In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson’s disease.
Analysis shows substantial differences in treatment, outcomes, and efficiency in heart attack care across six high-income countries despite well-established international guidelines U.S. heart attack death rate was among the highest, even with adherence to recommended treatments and faring well on other measures All countries excelled in some measures, but none excelled in all, even though well-established international guidelines are readily available
A new study in mice led by neuroscientists at UT Southwestern’s Peter O’Donnell Jr. Brain Institute shows that it’s not just calories that count.
Scientists at UC San Diego School of Medicine and Rady Children’s Institute of Genomic Medicine describe novel methods for inferring the movement of human brain cells during fetal development by studying healthy adult individuals who have recently passed away from natural causes.
To help address the rising tide of Alzheimer’s disease nationwide, researchers at Albert Einstein College of Medicine in collaboration with faculty at Pennsylvania State University and other institutions, have received a five-year, $32 million grant from the National Institutes of Health (NIH) to support the ongoing Einstein Aging Study (EAS), which focuses on both normal aging and the special challenges of Alzheimer’s disease, and other dementias. EAS was established at Einstein in 1980 and has been continuously funded by the NIH.
A test of protein in the blood gets further support as a biomarker for patients diagnosed with frontotemporal dementia (FTD), a group of brain disorders with few treatment options. These disorders are characterized by changes in behavior, cognition, language or movement.
The National Institutes of Health (NIH) and the National Institute on Aging recently approved funding for a 2022 study by the Institute for Exercise and Environmental Medicine (IEEM), where a research team will look into how body weight – even extra weight gain like the kind recently resulting from the COVID-19 pandemic – may adversely affect breathing in seniors.
Clinical awareness of connection between alcohol and dementia is paramount to providing the best patient care management
Funded through a $418,000 R21 grant from the National Institutes of Health’s National Institute on Aging, assistant professor Emily Cope, associate professor Greg Caporaso and professor Egbert Schwartz recently began working together on “Development of in vivo quantitative stable isotope probing to quantify microbiome dynamics in Alzheimer’s disease.”
The Dementia Care Study (D-CARE), a nation-wide clinical trial assessing the effectiveness of different approaches to caring for people with Alzheimer’s disease and other dementias, has reached its recruitment goal by enrolling 2,176 persons living with dementia and their caregivers
Tulane scientists will use the five-year grant to better understand why the brain-protecting benefits of estrogen may not apply to all women, especially those with hypertension and Type 2 diabetes.
A study led by UC Davis has found significant gut bacteria profile differences between Black and white women, even after accounting for their insulin sensitivity status.
For the first time, scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer’s disease treatment.
Older women are among the most susceptible to developing UTIs, an infection of the bladder and urethra that causes urinary urgency and pain. UTIs also can cause delirium in older people, resulting in a sharp decline in mental abilities that triggers disoriented thinking.
Researchers from Canisius College publish evidence that autism characteristics are associated with challenges in physical health, mental health and psychological well-being during later life
New research from Sanford Burnham Prebys has revealed features of the aging Down syndrome brain that could help explain why people with Down syndrome almost inevitably get Alzheimer's later in life.
20210305093594.png&width=400&height=400){kind=logo}
Studies suggest that exposure to the COVID-19 pandemic has been associated with a variety of different mental health consequences including reports of depression, loneliness, and insomnia. People who are more than 65 years of age and those with underlying medical conditions such as type 2 diabetes and obesity are particularly vulnerable to negative outcomes from COVID-19. Until now, few investigations have identified and separated the mental health consequences of exposure to the COVID-19 pandemic from preexisting factors in this age group. A new prospective study of a large cohort of older adults with type 2 diabetes and overweight/obesity from across the U.S. has explored this subject with surprising results.
Johns Hopkins has received a $20 million grant from the National Institute on Aging that will spur the development of artificial intelligence devices (AI) to improve the health of older adults and help them live independently for longer — a relatively untapped use of this technology.
