A combination strategy of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) with chemotherapy for pancreatic cancer will be studied at UTHealth Houston through a $3.3 million grant from the National Cancer Institute by the U.S. Department of Health and Human Services.
It is a scary fact that one in two women and one in three men in the United States will develop some form of cancer in their lifetime. One of the hallmarks of many cancers is the occurrence of errors during the cell division process called mitosis. Therefore, critical to enhancing treatments or perhaps even finding a cure for cancer and other diseases, is developing a better understanding of how mitosis works in both healthy and diseased cells.
Japanese biochemist and molecular biologist Noboru Mizushima, M.D., Ph.D., has been named the inaugural recipient of the Beth Levine, M.D. Prize in Autophagy Research from UT Southwestern Medical Center. Dr. Mizushima is an internationally recognized scientist who has made significant strides in unraveling the complex processes of mammalian autophagy, a fundamental cellular mechanism responsible for maintaining cellular health and functionality.
New study shows that cholesterol aggregates can promote SARS-CoV-2 infection to help the virus invade cells
The 2023 Warren Alpert Foundation Prize has been awarded to scientist David J. Lipman for his visionary work in the conception, design, and implementation of computational tools, databases, and infrastructure that transformed the way biological information is analyzed and accessed freely and rapidly around the world.
Black people have the highest death rate and shortest survival rate of any racial or ethnic group for most cancers, according to the American Cancer Society. These disparities are driving many efforts to raise awareness about cancer prevention and care in Black communities, such as Black Family Cancer Awareness Week, which takes place June 15–21.
People who owned black-and-white television sets until the 1980s didn’t know what they were missing until they got a color TV.
A human cell harbors roughly 2 meters of DNA, encompassing the essential genetic information of an individual. If one were to unwind and stretch out all the DNA contained within a single person, it would span a staggering distance – enough to reach the sun and back 60 times over.
Cedars-Sinai investigators have identified several steps in a cellular process responsible for triggering one of the body’s important inflammatory responses. Their findings, published in the peer-reviewed journal Science Immunology, open up possibilities for modulating the type of inflammation associated with several infections and inflammatory diseases.
Recently, Providencia spp. which have been detected in patients with gastroenteritis, and similar to enterohemorrhagic Escherichia coli. O157 and Salmonella spp., have been attracting attention as causative agents of food poisoning.
New research published in the Journal of Clinical Investigations confirms that microglial cells – which are specialized immune cells with a decade-long lifespan in the brain - can serve as a stable viral reservoir for latent HIV.
Danny Reinberg, Ph.D., one of the world’s foremost biochemists, is joining Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, bringing decades of ground-breaking research in genetics, epigenetics and cellular processes.
Scientists at City of Hope have developed universal donor stem cells that could one day provide lifesaving therapy to children with lethal brain conditions, such as Canavan disease, as well as to people with other degenerative diseases, such as Alzheimer’s and multiple sclerosis.
The University of California, Irvine has received a five-year, $10 million grant from the National Institutes of Health to lead a multi-institutional study of specific brain cell vulnerabilities to abnormal tau protein deposits in regions affected in the early stages of Alzheimer’s disease.
A new study from researchers at the University of Wisconsin–Madison offers a first-of-its-kind visual of a non-mammal species' adaptive immune system in action. The advance holds potential implications for a range of scientific aims, from improving wildlife vaccines to better understanding fundamental disease processes and possibly the evolution of adaptive immunity itself.
UC San Diego scientists discover shattered chromosomal fragments are tethered together during cell division before being rearranged; destroying the tether may help prevent cancerous mutations.
As we enter the summer months in the Northern Hemisphere and the possibility of extreme heat becomes more common, it’s important to stay up-to-date on the science of heat waves and take measures to protect ourselves from this growing public health threat.
All living cells contains proteins with different functions, depending on the type of cell. Researchers at the University of Gothenburg have discovered a way to identify proteins even without looking at their structure.
University of Queensland researchers have used an algorithm from a video game to gain insights into the behaviour of molecules within live brain cells.
Researchers have used heart and lung stem cells infected with the virus that causes COVID-19 to better understand how the disease impacts different organs, paving the way for more targeted treatments.
Researchers from Children’s Hospital of Philadelphia (CHOP) have engineered stable, universal MHC-I molecules that can be produced rapidly at scale, allowing researchers not only to develop vaccines and immunotherapies more quickly but also to identify molecules that can work broadly across the population. The findings were published today in the Proceedings of the National Academy of Sciences.
Prostate cancer is the most-commonly diagnosed malignancy and the second leading cause of cancer death among men in the United States. In its ever-indelicate world, the stubborn disease can continue to grow even when the amount of testosterone in the body is reduced to very low levels, thus earning the clumsy name: castrate-resistant prostate cancer (CRPC).
A new acoustic microfluidic method offers opportunities to conduct experiments with swimming cells and microorganisms. With it, ultrasonic waves like those used for imaging are able to hold a cell’s body in place without affecting the way it swims.
Researchers at Texas Biomedical Research Institute have succeeded in generating the lung’s most important immune cell, the alveolar macrophage, in the lab.
