Scientists at The Scripps Research Institute (TSRI) have found a way to change leukemia cells into leukemia-killing immune cells. The surprise finding could lead to a powerful new therapy for leukemia and possibly other cancers.
SBP researchers and colleagues discover a mechanism that regulates the aging and abundance of secreted proteins
When a Lake Malawi cichlid loses a tooth, a new one drops neatly into place as a replacement. Why can't humans similarly regrow teeth lost to injury or disease?
A new genetic discovery could help scientists understand exactly how one X chromosome in each cell of a female's body gets "silenced" – and perhaps lead to better treatment for X-linked diseases.
A group of researchers from five national laboratories, led by the U.S. Department of Energy's Argonne National Laboratory, are collaborating in a project called "Mapping the Protein Universe."
Writing in Scientific Reports, researchers led by a group from Roswell Park Cancer Institute have shared new insights about a subset of T cells that appear to both inhibit cancer growth and enhance the tumor-killing powers of other immune cells.
Different treatments for Crohn's disease in children affects their gut microbes in distinct ways, which has implications for future development of microbial-targeted therapies for these patients.
A team led by Brown’s George Karniadakis, is using the Cray XK7 Titan supercomputer to simulate hundreds of millions of red blood cells in an attempt to develop better drug delivery methods and predictors to fight against tumor formation and sickle cell anemia.
A study led by Indiana University biologist Patricia Foster and colleagues has found that forces in the external environment and oxidation are the greatest threats to an organism’s ability to repair damage to its own DNA.
If you take certain atoms and make them almost as cold as they possibly can be, the atoms will fuse into a collective low-energy quantum state called a Bose-Einstein condensate. In 1968 physicist Herbert Fröhlich predicted that a similar process at a much higher temperature could concentrate all of the vibrational energy in a biological protein into its lowest-frequency vibrational mode. Now scientists in Sweden and Germany have the first experimental evidence of such so-called Fröhlich condensation. They report their results in the journal Structural Dynamics.
The Association of American Cancer Institutes will present the AACI Distinguished Scientist Award to Lewis Cantley, PhD, on October 26, during the 2015 AACI/CCAF Annual Meeting, in Washington, DC.
A new survey of almost 450 biomedical researchers from every major stakeholder group (e.g., academia, industry) conducted by the Global Biological Standards Institute (GBSI) shows little has changed in cell line authentication and culture practices in the past decade—practices that contribute to irreproducible research, and delays and increased costs of drug discovery. The results are detailed in The culture of cell culture practices and authentication—Results from a 2015 Survey, by Leonard P. Freedman, Ph.D., lead author, published today in the open access journal BioTechniques.
As we age, our biological clocks wind down – but why? A Weizmann Institute team studying circadian clocks has found a clue: a link between the clocks and a group of metabolites called polyamines. When added to the drinking water of older mice, polyamines reversed some signs of aging; naturally found in many foods, it’s possible they could do the same for us.
Researchers have discovered a new cell type that appears to drive life-threatening food allergies and may help explain why some people get severe allergic reactions and others do not.
Whitehead Institute scientists have at last answered the long-standing question of how the growth-regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine—itself a key player in modulating muscle growth, appetite, and insulin secretion.
Scientists engineered stem cells to better understand the mechanisms behind a form of leukemia caused by changes in a key gene, according to a study led by Mount Sinai researchers and published online today in the journal Cell Reports.
The new technique allows scientists to study diseases like Alzheimer’s and Parkinson’s using cells from human patients
A team of Ludwig Cancer Research scientists has mapped out how a mutant version of the epidermal growth factor receptor (EGFR) known as EGFRvIII specifically drives critical processes that alter the reading of the genome to fuel the growth of the brain cancer glioblastoma multiforme (GBM) and—most important—how each process is linked to the other.
Working with gut stem cells from humans and mice, scientists from the Johns Hopkins Children's Center and the University of Pittsburgh have successfully grown healthy intestine atop a 3-D scaffold made of a substance used in surgical sutures.
Researchers have a new genome screen that has identified partner molecules of cell-waste disposal proteins. They applied their new method to identify other clock partners that target a multipurpose cell nucleus receptor for disposal.
When rats modeled with stroke were transplanted with newly discovered and unique Muse cells, neuronal regeneration resulted in significant improvements in neurological and motor functions and did not cause cancer, as other cells often do.
Scientists from Tulane University are using Argonne's Mira supercomputer to advance next-generation solar energy technologies by probing the functional interfaces found in organic and hybrid solar cells. Argonne Leadership Computing Facility staff helped accelerate their research by enhancing the team’s code so simulations run up to 30 percent faster on the supercomputer.
E. coli ClpB is a bacterial enzyme that untangles proteins. Such tangles are hallmarks of neurodegenerative diseases like Parkinson’s and Alzheimer’s. A study led by UAB's Aaron Lucius offers new insight on this amazing molecular machine, and could lead toward new treatment approaches.
Tick tock. Tick tock. A team of scientists from Duke-NUS Graduate Medical School Singapore (Duke-NUS) and the University of Michigan at Ann Arbor have discovered a molecular switch that regulates the body’s circadian clock and allows it to keep time. This switch could be a potential drug target to treat circadian rhythm disorders caused by jet lag, shift work or metabolic disorders.
