Patients whose immune systems are weakened due to cancer, organ or bone marrow transplants, chronic diseases, or the medications used to treat these conditions may feel like they have enough on their plates without worrying about whether and when they should take an additional dose of COVID-19 vaccine and a flu shot.
Scientists at The Wistar Institute have identified two genes that play a critical role in protecting ovarian cancer from the immune system.
High levels of European ancestry are associated with an increase in type I interferon pathway activity in early infection
A new article published in The New England Journal of Medicine suggests that secondary antibodies known as “anti-idiotype antibodies” could be responsible for some of the side effects of COVID-19 vaccines and the symptoms of long-haul COVID.
In a collaborative study, Cleveland Clinic researchers sought to understand how COVID-19 infection affects pregnant mothers and their children. They published the results of their clinical study in Cell Reports Medicine.
Researchers discovered that antihistamines are associated with improved responses to immunotherapy. Their work revealed a role for the histamine receptor in suppressing T cell activation to block anti-tumor immune responses.
The population’s immunity to SARS-CoV-2, achieved either through infection or vaccination, is crucial to overcome the COVID-19 pandemic.
A vaccine booster is readied for use.
A group of scientists led by researchers from the RIKEN Center for Integrative Medical Sciences have discovered that B-cells, a type of immune cell, secrete the neurotransmitter GABA, and also found that the GABA secreted by the B-cells promoted the emergence of anti-inflammatory macrophages, blunting the body’s cytotoxic T-cell-based response to tumors.
About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds to these therapies—and for many, the relief is temporary.
People taking TNF inhibitors, a kind of immunosuppressive drug used to treat rheumatoid arthritis and other autoimmune conditions, produced a weaker and shorter-lived antibody response after two doses of Pfizer's COVID-19 vaccine, according to a study from Washington University School of Medicine in St. Louis. A third vaccine dose drove antibody levels back up, indicating that this additional dose may provide protection as the virus's delta variant continues to spread.
As widely-anticipated decisions about COVID-19 vaccine boosters roll out from U.S. agencies today, insights from an independent study underscore why boosters are important for all adults.
New research shows how genetic variations linked to severe cases of COVID-19 affect our immune cells. The study is one of the first in-depth look at the connections between COVID-19 severity and gene expression in many types of immune cells. This work could guide the development of new COVID-19 therapies to boost immune cell function.
To grow and spread, cancer cells must evade the immune system. Investigators from Brigham and Women’s Hospital and MIT used the power of nanotechnology to discover a new way that cancer can disarm its would-be cellular attackers by extending out nanoscale tentacles that can reach into an immune cell and pull out its powerpack.
The Perelman School of Medicine at the University of Pennsylvania will continue to be on the leading edge of autoimmune research and care with the launch of the Colton Center for Autoimmunity at Penn. The new center unites research and patient care programs across Penn to drive advances in autoimmune diagnosis, prognosis, and treatment.
Based on preliminary findings from their research into renal and breast cancer, biochemists Archana Varadaraj and Narendiran Rajasekaran were recently awarded $469,000 by the National Institutes of Health to apply those findings to a potential treatment for Idiopathic Pulmonary Fibrosis, a serious, irreversible lung disease affecting more than 100,000 Americans.
Research in mice demonstrates how diet alters a gut microbe molecule that, in turn, prompts immune cells to downregulate inflammation.
The study found that overall, hospitalized COVID-19 patients taking immunosuppressive drugs did not face increased risk of death or being put on a ventilator compared with non-immunosuppressed hospitalized COVID-19 patients.
New research from McMaster University, aimed at understanding the immune response to COVID-19 vaccines, found some long-term care residents no longer had high antibody levels months after their second dose, directly supporting government decisions to provide third doses.
A recent study by Johns Hopkins Medicine researchers provides evidence that CD4+ T lymphocytes produced by people who received either of the two available messenger RNA (mRNA) vaccines for COVID-19 persist six months after vaccination at only slightly reduced levels from two weeks after vaccination.
Most cancer patients who had no measurable immune response after being fully vaccinated for COVID-19 were helped by a third vaccine dose, according to a new study by investigators at the Montefiore Einstein Cancer Center (MECC). The findings, published online today in Cancer Cell, also show that a “booster” shot is extremely beneficial for all cancer patients, who face a heightened risk of severe disease and dying from COVID-19, and particularly in people who have a blood cancer.
If you got the COVID-19 shots back in early spring, your antibodies are likely waning. But it’s not something you need to be worried about, according to a new study from the University of Georgia.
A novel study — led by University of California San Diego and UCLA, in collaboration with the La Jolla Institute for Immunology — is assessing whether medicinal mushrooms and Chinese herbs provide therapeutic benefit in treating acute COVID-19 infection.
A new Wistar Institute study shows how key features on the surface of HIV-infected cells help the disease evade detection by the immune system.
A Q&A with a University of Florida Health allergist and immunologist
在家人齐聚共度节假日之际，免疫力低下的患者务必采取额外的措施，保护自己免于罹患COVID-19（2019 冠状病毒病），这一点很重要。免疫系统受损的人患上COVID-19重症的风险更高。这些人包括癌症患者、接受了移植手术并正在服用免疫抑制药物的患者，以及感染艾滋病毒/艾滋病的晚期和未接受过治疗的患者。
مدينة روتشستر، ولاية مينيسوتا- بينما تتجمع العائلات لقضاء العطلات، من المهم للمرضى الذين يعانون من نقص المناعة اتخاذ خطوات إضافية للمساعدة في حماية أنفسهم من فيروس كورونا المستجد (كوفيد-19). الأشخاص المصابون بضعف في جهاز المناعة عرضة بشكل أكبر لخطر المرض الشديد جرَّاء فيروس كورونا المستجد (كوفيد-19
Conforme as famílias se reúnem para as festas de final de ano, é importante que os pacientes imunocomprometidos tomem medidas extras para ajudar a se proteger da COVID-19. Pessoas com o sistema imunológico enfraquecido correm maior risco de adoecer gravemente com a COVID-19.