Perhaps the most obvious feature of a neuron is the long branch called an axon that ventures far from the cell body to connect with other neurons or muscles.
A new study by researchers at The University of Texas MD Anderson Cancer Center highlights novel insights into the evolution of multiple myeloma from precursor disease, which may help better identify patients likely to progress and develop new interventions
A new study in mice, led by researchers at Washington University School of Medicine in St. Louis, explains how prostate cancer senses a drop in testosterone levels due to common anti-hormone therapy and then begins making cholesterol — a necessary precursor to testosterone — to generate its own testosterone to fuel tumor growth. The study also points to a possible drug combination that may stop the cancer from feeding its own growth.
Scientists at Brookhaven Lab have determined the atomic-level structure of a zinc-transporter protein, a molecular machine that regulates levels of this crucial trace metal micronutrient inside cells. The structure reveals how the cellular membrane protein shifts its shape to move zinc from the environment into a cell, and temporarily blocks this action automatically when zinc levels inside the cell get too high.
Researchers presenting preliminary data from a clinical trial aimed at discovering a cure for sickle cell disease reveal positive results among its first patients. Sickle cell disease, a genetic blood disorder, is a painful and debilitating condition for which there are few approved therapies.
Rich DiPaolo, Ph.D., professor and interim chair in the Department of Molecular Microbiology and Immunology, warns that patients with gastritis caused by autoimmunity as well as Helicobacter pylori, a type of bacteria that infects your stomach, may benefit from routine screenings to identify patients with a high risk of progressing to gastric cancer.
Working with live squid hatchlings at Scripps Institution of Oceanography, UC San Diego scientists find the animals can tune their proteome on the fly in response to changes in ocean temperature via the unique process of RNA recoding. The findings inspire new questions about basic protein function.
An electron microscopy study revealed key details of actin filaments, which are essential structural elements of cells and muscles
Researchers at The University of Queensland have discovered viruses such as SARS-CoV-2 can cause brain cells to fuse, initiating malfunctions that lead to chronic neurological symptoms.
A new study led by Yale Cancer Center shows improved rates of survival and reduced risk of recurrence in patients with non-small cell lung cancer taking osimertinib (TAGRISSO), a targeted therapy, following surgery. Non-small cell lung cancer (NSCLC), the most common type of lung cancer, tends to recur when diagnosed at advanced stages, which makes treatment challenging.
Targeted alpha therapy using radioisotopes such as actinium-225 can destroy cancerous cells without harming healthy cells. However, making actinium-225 by bombarding radium targets with neutrons poses a challenge: how to chemically separate the radium from the actinium. A new approach uses radiation-resistant inorganic resin scaffolds as platforms for separating radium, actinium, and lead, improving production time, cost, and safety.
More than 5,000 people are diagnosed annually with ALS (amyotrophic lateral sclerosis), a fatal, neurodegenerative disease that attacks nerve cells in the brain and spinal cord, gradually robbing people of the ability to speak, move, eat and breathe.
They’re a marine delicacy loved across Asia, but the humble sea cucumber is also proving to be a key ingredient in preventing diabetes, according to new research from the University of South Australia.
Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma.
Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers.
Scientists from the National University of Singapore have invented a powerful tool that captures data on immune cell response at a single-cell level. This groundbreaking technique will accelerate the discovery of new immunotherapies to treat diseases such as cancer, autoimmune disorders, and infectious diseases.
Researchers at the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) have discovered a phase shift between chaotic states that can appear in herds of animals and, in particular, in swarms of insects. This advance may help to better understand their behaviour or be applied to the study of the movement of cells or tumours.
Research has shown that the immune system doesn’t function properly in patients with multiple myeloma, a blood cancer that occurs when plasma cells — a type of white blood cell — multiply out of control. But a clinical trial led by Jens Hillengass, MD, PhD, Chief of Myeloma at Roswell Park Comprehensive Cancer Center, shows that exercise may have the power to strengthen the immune system in those patients, providing a non-pharmaceutical method of helping control the disease.
Patients with early relapsed or refractory large B-cell lymphoma had significantly improved overall survival when treated with the chimeric antigen receptor (CAR) T cell therapy axicabtagene ciloleucel (axi-cel) when compared to the current standard-of-care chemoimmunotherapy, according to results of the Phase III ZUMA-7 trial reported by researchers from The University of Texas MD Anderson Cancer Center.
According to the federal government’s National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide — with almost a third in the United States — are living with multiple sclerosis (MS), a disabling neurological disease in which the body’s immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.
A tiny population of T-cells could serve as a much-needed biomarker—and a potential therapeutic target—for pediatric acute liver failure, according to new research from Children’s Hospital Los Angeles.
ASBMB travel awards support biomedical research projects and career development for trainees from Argentina, Chile, Mexico, Uruguay and Spain to work in labs in North America
Researchers from the Center for Cognition and Sociality (CCS) within the Institute for Basic Science (IBS) recently announced the discovery of neurons that allow us to recognize others. The research team discovered that the neurons that deal with the information associated with different individuals are located in the CA1 region of the hippocampus.
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