Feature Channels: Biotech

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Released: 2-Jun-2022 12:00 PM EDT
Cultivated autologous limbal epithelial cells (CALEC): product development, manufacture, and initial evaluation of feasibility
Preprints

Ula Jurkunas, Jia Yin, Lynette Johns, Sanming Li, Helene Negre, Kit Shaw, Lassana Samarakoon, Allison Ayala, Ahmad Kheirkhah, Kishore Katikireddy, Alex Gauthier, Stephan Ong Tone, Stacey Ellender, Diego Hernandez Rodriguez, Heather Daley, Reza Dana, Jerome Ritz, Myriam Armant

Released: 2-Jun-2022 12:00 PM EDT
Genetic polymorphisms of rs12437118 in ESRRB locus associated with tuberculosis susceptibility in a Chinese Han population
Preprints

Wei Wang, Lingjuan Zhao, Yong Sun, Weicong Ren, Xuxia Zhang, Chuanyou Li, Mengqiu Gao

Released: 2-Jun-2022 12:00 PM EDT
Maternal Dendritic Cells Influence Fetal Allograft Response following Murine In-Utero Hematopoietic Stem Cell Transplantation
Preprints

Karthikeyan Kandasamy, Nuryanti Binti Johana, Lay Geok Tan, Yvonne Tan, Julie Yeo Su Li, Li Zhihui, Koh Jiayu, Florent Ginhoux, Jerry Ky Chan, Mahesh A Choolani, Citra Nz Mattar

Newswise: A World First: For the First Time, a Human Liver Was Treated in a Machine and Then Successfully Transplanted
Released: 1-Jun-2022 1:05 AM EDT
A World First: For the First Time, a Human Liver Was Treated in a Machine and Then Successfully Transplanted
University of Zurich

The Liver4Life research team owes its perfusion machine, which was developed in house, to the fact that it became possible to implant a human organ into a patient after a storage period of three days outside a body.

Newswise: New Artificial Enzyme Breaks Down Tough, Woody Lignin
26-May-2022 1:20 PM EDT
New Artificial Enzyme Breaks Down Tough, Woody Lignin
Pacific Northwest National Laboratory

An innovative artificial enzyme has shown it can chew through woody lignin, an abundant carbon-based substance that stores tremendous potential for renewable energy and materials.

Released: 27-May-2022 12:00 AM EDT
Spinal Fusion Properties of Mechanically-Reinforced, Osteomodulatory Chitosan Hydrogels
Preprints

Blake T Darkow, Joseph P Herbert, Mark J Messler, Abigail Grisolano, August J Hemmerla, Austin D Kimes, Julien Lanza, Yisheng Sun, Julia R Crim, Derek Stensby, Caixia Wan, Don K Moore, Bret D Ulery

Released: 27-May-2022 12:00 AM EDT
A network of CLAVATA receptors buffers auxin-dependent meristem maintenance
Preprints

Amala John, Elizabeth Sarkel Smith, Daniel S Jones, Cara Soyars, Zachary L. Nimchuk

Released: 27-May-2022 12:00 AM EDT
Amsacrine combined with etoposide and methylprednisolone is a feasible and safe component in first-line intensified treatment of pediatric patients with high-risk acute lymphoblastic leukemia in CoALL-08-09 trial
Preprints

Gabi Escherich, Kerstin Mezger, Sabine Ebert, Hannah Muhle, Udo Zur Stadt, Arndt Borkhardt, Dagmar Dilloo, Jörg Faber, Tobias Feuchtinger, Thomas Imschweiler, Norbert Jorch, Arnulf Pekrun, Irene Schmid, Franziska Schramm, Martin Zimmermann, Martin Horstmann

Released: 27-May-2022 12:00 AM EDT
Basal Forebrain Cholinergic Circuits Orchestrate Diverse Cell Types in the Adult Dentate Gyrus to Support Neural Stem Cell Function and Spatial Memory
Preprints

Luis Quintanilla, Juan Song, Jeremy Simon, Ya-Dong Li, Brent Asrican, Seth Tart, Yan-Jia Luo, Yijing Su, Hongjun Song, Ryan N. Sheehy, Guo-Li Ming

Released: 27-May-2022 12:00 AM EDT
CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage.
Preprints

Dongshu Liu, Suhe Dong, Cong Liu, Jicong Du, SiNian Wang, Huijie Yu, Wei Li, Zhongmin Chen, Renjun Peng, Qisheng Jiang, Mengying Zou, Fengsheng Li, Rong Zhang