The University of California, Irvine Center for Neural Circuit Mapping (CNCM) has been awarded three new grants: a four year, $4.8M grant from the National Institute on Aging; a three year, $1.8M grant from the Food and Drug Administration (FDA); and, a one year, $.5M grant from the National Institute of Mental Health. The grants will support the efforts of CNCM Investigators to develop powerful new molecular tools and will enhance resources offered by the Center to neurosciences researchers worldwide.
A study by UT Southwestern researchers finds that changing the biochemistry of parts of brain cells abolished the formation of amyloid beta plaques in a mouse model of Alzheimer’s disease. The finding, published in eLife, might eventually lead to treatments that prevent the memory-robbing condition in humans.
Washington University School of Medicine in St. Louis is joining the National Institutes of Health’s (NIH) new research network focused on the study of senescent cells, a rare and important population of cells that is difficult to study but vital for understanding aging and the diseases of aging, including cancer and neurodegeneration. The goal is to help researchers develop new therapies that target cellular senescence to prevent or treat such diseases and improve human health.
Add an improved memory to the list of the many benefits that accompany having a sense of purpose in life. A new study led by Florida State University researchers showed a link between an individual’s sense of purpose and their ability to recall vivid details.
Researchers at Washington University School of Medicine in St. Louis, Mayo Clinic in Rochester, Minn., and The Neuro (Montreal Neurological Institute-Hospital) of McGill University have received a five-year grant expected to total $35.1 million for an extension of a study designed to develop biomarkers that indicate which people with the sleep disorder will go on to develop neurodegenerative diseases.
People with rapid eye movement (REM) sleep behavior disorder act out their dreams. While sleeping safely in bed, for example, they might throw up their arms to catch an imaginary ball or try to run from an illusory assailant.
Vanderbilt University Medical Center has been awarded a five-year, $31.7 million grant by the National Institute on Aging, part of the National Institutes of Health (NIH), to harmonize research data gathered on human subjects in scores of disparate studies of Alzheimer’s disease and related dementias (ADRD).
In a study published in the September issue of the journal Communications Biology, UNLV neuroscientists show that chronic hyperglycemia impairs working memory performance and alters fundamental aspects of working memory networks.
Physicians prescribed opioids more often to their white patients who complained of new-onset low back pain than to their Black, Asian and Hispanic patients during the early days of the national opioid crisis, when prescriptions for these powerful painkillers were surging but their dangers were not fully apparent.
In a research letter in JAMA, physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) found that the vast majority of patients who had a diagnosis of either cognitive impairment, Alzheimer’s disease, or Alzheimer’s disease related disorders, including cardiovascular disease, prior stroke, use of blood thinners, and age over 85 years, would have been excluded them from the aducanumab clinical trials.
Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.
Have you ever met someone you instantly liked, or at other times, someone who you knew immediately that you did not want to be friends with, although you did not know why? Now, a new study from the University of Maryland School of Medicine (UMSOM) suggests that there may be a biological basis behind this instantaneous compatibility reaction.
Hackensack Meridian Hackensack University Medical Center, Center for Memory Loss and Brain Health will be participating in a multicenter clinical trial to study the safety and efficacy of escitalopram, an antidepressant, for the treatment of agitation related to Alzheimer’s disease. This study is sponsored by the National Institute on Aging. Johns Hopkins University is the principal site and Hackensack University Medical Center will begin enrolling patients in the study starting in September 2021.
A new study from the Perelman School of Medicine at the University of Pennsylvania shows how to overcome resistance to CAR T cell therapy with an experimental small molecule inhibitor.
Emergency department physicians who saw patients with a pulmonary embolism—a blood clot in the lung—were about 15% likelier over the next 10 days to test subsequent patients for the same thing.
A five-year, nearly $6 million grant from the National Institute on Aging will allow investigators with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics to use artificial intelligence (AI) to advance Alzheimer’s disease research.