An experimental drug originally identified in a National Cancer Institute library of chemical compounds as a potential therapy for brain and basal cell cancers improves the symptoms of mice with a form of the debilitating neurological disorder multiple sclerosis (MS), according to new research from NYU Langone Medical Center.
A team of Virginia Tech researchers has refined a mathematical model that simulates the impact of genetic mutations on cell division -- a step that could provide insight into errors that produce and sustain harmful cells, such as those found in tumors.
New York University biologists, in collaboration with scientists at the Stowers Institute for Medical Research, have identified a mechanism that promotes activation of genes critical for the initiation of embryonic development.
Researchers at Johns Hopkins and the University of Washington report new research that sheds light on how the retina sets its own biological rhythm using a novel light-sensitive pigment, called neuropsin, found in nerve cells at the back of the eye.
Fat grafting—taking fat from one area of the body and transferring it elsewhere—has become a widely used plastic surgery technique. But what's the best method of processing cells for fat grafting procedures? Available research data still can't settle that long-running debate, according to a review in the October issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Researchers have discovered how a tiny viral protein enables the infection of a complex plant, and the finding could lead to understanding viral diseases in other plants, animals and humans, according to a team of Texas A&M AgriLife Research biochemists.
UCSF researchers have engineered a molecular “on switch” that allows tight control over the actions of T cells, immune system cells that have shown great potential as therapies for cancer.
Mitochondria are not only the power plants of our cells; these tiny structures also play a central role in our physiology. By enabling flexible responses to new environments, mitochondria have helped humans adapt and evolve.
St. Jude Children’s Research Hospital scientists identify a mechanism that plays a key role in cellular organization and function and also offers a possible new treatment strategy for ALS and other degenerative disorders
Researchers at UCSF have succeeded in mapping the genetic signature of a unique group of stem cells in the human brain that seem to generate most of the neurons in our massive cerebral cortex.
Whitehead Institute researchers have developed a tool that allows scientists to monitor changes in DNA methylation over time in individual cells. Certain diseases, including cancer, cause changes in DNA methylation patterns, and the ability to document these alterations could aid in the development of novel therapies.
A team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has become the first to use a tissue-clearing technique to localize a rare stem cell population, in the process cracking open a black box containing detailed information about where blood-forming stem cells are located and how they are maintained.
UT Southwestern physiologists trying to understand the genetic code have found a previously unknown code that helps explain which protein should be created to form a particular type of cell.
UCSF researchers have successfully isolated human muscle stem cells and shown that the cells could robustly replicate and repair damaged muscles when grafted onto an injured site.
A new study from The Scripps Research Institute has shown that a specific molecule controls morphine receptor signaling in a small group of brain cells. The findings could lead to a new drug target for developing less-addictive pain medications.
An international team of researchers, led by scientists at the National University of Singapore, has identified a protein that regulates the growth of neurons by transporting key metabolic enzymes to the tips of neural cells. Their findings open up new avenues for design of drugs for ataxia, a motor coordination disorder.
University at Buffalo researchers and their colleagues at other institutions are publishing a paper online in Nature Communications on Sept. 18 about a new method they developed to more precisely capture how brain cells interact.
Drawing on complementary strengths of two San Diego institutions, The Scripps Research Institute and the University of California, San Diego have formed a new consortium with a big mission: to map cells in space and time.
Researchers have silenced genes within human cells to induce immunity to the parasite E. histolytica, demonstrating the effectiveness of a new approach to protecting people from infectious diseases.
Using an X-ray laser at the Department of Energy's SLAC National Accelerator Laboratory, researchers have for the first time directly seen myoglobin move within quadrillionths of a second after a bond breaks and the protein releases a gas molecule. The Linac Coherent Light Source X-ray laser is a DOE Office of Science User Facility, and its short, bright pulses were essential for observing these ultrafast, atomic-scale motions.
New research on sickle cell disease (SCD) has found that using antibiotics to deplete the body’s microbiome may prevent acute sickle cell crisis and could offer the first effective strategy for warding off the disease’s long-term complications, such as organ failure. The study, conducted by scientists at Albert Einstein College of Medicine and Montefiore Health System, could also lead to better treatment for other inflammatory blood-vessel disorders including septic shock. The findings were published online today in Nature.
Knocking out one or both crucial regulatory genes caused cleft lip, skin barrier defects, and a host of other developmental problems in mice, hinting that abnormalities in these molecular pathways could underlie many birth defects that are presently not well understood.
New research from the University of Washington's Friday Harbor Laboratories shows that a more acidic ocean can weaken the protective shell of a delicate alga. The findings, published Sept. 9 in the journal Biology Letters, come at a time when global climate change may increase ocean acidification.
Researchers have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging.
A team of researchers from the Stowers Institute for Medical Research and the University of Colorado Boulder has devised a novel optical technique — a combination of structured illumination microscopy (SIM) and single-particle averaging (SPA) — to resolve individual components of SPB duplication in living yeast cells.
A new role for the placenta has been revealed by University of Manchester scientists who have identified sites which store, and gradually release, oxygen for newly formed embryos in the weeks after the baby’s heart is developed.
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