Mild cases of coronavirus disease 2019 (COVID-19) can trigger robust memory T cell responses, even in the absence of detectable virus-specific antibody responses, researchers report August 14 in the journal Cell.
Researchers at Washington University School of Medicine in St. Louis have created a COVID-19 vaccine candidate from a replicating virus. This experimental vaccine has proven effective at preventing pneumonia in mice.
In a mouse study, researchers at Washington University School of Medicine in St. Louis have found that an antibody that targets the protein TREM2 empowers tumor-destroying immune cells and improves the effectiveness of cancer immunotherapy.
This research shows that both Pseudomonas and Burkholderia use toxic weaponry, called Type VI Secretion Systems (T6SS), to compete with and establish dominance over each other. It could be possible to target or mimic this weaponry to defeat the bacteria before they cause irreparable lung damage.
Wistar scientists may have discovered a new way of identifying and targeting hidden HIV viral reservoirs during treatment with antiretroviral therapy (ART).
Researchers at UC San Diego School of Medicine report successfully implanting specialized grafts of neural stem cells directly into spinal cord injuries in mice, then documenting how the grafts grew and filled the injury sites, mimicking the animals’ existing neuronal network.
Scientists at Huntsman Cancer Institute at the University of Utah report today the development of new models to study molecular characteristics of tumors of the lung and pancreas that are driven by mutations in a gene named NTRK1. The findings were published today in the journal Cell Reports.
Researchers studying the mystery of why some weightlifters’ muscles grow much more quickly than others’ have found new answers through a novel experiment in which subjects worked out one leg and immobilized the other.
A new UChicago study describes inter- and intra-species diversity within the Lachnospiraceae bacteria family.
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases — creating more of themselves and producing mature airway cells — to regenerate lung tissue after an injury.
An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell.
In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease. The research is the latest example of a decoy strategy researchers at Rensselear Polytechnic Institute are developing against viruses like the novel coronavirus that spawned the current global health crisis.
Scientists at Washington University School of Medicine in St. Louis have created a virus that infects cells and interacts with antibodies just like the COVID-19 virus, but lacks the ability to cause severe disease. This safer virus makes it possible for scientists who do not have access to high-level biosafety facilities to join the effort to find drugs or vaccines for COVID-19.
Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer.
Women who do not need pain relief during childbirth may be carriers of a key genetic variant that acts a natural epidural, say scientists at the University of Cambridge.
Two daily fasting diets, also known as time-restricted feeding diets, are effective for weight loss, according to a new study. The study reported results from a clinical trial that compared a 4-hour time-restricted feeding diet and a 6-hour time-restricted feeding diet to a control group.
The work is the culmination of a U.S. Department of Energy project that began in 2014 with $3.3 million in funding and involved years of prototype development at Tulane and field testing in San Diego.
UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre- inflammatory bowel disease. This combination shuts down the mitochondria in cells of the colon lining, leading to gut inflammation. Mesalazine can help restart the mitochondria and treat pre-IBD condition.
Scientists combined solar cell technology with a novel optimization approach to develop a smart window prototype that maximizes design across a wide range of criteria.
A new study from Washington University School of Medicine in St. Louis has found that mice infected with Chikungunya virus get less sick and are less likely to transmit the virus to mosquitoes if they have healthy gut microbiomes.
The individual mix of microorganisms in the human gastrointestinal tract provides vital clues as to how any future incidence of type 2 diabetes can be predicted, prevented and treated.
A new study from Penn Medicine lends further evidence that the social behaviors tied to autism spectrum disorders (ASD) emerge from abnormal function of sensory neurons outside the brain.
New UCLA research conducted in mice could explain why some people suffer more extensive scarring than others after a heart attack. The study, published in the journal Cell, reveals that a protein known as type 5 collagen plays a critical role in regulating the size of scar tissue in the heart.
Research out today in the journal Cell shows that a specific change in the SARS-CoV-2 coronavirus virus genome, previously associated with increased viral transmission and the spread of COVID-19, is more infectious in cell culture.
By mapping molecular changes in the genome over time, UC San Diego researchers developed a formula to more accurately compare dog age to human age — a tool that could also help them evaluate how well anti-aging products work.
A new study shows that SARS-CoV-2, the virus that causes COVID-19 (coronavirus), can infect heart cells in a lab dish, indicating it may be possible for heart cells in COVID-19 patients to be directly infected by the virus. The discovery, published today in the journal Cell Reports Medicine, was made using heart muscle cells that were produced by stem cell technology.
UC San Diego School of Medicine researchers report that stool microbiomes of NAFLD patients are distinct enough to potentially be used to accurately predict which persons with NAFLD are at greatest risk for having cirrhosis.
After a brain injury, cells that normally nourish nerves may actually kill them instead, a new study in rodents finds. This “reactive” phenomenon may be the driving factor behind neurodegenerative diseases like glaucoma, a leading cause of blindness.
