In a potential game changer for the treatment of superbugs, a new class of antibiotics was developed that cured mice infected with bacteria deemed nearly “untreatable” in humans — and resistance to the drug was virtually undetectable.
Two classes of drugs prescribed off-label for some patients with Type 1 diabetes can provide significant benefits but also come with health concerns, according to a study by UT Southwestern Medical Center researchers. The findings are published in The Journal of Clinical Endocrinology & Metabolism.
UC San Diego researchers report that a late-stage, pre-clinical small molecule inhibitor reverses malignant hyper-editing by a protein that promotes silencing of the immune response, metastasis and therapeutic resistance in 20 different cancer types.
People afflicted with autoimmune diseases may someday receive help through treatments now under development by a Lawrence Livermore National Laboratory (LLNL) licensee and its’ collaborations with two major pharmaceutical companies.
An approved drug for chronic constipation also relieves the pain associated with that condition. New research demonstrates that the drug’s two actions can be separated biologically — a finding that may offer ways to precisely target visceral organ pain syndromes beyond constipation.
A team of researchers has developed a new method to screen FDA-approved drugs to determine if they could be repurposed or improved to help patients with a rare, debilitating disease of the nervous system.
The SLAS Discovery Editor's Top 10 annually showcases ten individual articles that stand out as the most innovative scientific achievements published in SLAS Discovery in the past 12 months.
Community awareness is critical to preventing overdoses
People with diabetes are twice as likely to develop dementia as those without the disease. In a new study, people with newly diagnosed type 2 diabetes who took the diabetes drug pioglitazone were less likely to later develop dementia than those who did not take the drug. The study is published in the February 15, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
By tapping into a cellular garbage disposal function, researchers found they could eliminate STAT5 from cell cultures and mice, setting the stage for potential development as a cancer treatment.
In a letter to the U.S. Food and Drug Administration (FDA), the American Society of Anesthesiologists (ASA) expressed its strong support of naloxone nasal spray products for non-prescription use. Naloxone, a safe life-saving medication that rapidly reverses an opioid overdose and significantly reduces the incidence of opioid overdose deaths, should be available to all patients across the United States as a nonprescription treatment, according to the ASA.
Researchers from Johns Hopkins Medicine and several other institutions say they have developed a quick clinical test that predicts which people with neck pain are more likely to benefit from epidural steroid injections, which deliver drugs directly around the spinal nerves to stop nerve inflammation and reduce pain.
Naloxone is an opioid receptor antagonist that rapidly reverses or blocks the effects of opioids, restores normal respiration and heart rhythm, and reverses the potentially fatal effects of an overdose. Although naloxone is included in U.S. CDC recommendations, the drug is currently prescribed to less than 1 in 70 patients prescribed high-dose opioid prescriptions. Researchers propose a call to action for all health providers and state medical societies to ensure the widest distribution and easy availability of naloxone, including over the counter, which is likely to be FDA-approved very soon.
The drug lasmiditan, which is used to treat migraines, shows promise as a possible treatment for acute kidney injury, according to a new study from the University of Arizona.
MD Anderson and Xilis announced a strategic collaboration to deploy Xilis' proprietary MicroOrganoSphere technology in support of preclinical research to accelerate the development of novel cancer therapies.
Virginia Tech professor Robert Gourdie says teamwork is an important element in the process of discovery, and it involves many teams full of talented, curious, and lively people.
Financial Strategies Acquisition Corp. (Nasdaq: FXCO) ("FXCO")(the "Company")., a Special Purpose Acquisition Company led by CEO Alexander V. Schinzing, today announced the execution of a definitive business combination agreement with Austin Biosciences Corp. ("Austin Biosciences").
Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the structure of messenger RNA (mRNA) based medicines.
Contrary to some common claims, a study led by Johns Hopkins Medicine researchers found that relatively high doses of cannabidiol (CBD) may increase the adverse effects of delta-9-tetrahydrocannabinol (THC), the main active ingredient in cannabis that can cause a mood alteration or a “high” sensation. The findings show that in edible cannabis products, CBD inhibits the metabolism, or breakdown, of THC, which may result in stronger and longer drug effects.
Nirmatrelvir–ritonavir (Paxlovid) significantly reduced the likelihood of hospitalization or death from COVID-19 in people at risk of severe illness, according to new research in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221608.
A study in mice, led by Tufts University School of Medicine scientists, found chronic stress reduced an animal’s abilities to produce and respond to neurosteroids, specifically allopregnanolone.
A new drug company founded by entrepreneur Mark Cuban could save patients $1.29 billion a year based on 2020 Medicare Part D expenditures on just the nine most popular urological drugs, according to a study published in the Journal of Urology.
Since 2017, the lab of Rahima Benhabbour, PhD, MSc, associate professor in the UNC/NCSU Joint Department of Biomedical Engineering, has been working with a research team at the Centers for Disease Control and Prevention (CDC) and others at UNC to develop an injectable implant that can release HIV pre-exposure prophylaxis (PrEP) medications into the body for a long period of time. Their latest research, published in Nature Communications, shows that the team’s latest formulation can provide up to six months of full protection.
