Curated News: Cell (journal)

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Scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a previously unknown way that stress hormones (glucocorticoids) control genes in the liver to help the body adapt to the fasting state. The study, published today in Cell Metabolism, describes an obscure protein, SETDB2, that’s increased during times of fasting and alters the genome to help turn on genes needed to adjust to the absence of food.

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Biomedical investigators at Cedars-Sinai have identified an enzyme found in all human cells that alerts the body to invading bacteria and jump-starts the immune system. In their study, published in the peer-reviewed medical journal Cell, the investigators provide clues to unraveling some of the mysteries surrounding the human immune system, which defends the body against harmful microbes such as bacteria.

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Research from investigators at Rutgers Cancer Institute of New Jersey; University of California, Los Angeles; University of California, Santa Cruz and other institutions shows a computational approach examining abnormal “signaling” in clinical prostate cancer tissues that is responsible for their spread and resistance to treatment and can help identify patient subsets for targeted therapies.

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To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in. A research group at the University of Basel now describes for the first time a mechanism by which hippocampal neural stem cells regulate their own cell fate via the protein Drosha. The journal Cell Stem Cell has published their results.

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New research from the laboratory of Zachary T. Schafer, associate professor in the Department of Biological Sciences at the University of Notre Dame, could lead to new therapies to treat patients who suffer from metastatic disease.

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Nobel laureate and University of Colorado Cancer Center investigator, Thomas Cech, PhD, uses CRISPR gene editing technology and live cell, single molecule microscopy to watch in real-time, for the first time, the essential interaction between telomerase and telomeres.

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Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today’s most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a mortality rate of 30-50% and cause an estimated 1.5 million deaths worldwide annually.

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Study maps out abnormal signaling pathways in prostate cancer cells and provides computational approaches to identify individualized targets for therapy

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The botulinum toxins are among the deadliest substances on Earth, and two specific toxins — including the popular drug Botox — have multiple uses for treating many neuromuscular conditions, including frown lines, disabling muscle spasms and migraine headaches.

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Duke Health-led researchers have discovered new information about the signaling mechanism of cells that could one day help guide development of more specific drug therapies.

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UT Southwestern Medical Center researchers have identified a new way to target lung cancer through the KRAS gene, one of the most commonly mutated genes in human cancer and one researchers have so far had difficulty targeting successfully.

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New research by University of Iowa scientists helps explain how a hormone system often targeted to treat cardiovascular disease can also lower metabolism and promote obesity.

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Scientists at Washington University School of Medicine in St. Louis have identified antibodies capable of protecting against Zika virus infection, a significant step toward developing a vaccine, better diagnostic tests and possibly new antibody-based therapies.

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Prof. Fiona Doetsch's research team at the Biozentrum, University of Basel, has discovered that the choroid plexus, a largely ignored structure in the brain that produces the cerebrospinal fluid, is an important regulator of adult neural stem cells. The study recently published in "Cell Stem Cell" also shows that signals secreted by the choroid plexus dynamically change during aging which affects aged stem cell behavior.