Like a scene out of “Invasion of the Body Snatchers,” a virus infects a host and converts it into a factory for making more copies of itself.
A new analysis of difficult-to-access genetic variation is the most comprehensive ever conducted in plants. It could guide the improvement of tomatoes and other crops.
When Pulitzer Prize and Grammy award winner Kendrick Lamar rapped “I got millions, I got riches buildin’ in my DNA,” he almost certainly wasn’t talking about the humble tomato. But a new study unveiling more than 230,000 DNA differences across 100 tomato varieties which will allow breeders and scientists to engineer larger, juicier, more profitable plants, proves that tomatoes indeed have riches buildin’ in their DNA, too.
A new study describes how poor oral health may worsen gut inflammation.
Weizmann Institute scientists and colleagues - including at the Max Planck Institute for Psychiatry - studied mice in a semi-natural setting and found that the hormone oxytocin can amplify aggression as well as friendliness.
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells — a type of immune cell — with measurably stronger activity against a form of leukemia, both in vivo and in vitro.
Researchers at Washington University School of Medicine in St. Louis have developed a mouse model of COVID-19 that is expected to speed up the search for drugs and vaccines for the potentially deadly disease.
Yale Cancer Center scientists have developed a new cell screening method for agents that alter biologic functions. This approach uses thousands of artificial proteins called “traptamers” and may help to answer research questions that are difficult to address with other cell screening methods, including the SARS-CoV-2 virus, COVID-19. The data is published today in the journal Cell Reports.
DALLAS – June 9, 2020 – Serotonin, a chemical known for its role in producing feelings of well-being and happiness in the brain, can reduce the ability of some intestinal pathogens to cause deadly infections, new research by UT Southwestern scientists suggests. The findings, publishing online today in Cell Host & Microbe, could offer a new way to fight infections for which few truly effective treatments currently exist.
Cancer researchers at Children’s Hospital of Philadelphia (CHOP) have harnessed tools used for the development of cancer immunotherapies and adapted them to identify regions of the SARS-CoV-2 virus to target with a vaccine, employing the same approach used to elicit an immune response against cancer cells to stimulate an immune response against the virus. Using this strategy, the researchers believe a resulting vaccine would provide protection across the human population and drive a long-term immune response.
A research group from the Institute of Molecular Embryology and Genetics (IMEG) at Kumamoto University, Japan has discovered that the gene C19ORF57 plays a critical role in meiosis.
A new study finds in sleep-deprived fruit flies, premature death is always preceded by the accumulation of reactive oxidative species in the gut. Antioxidant compounds that neutralize ROS allow sleep-deprived flies to have normal lifespans.
The collection of more than 25,000 fragments of ancient manuscripts known as the Dead Sea Scrolls include, among other ancient texts, the oldest copies of books of the Hebrew Bible. But finding a way to piece them all together in order to understand their meaning has remained an incredibly difficult puzzle, especially given that most pieces weren't excavated in an orderly fashion.
Researchers at Mount Sinai have discovered that human acute myeloid leukemia (AML) stem cells are dependent on a transcription factor known as RUNX1, potentially providing a new therapeutic target to achieve lasting remissions or even cures for a disease in which medical advances have been limited.
UNC-Chapel Hill researchers show how SARS-CoV-2 infects the nasal cavity to a great degree, and progressively less so lower down the respiratory tract, suggesting the virus tends to become firmly established first in the nasal cavity, but can be aspirated into the lungs to cause serious disease.
A Ludwig Cancer Research study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin.
Different "Canaanite" people from the Bronze Age Southern Levant not only culturally, but also genetically resemble each other more than other populations. A team around Ron Pinhasi from the Department of Evolutionary Anthropology found in a recent study that their DNA is a mixture of two populations: The Chalcolithic Zagros and Early Bronze Age Caucasus. The results have been published in "Cell".
Secrets to cementing the sustainability of our future infrastructure may come from nature, such as proteins that keep plants and animals from freezing in extremely cold conditions. CU Boulder researchers have discovered that a synthetic molecule based on natural antifreeze proteins minimizes freeze-thaw damage and increases the strength and durability of concrete, improving the longevity of new infrastructure and decreasing carbon emissions over its lifetime.
In this study, researchers investigated if specific targeting of CD133+ glioblastoma with cutting-edge immunotherapy drugs could eradicate the most aggressive subpopulation of cells in the tumour. They also looked at the safety of CD133-targeting therapies on normal, non-cancerous human stem cells including hematopoietic stem cells which create blood cells and progenitor cells which can form one or more kinds of cells.
Beneficial strains of bacteria residing in our guts, genital tracts, and skin have been shown to play a role in human health, and now, researchers publishing May 26 in the journal Cell Reports suggest that some of these "good" bacteria also have a niche in our noses
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