmen, sophomores increased in Chicago between 2007 and 2013, decreased in Los Angeles, remained flat in New York City
African-American male students most likely to report carrying a gun
Chicago had higher rates of reported fights and students feeling unsafe in school
A new Johns Hopkins Medicine analysis of national trauma data shows that trauma patients were four times more likely to die from gunshot wounds and nearly nine times more likely to die from stab wounds before getting to a trauma center in 2014, compared with rates in 2007.
The University of Notre Dame study also indicates that nearly a quarter of dengue virus transmission is the result of mosquitoes biting those already infected before the onset of symptoms.
The use of discarded/rejected precast concrete represents a significant opportunity as a source for clean recycled concrete aggregates with consistent properties and high quality.
The precision of measuring nanoscopic structures could be substantially improved, thanks to research involving the University of Warwick and QuantIC researchers at the University of Glasgow and Heriot Watt University into optical sensing.
Vivex Biomedical, Inc. (Vivex) is pleased to announce the publication of a peer-reviewed study examining the use of its cellular bone matrix product, VIA Graft, for spinal fusion surgery. The peer-reviewed study was published in the January edition of the International Journal for Spine International Journal for Spine Surgery, and demonstrates exceptional clinical results.
Parents of twins and other multiple-birth children experience higher than average rates of depression, anxiety and other mental health issues, particularly during the first three months, according to a survey study in the May issue of Journal of Psychiatric Practice. The journal is published by Wolters Kluwer.
Scientists studying tumor growth and metastasis at the University of Notre Dame fabricated a human tissue model to examine how cancer cells interact with connective tissue in the breast.
James Eberwine, PhD, the Elmer Holmes Bobst Professor of Systems Pharmacology and Translational Therapeutics is part of an international team of researchers, who will receive $1.25M over the next three years to better understand oxidative phosphorylation (OxPhos), a biological system that plays a key role in the production of energy, generation of free radicals, and cell death.
Researchers at the National Eye Institute have discovered cellular mechanisms that help the 13-lined ground squirrel survive hibernation. Their findings could be a step toward extending storage of human donor tissues awaiting transplantation and protecting traumatic brain injury patients who undergo induced hypothermia. NEI is part of the National Institutes of Health. The findings were published in the May 3 issue of Cell.
Non-White scholars continue to be underrepresented in publication rates, citation rates, and editorial positions in communications and media studies, finds a new study by NYU Steinhardt School of Culture, Education, and Human Development and published in the Journal of Communication. This has negative professional implications both for non-White scholars, in terms of contract renewals, tenure and promotion, and for the field in general, in terms of the visibility of and attention to the knowledge produced.
Research at UT Southwestern has shown that targeting metabolism in growing cells holds promise for the treatment of skin diseases like psoriasis that are characterized by skin overgrowth resulting from excess cell division, known as hyperproliferation.
With the unexpected discovery of a panel of peptides from several proteins encoded by the parasite that causes malaria, new research underway at Seattle Children’s Research Institute could pave the way for a rapid screening test capable of diagnosing submicroscopic infections.
According to Notre Dame researchers, global applications are significant when considering those populations without suitable drinking water and limited resources.
The urine of kidney disease patients contains a diverse mix of bacteria such as Staphylococcus and Streptococcus, a Loyola University Chicago study has found. The findings could lead to new approaches to treating lower urinary tract problems such as urinary urgency and incontinence.
A Loyola Medicine study has found that 15.4 percent of patients who take "drug holidays" from osteoporosis drugs experienced bone fractures. During a six-year follow-up period, the yearly incidence of fractures ranged from 3.7 percent to 9.9 percent, with the most fractures occurring during the fourth and fifth years.
A non-twisting laser beam moving through magnetized plasma turns into an optical vortex that traps, rotates, and controls microscopic particles, opening new frontiers in imaging.
Conventional memory devices use transistors and rely on electric fields to store and read out information. An alternative approach uses magnetic fields, and a promising version relies on the magnetoelectric effect which allows an electric field to switch the magnetic properties of the devices. Existing devices, however, tend to require large magnetic and electric fields. One potential solution is a new switching element made from chromia. The researchers report their findings in Applied Physics Letters.
Researchers in China have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, an aggressive form of the disease that is largely untreatable. But the study, which will be published May 4 in the Journal of Experimental Medicine, reveals that the widely used osteoporosis drug zoledronic acid inhibits UGT8 and prevents the spread of basal-like breast cancer in mice, suggesting that this drug could also be used to treat the disease in humans.
In a new SLAS Discovery auto-commentary, two authors of an article recently published in eLife (“LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle”) explain their general views on their novel discoveries and discuss ideas on the relevant new questions generated by their data.