Worms might not be depressed, per se. But that doesn’t mean they can’t benefit from antidepressants.
REBYOTA is indicated for the prevention of recurrence of Clostridioides difficile (C. diff) infection in individuals 18 years of age and older, following antibiotic treatment for recurrent C. diff infection.
A new phase III study has demonstrated the efficacy of trastuzumab deruxtecan (Enhertu) in patients with HER2-positive metastatic breast cancer whose cancers were resistant to previous treatment with trastuzumab emtansine. Both trastuzumab deruxtecan and trastuzumab emtansine are antibody-drug conjugates, a relatively new type of drug that delivers chemotherapy directly to the cancer cell, minimizing damage to normal tissues.
Strategies to treat pain without triggering dangerous side effects such as euphoria and addiction have proven elusive. Now scientists at Washington University School of Medicine have identified a potential pathway to pain relief that neither triggers addiction nor causes hallucinations.
With an emphasis on reaching the entire spectrum of allied health professionals working within primary care, Philadelphia College of Osteopathic Medicine (PCOM) is launching its first peer-reviewed scientific journal, the Journal of Integrated Primary Care (JIPC).
A new study found a declining proportion of DATA-waivered clinicians prescribed any buprenorphine between 2017 and 2021. While the number of waivered clinicians increased significantly during the five-year window, only one out of three prescribed any buprenorphine as of May 2021. Furthermore, the majority of prescriptions were written by clinicians who specialize in treating opioid use disorder. The new study was published as a research letter in JAMA.
New research highlights potential safety concerns around women taking romosozumab, a new anti-osteoporosis drug available on the NHS. The University of Bristol-led study, published in Arthritis & Rheumatology, analysed genetic data on nearly 34,000 people.
Renowned pharmacoepidemiologist, Dr. Tobias Gerhard, is named new director of the Rutgers Institute for Health, Health Care Policy and Aging Research.
For millions of Americans that suffer from seasonal allergies (pollen and mold), climate change is exacerbating an earlier, longer, and overall worse allergy season.
Psilocybin is a hallucinogenic compound found in about 200 mushroom species, including the liberty cap (Psilocybe semilanceata).
Researchers have used Argonne’s Advanced Photon Source to characterize a set of broadly neutralizing antibodies effective against a wide range of coronaviruses.
At the end of 2022, the federal government eliminated the “X waiver,” a major hurdle to providing addiction treatment, but progress needs to be continued, according to the authors of a new Perspective piece published in the New England Journal of Medicine.
A new study conducted by researchers from Regenstrief Institute and the universities of South Carolina and Indiana has found that the most commonly prescribed blood pressure medications, taken for at least six months prior to an intensive care unit (ICU) admission, did not protect against developing delirium in the ICU, regardless of patient age, gender, race, co-morbidities or insurance status.
Safer cancer drugs are now one step closer after a new study led by UCL (University College London) researchers found the likely reason that some treatments damage the heart.
Research supports the promise of psychedelics in treating conditions like depression and post-traumatic stress disorder, but the future regulatory landscape for these drugs remains unclear. Experts from Baylor College of Medicine, the University of Pennsylvania, American University and Harvard Law School call for creativity and collaboration at the federal and state levels in developing policies for the use and oversight of psychedelics and a commitment to developing a strong evidence base for efficacy and safety.
A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A). This structure and other findings in the new study could be harnessed to engineer new BoNT/E variants with modified specificities toward different SV2 isoforms for new clinical developments.
Researchers at Johns Hopkins University School of Medicine say they have evidence from a new study in rats that spinal cord stimulation (SCS) may be useful in reducing chronic pain in people undergoing active treatment with a common anti-cancer drug.
Kyowa Kirin, Inc., an affiliate of Kyowa Kirin Co., Ltd. (Kyowa Kirin, TSE: 4151), a top 50 global specialty pharmaceutical company, today assumes primary commercial leadership for CRYSVITA® (burosumab-twza) injection in the United States and Canada from Ultragenyx Pharmaceutical, Inc., a transition planned for from the start of their decade-long collaboration.
For breast cancer patients undergoing breast reconstruction after mastectomy, avoiding postoperative oral antibiotics does not reduce the risk of infections, reports a study in the May issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.
MD Anderson and Generate:Biomedicines announced a co-development and commercialization agreement to accelerate novel protein therapies using generative AI.
The April 2023 issue of SLAS Discovery contains six full-length articles and one mini-review covering high-throughput screening (HTS) for protease-inhibiting drugs, high-content phenotypic screening and other life sciences research.
As a result of demographic change, the proportion of older oncology patients is rising sharply. Compared to younger patients, cancer treatment is highly individualised due to more frequent and sometimes severe comorbidities, increasing age-related infirmities and reduced physical fitness.
Most medical AI models in use today are trained to perform one or two specific tasks and have limited utility.
Safer and more effective blood thinners could be on the way following a groundbreaking discovery by researchers at UBC and the University of Michigan, published today in Nature Communications.
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Researchers reporting in ACS Central Science have now developed a system that directly targets and degrades the SARS-CoV-2 viral RNA genome, reducing infection in mice. The method could be adapted to fight off many viruses, as well as treat various diseases.
