People who owned black-and-white television sets until the 1980s didn’t know what they were missing until they got a color TV.
A human cell harbors roughly 2 meters of DNA, encompassing the essential genetic information of an individual. If one were to unwind and stretch out all the DNA contained within a single person, it would span a staggering distance – enough to reach the sun and back 60 times over.
Recently, Providencia spp. which have been detected in patients with gastroenteritis, and similar to enterohemorrhagic Escherichia coli. O157 and Salmonella spp., have been attracting attention as causative agents of food poisoning.
It’s not easy to distinguish between the dozens of subtypes of limb girdle muscular dystrophy — a rare, genetic muscle disease characterized by weakness in the hips and shoulders that causes difficulty walking and lifting the arms.
Danny Reinberg, Ph.D., one of the world’s foremost biochemists, is joining Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, bringing decades of ground-breaking research in genetics, epigenetics and cellular processes.
Scientists at City of Hope have developed universal donor stem cells that could one day provide lifesaving therapy to children with lethal brain conditions, such as Canavan disease, as well as to people with other degenerative diseases, such as Alzheimer’s and multiple sclerosis.
Researchers have discovered a mechanism for COVID-19 susceptibility using a newly created tool.
A team of scientists – including UC Irvine’s Distinguished Professor of Ecology & Evolutionary Biology Brandon Gaut and UC Davis’ Professors of Viticulture & Enology Dario Cantù and Andy Walker – has made a significant breakthrough in the battle against a devastating disease affecting grapevines.
UC San Diego scientists discover shattered chromosomal fragments are tethered together during cell division before being rearranged; destroying the tether may help prevent cancerous mutations.
Researchers at Washington University School of Medicine in St. Louis have developed an approach that could help doctors distinguish between the many subtypes of limb girdle muscular dystrophy, a rare, genetic muscle disease. With new therapies poised to enter the clinic, identifying the precise subtype is necessary to ensure that people get access to the treatment most likely to benefit them.
Researchers from the Perelman School of Medicine at the University of Pennsylvania have invented a new way to map specific DNA markings called 5-methylcytosine (5mC) which regulate gene expression and have key roles in health and disease. The innovative technique allows for scientists to profile DNA using very small samples and without damaging the sample which means it can potentially be used in liquid biopsies (testing for cancer markers in the bloodstream) and early cancer detection.
New research is bolstering scientific understanding behind why some people are more prone to allergies than others. Researchers in the Perelman School of Medicine at the University of Pennsylvania identified how genetic differences that alter a specific protein called ETS1 can affect our body's response to allergies. They found that small changes in ETS1 in an animal model can lead to an increased likelihood for allergic reactions that cause inflammation. The findings were published recently in Immunity.
Hackensack Meridian Neuroscience Institute at Jersey Shore University Medical Center’s ALS Center is the first in New Jersey to provide patients with QALSODY™ (tofersen), the first treatment to target a genetic cause of the disease. The U.S. Food and Drug Administration (FDA) approved the QALSODY (tofersen) injection in April 2023, for the treatment of amyotrophic lateral sclerosis (ALS) in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene.
A new paper in Molecular Biology and Evolution, published by Oxford University Press, shows that a condition known as Dupuytren's disease is partly of Neandertal origin.
Scientific discoveries on Hereditary Cancer Syndromes have evolved in recent years, with advances in understanding the genetic basis of various tumors and the biological underpinnings of inherited cancer syndromes.
In a recent article published in the journal Nature Communications, Binghamton University Assistant Professor of Biological Sciences Adam Session and Daniel S. Rokhsar, a professor of genetics, evolution and development at the University of California, Berkeley, outline a way to trace these genomes back to the polypoid hybrid’s parent species.
The Association for Molecular Pathology (AMP) today awarded Xavier Becerra, US Secretary of the Department of Health and Human Services, with its Champion for Innovation Award. Secretary Becerra was recognized for his 30-year career in public service and his ongoing commitment to protecting patient access to high-quality, affordable care. The award presentations coincides with the 10th anniversary of the Supreme Court’s landmark decision invalidating gene patents in Association for Molecular Pathology et al. v. Myriad Genetics, Inc. et al.
Genetic variation is the ultimate fuel for evolution, says Utah State University evolutionary geneticist Zachariah Gompert. But, over centuries, that fuel reservoir gets depleted in the course of natural selection and random genetic drift.
Miscanthus thrives on marginal lands with limited fertilization and tolerates drought and cool temperatures, making it an ideal bioenergy candidate. Previous efforts to genetically improve miscanthus focused on introducing external genes at random places in the plant’s genomes. This research developed gene-editing procedures using CRISPR/Cas9 that will allow scientists to selectively target existing genes to knock out their function and introduce new genes into precise locations.
In a recent study published in the journal Biology Letters, a female crocodile living in isolation for 16 years at a Costa Rican zoo laid a clutch of eggs, a common practice among captive reptiles, even those without mates. After three months of incubation, one egg contained "a fully formed stillborn baby crocodile," a team of scientists found.
Not enough people are getting genetic testing for cancer, according to recent research.