Released: 27-May-2022 12:00 AM EDT
Stability and Biosafety of human epidermal stem cell for wound repair: Preclinical evaluation
Preprints

Xiaohong Zhao, Xue Li, Ying Wang, Yicheng Guo, Yong Huang, Dalun Lv, Mingxing Lei, Shicang Yu, Gaoxing Luo, Rixing Zhan

Released: 27-May-2022 12:00 AM EDT
Infant Mesenchymal Stem Cell Insulin Action Is Associated with Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study
Preprints

Alec B Chaves, Donghai Zheng, Jonathan A Johnson, Bryan C Bergman, Zachary W Patinkin, Vincent Zaegel, Ericka M Biagioni, Polina Krassovskaia, Nicholas T Broskey, Linda E May, Dana Dabelea, Joseph A Houmard, Kristen E Boyle

Released: 27-May-2022 12:00 AM EDT
Prognostic Signature: Papillary Thyroid Carcinoma With Poor Prognosis Has Enhanced Immune Escape Capacity And High Tumor Heterogeneity
Preprints

Xinyang Li, Zhenyu Xie, Yinde Huang, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Wenbin Chen, Yuchen He, Jian Zhang

Newswise: Diabetes Drug Improves Antibacterial Treatment Speed and Effectiveness, Researchers Report
Released: 26-May-2022 2:05 PM EDT
Diabetes Drug Improves Antibacterial Treatment Speed and Effectiveness, Researchers Report
Tsinghua University Press

Old dogs may not learn new tricks, but old drugs can, according to a research team based in China.

Released: 26-May-2022 12:00 PM EDT
Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration
World Journal of Stem Cells

Poor healing of cutaneous wounds is a common medical problem in the field of traumatology. Due to the intricate pathophysiological processes of wound healing, the use of conventional treatment methods, such as chemical molecule drugs and tradit

Released: 26-May-2022 12:00 PM EDT
Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats
World Journal of Stem Cells

BACKGROUNDDiabetes mellitus (DM) is a serious and growing global health burden. It is estimated that 80% of diabetic patients have micturition problems such as poor emptying, urinary incontinence, urgency, and urgency incontinence. Patients wit

Released: 26-May-2022 12:00 PM EDT
Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology
World Journal of Stem Cells

BACKGROUNDHuman Wharton’s jelly-derived mesenchymal stromal/stem cells (hWJ-MSCs) have gained considerable attention in their applications in cell-based therapy due to several advantages offered by them. Recently, we reported that hWJ-MSCs an

Released: 26-May-2022 12:00 PM EDT
Inhibition of glutathione metabolism can limit the development of pancreatic cancer
World Journal of Stem Cells

Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chem

Released: 26-May-2022 6:05 AM EDT
Drugs Used to Treat Blood Cancer Could Activate “Sleeping” Cancer-Causing Gene
National University of Singapore (NUS)

Hypomethylating agents (HMA) are currently used as a first-line treatment for patients with myelodysplastic syndrome (MDS) - a group of disorders where there is insufficient production of healthy mature blood cells in the bone marrow - and increasingly in other diseases, but their mechanism of action remains unclear.

Released: 25-May-2022 6:05 PM EDT
Prilenia announces publication of data elucidating a mechanism for neuroprotective potential of pridopidine
Prilenia

Prilenia Therapeutics B.V., a clinical stage biotechnology company focused on the urgent mission to develop novel therapeutics to slow the progression of neurodegenerative and neurodevelopmental disorders, today announced publication of its research in the peer-reviewed journal Autophagy which support pridopidine’s potential neuroprotective properties by enhancing autophagy in an amyotrophic lateral sclerosis (ALS) model.

Released: 25-May-2022 5:15 PM EDT
Double agents: How stomach stem cells change allegiance upon injury
Institute of Molecular Biotechnology

A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response.