Treating opioid addiction should be much easier now than it was a few years ago, thanks to pandemic-era rule changes that aim to improve access to buprenorphine, a medicine proven to help in recovery. But a new study shows prescriptions and adherence rates have remained flat.
A study led by the Michigan Psychedelic Center at the University of Michigan Medical School takes a closer look at the neurobiology of psychedelic experiences caused by nitrous oxide, ketamine and LSD.
UCLA Health investigators are leading a new, six-city trial of injectable buprenorphine for treatment of methamphetamine use disorder in adults who also use opioids.
As the movement toward “deprescribing” medications among older adults grows, a new poll shows strong interest in this idea, with 80% of adults aged 50 to 80 open to stopping one or more of the prescription medicines they’ve been taking for more than a year, if a health care provider said it was possible. Already, 26% said they have done so in the past two years - though some had done it without talking to a health provider.
UC San Diego researchers describe a key player in the defense mechanism that safeguards against excessive insulin in the body, which can be as harmful as too little.
Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.
Opioids are commonly prescribed as an all-purpose pain killer for patients with the condition
The drug atogepant may help prevent migraines for people who have had no success with other preventive drugs, according to a preliminary study released April 20, 2023, which will be presented at the American Academy of Neurology’s 75th Annual Meeting being held in person in Boston and live online from April 22-27, 2023. The study involved people with episodic migraine, which is defined as having up to 14 headache days per month with migraine characteristics.
A new study from researchers at Cummings School of Veterinary Medicine at Tufts University and Tufts Medical Center reports that heart tissue obtained through organ donations from dogs dying of other causes are a promising platform for testing cancer drug toxicity, offering scientists a new alternative.
Two doses of an FDA-approved sleeping pill reduced levels of Alzheimer’s proteins in a small study of healthy volunteers led by researchers at Washington University School of Medicine in St. Louis. The study hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease, although much more work needs to be done to confirm the viability of such an approach.
Researchers from Johns Hopkins University published a new Journal of Marketing article that examines how receiving negative medical results might affect how people choose between generic and brand name drugs.
Scientists in Melbourne have designed a new type of oral capsule that could mean pain-free delivery of insulin and other protein drugs.
A drug called teriflunomide may delay first symptoms for people whose magnetic resonance imaging (MRI) scans show signs of multiple sclerosis (MS) even though they do not yet have symptoms of the disease. The preliminary study, released April 19, 2023, will be presented at the American Academy of Neurology’s 75th Annual Meeting, being held in person in Boston and live online from April 22-27, 2023. Called radiologically isolated syndrome, the condition is diagnosed in people who do not have MS symptoms but who have abnormalities in the brain or spinal cord called lesions, similar to those seen in MS.
Thanks to a recent upgrade to the medical isotope facilities at Brookhaven National Laboratory, actinium-225 (Ac-225), an isotope that shows great promise for treating cancer, can now be produced, purified, and shipped ready for use directly from the Lab. The first shipment left Brookhaven in mid-March.
Up to 70 percent of patients in ICUs receive antibiotic therapy on any given day, and 30 to 60 percent of those prescriptions are unnecessary. A study in U.S. ICUs reveals that there continues to be an “antibiotic culture,” meaning that the preference for antibiotics is related to their perceived role as “magic bullets.” Findings showed a context-specific culture of antibiotic prescribing most closely associated with the patient load and ICU processes. Antibiotic prescribing was shaped by urgency, hierarchy and uncertainty.
Researchers have identified a strong association between prevalence of prescription stimulant therapy for attention-deficit/hyperactivity disorder (ADHD) and rates of prescription stimulant misuse (taken in a way other than as directed by a clinician) by students in middle and high schools.
Brand-name drugs cost two to three times more in the U.S. than in other countries, but many of the top-selling brand name drugs may provide little added therapeutic benefit. A new study led by researchers at Brigham and Women’s Hospital, a founding member of Mass General Brigham, used public Medicare data to identify the 50 highest-selling brand-name drugs in 2020.
Researchers from The University of Texas MD Anderson Cancer Center presented promising findings from multiple clinical trials today at the American Association for Cancer Research (AACR) Annual Meeting 2023. The studies, which describe results from a novel FGFR inhibitor and from new PARP/ATR inhibitor combinations, were featured in a plenary session highlighting novel biomarker-driven molecularly targeted therapy trials.
Based on a large retrospective study, Roswell Park Comprehensive Cancer Center experts that many patients with early-stage breast cancer with rare variant histology, or tumor anatomy, benefit from chemotherapy.
Researchers have developed a drug that undercuts antibiotic resistance
A prescrição de opioides tem um efeito negativo na função cognitiva em adultos idosos, de acordo com um estudo recente da Mayo Clinic, publicado na revista Journal of the American Geriatrics Society.
El uso de la prescripción de opioides puede tener un efecto negativo en la función cognitiva de los adultos mayores de acuerdo con un estudio reciente de Mayo Clinic publicado en la revista de la Sociedad Estadounidense de Geriatría.
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