A new study by researchers at The University of Texas MD Anderson Cancer Center highlights novel insights into the evolution of multiple myeloma from precursor disease, which may help better identify patients likely to progress and develop new interventions
Researchers presenting preliminary data from a clinical trial aimed at discovering a cure for sickle cell disease reveal positive results among its first patients. Sickle cell disease, a genetic blood disorder, is a painful and debilitating condition for which there are few approved therapies.
Rich DiPaolo, Ph.D., professor and interim chair in the Department of Molecular Microbiology and Immunology, warns that patients with gastritis caused by autoimmunity as well as Helicobacter pylori, a type of bacteria that infects your stomach, may benefit from routine screenings to identify patients with a high risk of progressing to gastric cancer.
Biologists have identified a previously unknown way that our immune system detects viruses. The immune protein CARD8 acts as a trip wire to detect a range of viruses, including the virus that causes COVID. They also found that CARD8 functions differently among species and varies between humans.
The research group of Professor Kamimura in Niigata University have applied the novel, liver lobe-specific hydrodynamic delivery procedure to primates (baboons) for the first time.
Recent scientific discoveries have shown that Neanderthal genes comprise some 1 to 4% of the genome of present-day humans whose ancestors migrated out of Africa, but the question remained open on how much those genes are still actively influencing human traits — until now.
Working with live squid hatchlings at Scripps Institution of Oceanography, UC San Diego scientists find the animals can tune their proteome on the fly in response to changes in ocean temperature via the unique process of RNA recoding. The findings inspire new questions about basic protein function.
La insuficiencia renal puede tener diversas causas: diabetes, presión arterial alta, enfermedades autoinmunitarias y enfermedad renal poliquística o ERP.
A insuficiência renal pode ser causada por diversos motivos: diabetes, pressão arterial elevada, doenças autoimunes e doença renal policística ou DRP.
قد ينتج الفشل الكلوي عن عدة أسباب منها، السكري وارتفاع ضغط الدم، وأمراض المناعة الذاتية، وداء الكلى متعددة الكيسات.
A genomic analysis of ancient human remains from Morocco in northwest Africa revealed that food production was introduced by Neolithic European and Levantine migrants and then adopted by local groups.
More than 5,000 people are diagnosed annually with ALS (amyotrophic lateral sclerosis), a fatal, neurodegenerative disease that attacks nerve cells in the brain and spinal cord, gradually robbing people of the ability to speak, move, eat and breathe.
IIT Kanpur has licensed a pioneering technology to Reliance Life Sciences Pvt. Ltd. that has the potential to revolutionize the field of gene therapy, especially for many genetic eye diseases, making it the first time that a gene therapy related technology has been developed and transferred from an academic institution to a company in India.
Researchers at the University at Albany’s RNA Institute have demonstrated a new approach to DNA nanostructure assembly that does not require magnesium. The method improves the biostability of the structures, making them more useful and reliable in a range of applications.
The first gene mapping study on eyebrow thickness in Europeans discovered three previously unreported genetic loci, as reported in a Letter to the Editor in the Journal of Investigative Dermatology, published by Elsevier.
Fundamental research offers opportunities for new varieties of pigmented rice and a resource to address malnutrition.
Artificial intelligence has entered our daily lives. First, it was ChatGPT. Now, it’s AI-generated pizza and beer commercials. While we can’t trust AI to be perfect, it turns out that sometimes we can’t trust ourselves with AI either.
An observational cohort study out of Roswell Park Comprehensive Cancer Center demonstrates that race and ethnicity affect a woman’s 21-gene recurrence score, a tool used to determine risk of recurrence and distant metastasis in patients with early-stage, hormone-receptor-positive breast cancer. Based on the expression of 21 cancer-related genes detected in pre-treatment tumor specimens, recurrence score is used routinely in clinical care to identify patients who might benefit from chemotherapy as part of their treatment plan. Scores range from 0-100, with a score of 26 or higher indicating greater risk of recurrence and poorer overall survival.
Genes that make bacteria resistant to antibiotics are much more widespread in our environment than was previously realised.
Staying active could help keep the onset of type 2 diabetes at bay, even if someone has a genetic risk of developing the disease. Researchers say this highlights the importance of exercise in chronic disease prevention.
This study used two DNA methylation-based estimators, known as epigenetic clocks, to examine aging at the cellular level and estimate the difference between chronological age and biological age. Findings showed that neighbourhood deprivation and depressive symptoms were positively associated with acceleration of the epigenetic age estimated using the DNAm GrimAge clock.
The world should be prepared to respond to a disease outbreak of “even deadlier potential” than COVID-19, the head of the WHO said after the UN agency launched a global network to monitor disease threats.
An international team of marine biologists has discovered the remnants of ancient RNA viruses embedded in the DNA of symbiotic organisms living inside reef-building corals.
Unlocking the potential of laboratory-crafted DNA, known as synthetic DNA, holds the key to groundbreaking advancements across multiple domains, according to quantum biologists from the University of Surrey.
So far, it has not been possible to explain the causes of around half of all rare hereditary diseases. A Munich research team has developed an algorithm that predicts the effects of genetic mutations on RNA formation six times more precisely than previous models. As a result, the genetic causes of rare hereditary diseases and cancer can be identified more precisely.
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