Dada la proximidad de las reuniones familiares para celebrar las festividades, es importante que los pacientes con compromiso inmunitario tomen medidas adicionales para protegerse contra la COVID-19.
New research suggests there may someday be a role for ibuprofen in providing older adults with lasting immunity against RSV, a virus commonly associated with infants and young kids that also rivals the flu as a dangerous wintertime infection for the elderly.
El alergista Mark Corbett, MD, de Louisville, KY, fue designado como presidente del Colegio Americano de Alergia, Asma e Inmunología (ACAAI) en la Reunión científica anual del ACAAI el 8 de noviembre en Nueva Orleans.
As families prepare to gather later this month for Thanksgiving, it is important for patients who are immunocompromised to take extra steps to protect themselves from becoming infected with COVID-19. People who are immunocompromised have weakened immune systems, which means they have a higher risk of becoming severely ill from COVID-19.
Johns Hopkins researchers identified two distinct clusters of patients with PN: those who had increased inflammation in the blood, and those who did not but were more likely to have a history of spinal disease, which may sensitize the nerves. Identifying those with unique types of inflammation may help doctors provide more precise and personalized treatment for the disorder.
Allergist Mark Corbett, MD, of Louisville, KY, was installed as president of the American College of Allergy, Asthma and Immunology at the ACAAI Annual Scientific Meeting on November 8 in New Orleans.
Université de Montréal chemists looked at lab samples of patients who recovered from a mild case of COVID-19 and found that those over 50 produced more antibodies against the SARS-CoV-2 virus.
• People who are on dialysis or who have undergone kidney transplantation have immune system–related differences compared with people with normal kidney function, and these differences are further amplified by SARS-CoV-2 infection. • The findings may help explain why these individuals face a higher risk of dying from COVID-19. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
Stress can have a significant negative effect on health, but our understanding of how stress impacts the development and progression of cancer is just beginning. A team from Roswell Park Comprehensive Cancer Center has identified an important mechanism by which chronic stress weakens immunity and promotes tumor growth. Their findings, just published in Cell Reports, point to the beta-adrenergic receptor (β-AR) as a driver of immune suppression and cancer growth in response to stress, opening the possibility of targeting this receptor in cancer therapy and prevention.
It’s common for people with psoriasis to develop dry, inflamed skin lesions. But researchers found specific gene expression changes in healthy-appearing skin were a better predictor of clinical response to etanercept, an anti-TNF treatment prescribed to up to one-fifth of psoriasis patients. They say finding predictive signs in a patient’s genetic profile is a step toward applying precision medicine to complex inflammatory skin diseases.
A new study being presented at this year’s ACAAI Annual Scientific Meeting followed 5,874 kids with asthma in Los Angeles for 15 years and found no increase in allergic sensitizations.
Un nuevo estudio que se presenta en la Reunión científica anual del ACAAI de este año mostró que la mayoría de las mujeres embarazadas con una etiqueta de alergia a la penicilina a las que se les hizo la prueba no eran alérgicas y podían tolerar la penicilina durante el parto.
Un nuevo caso médicamente difícil presentado en la Reunión Científica Anual del ACAAI de este año informa de una situación en la que un medicamento antinflamatorio no esteroideo (AINE) causó una reacción anafiláctica en una maratonista.
Un nuevo estudio que se presenta en la Reunión científica anual del ACAAI de este año revela que la incorporación temprana del huevo está asociada con una menor probabilidad de tener alergia al huevo.
Un nuevo estudio que se presenta en la Reunión científica anual del ACAAI de este año revela que la población latina con asma tenían 4.6 veces más probabilidad que la población negra de presentar exacerbaciones del asma (asma no controlada) después de la COVID-19 y 2.9 veces más probabilidad que la población blanca.
Un nuevo estudio que se presenta en la Reunión científica anual del ACAAI de este año revela que la mayoría de los adultos encuestados no recibió preparación suficiente para su transición de parte de sus proveedores de la salud de asma infantil.
Un nuevo estudio que se presenta en la Reunión científica anual del ACAAI de este año hizo un seguimiento de 5874 niños con asma en Los Ángeles durante 15 años y descubrió que no hubo un aumento de las sensibilizaciones alérgicas.
Dos nuevos estudios que se presentan en la Reunión científica anual del ACAAI de este año muestran que la mayoría de las personas que piensan que tendrán una reacción alérgica, o que creen que han tenido una respuesta alérgica a la primera vacuna, pueden recibir todas las dosis de la vacuna de forma segura.
Un nuevo estudio que se presenta en la Reunión científica anual del ACAAI de este año revela que, aunque el 58 % de los encuestados informaron de que su médico de atención primaria (PCP) les habló sobre la incorporación temprana del cacahuate, solo el 40 % de los padres dijo haber recibido una recomendación de incorporar el cacahuate antes de los 11 meses de edad.
A new study being presented at this year’s ACAAI Annual Scientific Meeting reveals Latinos with asthma were 4.6 times more likely than Blacks to develop asthma exacerbations (uncontrolled asthma) following COIVD-19, and 2.9 times more likely than whites.
A new study being presented at this year’s ACAAI Annual Scientific Meeting showed the majority of pregnant women with a penicillin allergy label who were tested were not allergic and could tolerate penicillin during labor.
A new study being presented at this year’s ACAAI Annual Scientific Meeting reveals that although 58% of those surveyed reported their primary care physician discussed early peanut introduction, only 40% of the parents said they received a recommendation to introduce peanut by 11 months of age.
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