Notalgia paresthetica is a common and underdiagnosed condition characterized by a persistent itch in the upper back. To date, there are no FDA-approved treatments specifically targeting this disorder. But a new study, published in the NEJM, suggests that patients with the disorder could potentially get relief with oral difelikefalin.
An estimated one in six older adults in the United States who take multiple prescription drugs risk major drug-drug interactions and other adverse drug effects that can worsen their medical conditions, increase the likelihood of cognitive impairment and falls, and lead to hospitalization or death.
Spike proteins are one of the main targets for COVID-19 vaccines and treatments. But those remedies gradually lose effectiveness when the spike proteins mutate. Now, researchers report in ACS Central Science that they have discovered small molecules that target other segments that mutate less.
UC Davis Comprehensive Cancer Center researchers are part of a large-scale research study to test a new drug therapy to treat pancreatic cancer.
The immunosuppressive drug methotrexate (MTX) can be linked to an elevated risk of three types of skin cancer, a new study by University of Gothenburg researchers shows.
A synthetic biosensor that mimics properties found in cell membranes and provides an electronic readout of activity could lead to a better understanding of cell biology, development of new drugs, and the creation of sensory organs on a chip capable of detecting chemicals, similar to how noses and tongues work.
Acute myeloid leukemia (AML) is an aggressive form of cancer that originates in the bone marrow, rapidly spreads to the blood and can quickly cause death if not treated promptly. Despite recent therapeutic advances, it continues to be associated with poor outcomes in the majority of patients with this disease.
The Society for Laboratory Automation and Screening (SLAS) invites members of the press, science journalists and trade press to attend the SLAS2023 International Conference and Exhibition, the society’s annual flagship conference.
A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health found that the share of promotional spending allocated to consumer advertising was on average 14.3 percentage points higher for drugs with low added benefit compared to drugs with high added benefit.
Taking vitamin D supplements does not reduce the risk of asthma attacks in children or adults, according to an updated Cochrane review.
According to an international group of researchers including a team from the University of Liverpool, patients experience 30% fewer side effects when medication doses are tailored to their DNA.
Few studies have evaluated the waning of vaccine effectiveness against severe outcomes caused by SARS-CoV-2 Omicron infection. Hong Kong is providing inactivated and mRNA vaccines, but the population had limited protection from natural infections before the Omicron variant emerged.
Researchers at Moffitt Cancer Center are investigating new treatment approaches for this patient population. In a new article published in the International Journal of Radiation Oncology, Biology and Physics, our team of physicians, led by Daniel Oliver, M.D., and Stephen Rosenberg, M.D., shows that stereotactic body radiotherapy, or SBRT, is an effective treatment for patients with early stage lung neuroendocrine tumors.
Papers on the use of AI in physiologically based pharmacokinetic modeling, how mild allergic airway responses may increase cardiovascular risk, and how single-cell transcriptomes can show dose-dependent disruption of hepatic zonation by TCDD are featured in lastest issue of Toxicological Sciences.
Pharmaceutical synthesis is often quite complex; simplifications are needed to speed up the initial phase of drug development and lower the cost of generic production.
New research has found some antidepressants may be effective in treating certain chronic pain conditions, but others lack convincing evidence on their effectiveness.
A UCLA-led study provides the first scientific evidence that brick and mortar pharmacies in Northern Mexican tourist towns are selling counterfeit pills containing fentanyl, heroin, and methamphetamine. These pills are sold mainly to US tourists, and are often passed off as controlled substances such as Oxycodone, Percocet, and Adderall.
The FDA cleared SCINTIX biology-guided radiotherapy to treat patients with lung and bone tumors. These tumors may arise from primary cancers or from metastatic lesions spread from other cancers in the body. The breakthrough nature of SCINTIX technology lies in its ability to detect and then treat multiple moving tumors.
Despite concerns over antimicrobial resistance, global antimicrobial use in animals could increase by 8% by 2030.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Kevin Garey, professor of pharmacy practice and translational research at the University of Houston College of Pharmacy is reporting the first well-controlled study to demonstrate that a microbiome therapeutic, SER-109, is associated with significant quality of life improvement in patients with the debilitating recurrent infection and disease caused by Clostridium difficile (or C. diff).
Below are some of the latest articles that have been added to the Surgery and the Transplantation channels on Newswise, a free source for journalists.
Reductions in violence are seen in individuals using Beta adrenergic-blocking agents (β-blockers) compared with periods that they are not taking the medication, in a study published January 31st in the open access journal PLOS Medicine. If the findings are confirmed by other studies, β-blockers could be considered as a way to manage aggression and hostility in individuals with psychiatric conditions.
A new survey finds that men who would be potential users of HIV pre-exposure prophylaxis (PrEP) medication prefer long-acting injections over pills, but rank side effects and costs as the most important issues for them in considering whether to take PrEP.
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