Obesity is a major public health issue among Latinos, and a risk factor for Alzheimer’s disease. But in a new study, researchers at UC San Diego report that cardiometabolic abnormalities, such as hypertension, are more strongly associated with cognitive decline than obesity alone.
A recently published study co-authored by University of Kentucky Sanders-Brown Center on Aging researcher Justin Miller, Ph.D., identifies 11 rare candidate variants for Alzheimer’s disease. Researchers found 19 different families in Utah that suffered from Alzheimer’s disease more frequently than what is considered normal.
The role of peripheral and brain infections in the development of Alzheimer's disease is the focus of new research at The University of Texas Health Science Center at Houston (UTHealth), funded with a $2 million grant from the National Institutes of Health (NIH).
Risk of SARS-CoV-2 infection increased 30 percent for households with a recent birthday in counties with high rates of COVID-19 Findings suggest informal social gatherings such as birthday parties played role in infection spread at the height of the coronavirus pandemic No birthday-bash infection jumps seen in areas with low rates of COVID-19 Households with children’s birthdays had greater risk of SARS-CoV-2 infection than with adult birthdays
University of Kentucky Neuroscience Professor Greg Gerhardt's new research program will provide answers to long-standing questions about the role of neurotransmitters GABA and glutamate in the progression of Alzheimer’s disease. A culmination of his nearly 40 years of brain research, Gerhardt's study could help to develop new treatments for the disease.
News release about the follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management — lowering systolic blood pressure to less than 120 mm Hg -- dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering systolic blood pressure to less than 140 mm Hg.
Heart failure (HF) – when the heart can’t pump enough blood and oxygen through the body – affects approximately 6.2 million adults in the United States and is the primary cause of hospitalization in the elderly. Unfortunately, older adults with heart failure often have poor outcomes resulting in reduced quality of life, high mortality and frequent rehospitalizations.
Statins are prescribed to less than half of eligible U.S. patients, and a new study shows time of day may affect doctors’ likelihood of writing a script
Contrary to popular belief, a new study from the University of Chicago Medicine found the frequency of abdominal surgery in older adults is decreasing, especially among adults over the age of 85.
In the first clinical trial of nicotinamide mononucleotide (NMN), researchers at Washington University School of Medicine in St. Louis have found that the compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice also has clinically relevant effects in people.
One of the keys to having a healthy brain at any age is having a healthy blood-brain barrier, a complex interface of blood vessels that run through the brain. Research shows the blood-brain barrier leaks as we age, and we lose cells called pericytes. But could this leak and the difficulties in recall be the early stages of Alzheimer’s disease?
Nearly one-third of adults age 65 and older who take thyroid hormone also take medications that are known to interfere with thyroid function tests, according to a study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.
People over 65 shouldn’t take three or more medicines that act on their brain and nervous system, experts strongly warn, because the drugs can interact and raise the risk of everything from falls to overdoses to memory issues. But a new study finds that 1 in 7 people with dementia who live outside nursing homes are taking at least three of these drugs.
Physicians understand frailty as a dysregulation among multiple systems in the body that make it less resilient and unable to recover completely when faced with a physical challenge such as injury or illness. “Defining frailty on a scientific level, however, has been a challenging task,” explains Ravi Varadhan, Ph.D., associate professor of oncology in the Division of Biostatistics and Bioinformatics at the Johns Hopkins Kimmel Cancer Center.
There is now keen interest in deeper investigation of infectious agents as the trigger of Alzheimer's disease
Five genes may play a key part in influencing if a person will contract Lewy body dementia, and possibly dementia from Parkinson's and Alzheimer’s diseases, according to a study published in Nature Genetics Feb. 15. The genes, BIN1, TMEM175, SNCA, APOE, and GBA, were identified by a team of scientists at the National Institute of Neurological Disorders and Stroke and the National Institute on Aging, National Institutes of Health, and sequenced by The American Genome Center (TAGC), a series of state-of-the-art laboratories at the Uniformed Services University of the Health Sciences.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right