Released: 25-May-2022 12:00 PM EDT
miR-582-5p regulates cell stemness and recurrence in bladder cancer via targeting CD81
Preprints

TianLei Xie, Zhongqing Zhang, Wenmin Cao, Wei Chen, Hongqian Guo, Junlong Zhuang

Released: 25-May-2022 12:00 PM EDT
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo/YAP pathway
Preprints

Lijun Wang, Lihui Wang, Rongli Wang, Ting Xu, Jingyuan Wang, Zhiwei Cui, Feiyan Cheng, Wei Wang, Xinyuan Yang

Released: 25-May-2022 12:00 PM EDT
Lineage-Specific Differences and Regulatory Networks Governing Human Chondrocyte Development
Preprints

Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, Pushpanathan Muthuirulan, Zun Liu, Terence D. Capellini, April M. Craft

Newswise: 5 Clean Energy Startups Chosen for Argonne’s Chain Reaction Innovations
Released: 25-May-2022 11:15 AM EDT
5 Clean Energy Startups Chosen for Argonne’s Chain Reaction Innovations
Argonne National Laboratory

Seven new innovators representing five clean energy startups will join Chain Reaction Innovations, Argonne National Laboratory’s entrepreneurship program, as part of the elite program’s sixth cohort.

Released: 24-May-2022 12:00 PM EDT
Body image in adolescent survivors of childhood cancer: the role of chronic health conditions
Preprints

Fabiën Belle, Tomáš Sláma, Christina Schindera, Tamara Diesch, Mutlu Kartal-Kaess, Claudia Kuehni, Luzius Mader

Released: 24-May-2022 12:00 PM EDT
Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells
Preprints

Tahir Haideri, Alessandro Howells, Yuqian Jiang, Jian Yang, Xiaoping Bao, Xiaojun Lian

Released: 24-May-2022 12:00 PM EDT
A CRISPR-dCas13 RNA-editing tool to study alternative splicing
Preprints

Yaiza Nunez-Alvarez, Tristan Espie--Caullet, Reini F Luco

Released: 23-May-2022 12:00 PM EDT
Public Cord Blood Banks as a source of starting material for clinical grade HLA-homozygous induced pluripotent stem cells
Preprints

Belen Alvarez-Palomo, Anna Veiga, Angel Raya, Margarita Codinach, Silvia Torrents, Laura Ponce Verdugo, Clara Rodriguez-Aierbe, Leopoldo Cuellar, Raquel Alenda, Cristina Arbona, Dolores Hernández-Maraver, Cristina Fusté, Sergi Querol

Released: 23-May-2022 12:00 PM EDT
Evaluating the Safety and Efficacy of MSCs-derived Exosomes for Treatment of Resistant Perianal Fistula in IBD patients; Clinical Trial Phase I
Preprints

Hojjatollah Nazari, Asieh Heirani, Masoud Soleimani, Reza Akbari Asbagh, Behnam Behboudi, Mohammad Sadegh Fazeli, Mojgan Rahimi, Mohammad Reza Keramati, Amir Keshvari, Alireza Kazemeini, Foroogh Alborzi, Seyed Mohsen Ahmadi Tafti

Released: 23-May-2022 12:00 PM EDT
Acceptance of Murine Islet Allografts Without Immunosuppression in the Inguinal Subcutaneous White Adipose Tissue Pretreated with bFGF
Preprints

Yuki Nakafusa, Naoyoshi Nitta, Kazunari Ishii, Naoto Shirasu, Takahiro Iwamoto, Takayuki Nemoto, Masafumi Nakamura, Masafumi Goto, Hiroo Iwata, Masaru Taniguchi, Yohichi Yasunami

Released: 23-May-2022 12:00 PM EDT
Multiplexed Microfluidic Platform for Stem-Cell Derived Pancreatic Islet β Cells
Preprints

Ishan Goswami, Eleonora de Klerk, Phichitpol Carnese, Matthias Hebrok, Kevin Healy

Released: 23-May-2022 12:00 PM EDT
Characteristics of anti-CLL1 based CAR-T therapy for children with relapsed or refractory acute myeloid leukemia: the multi-center efficacy and safety interim analysis
Preprints

Min Luo, Hui Zhang, Chaoke Bu, Zhiyong Peng, Guangchao Li, Zhao Zhou, Wen Ding, Yongwei Zheng, Yingyi He, Zhengbin Hu, Kunlin Pei, Chunfu Li

Released: 20-May-2022 12:00 PM EDT
Carbonic anhydrase IX-targeted chemodynamic & photodynamic cancer stem cell therapy
Preprints

Hyo Sung Jung, Seyoung Koo, Miae Won, Seeun An, Haebeen Park, Jonathan Sessler, Jiyou Han, Jong Seung Kim

Released: 19-May-2022 12:00 PM EDT
Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model
Preprints

Sudip Paul, Masamitsu Sone, Ashwini Patil, Hisaya Kato, Yoshiro Maezawa, Motohiko Oshima, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, Kyoko Tsujimura, Mahito Nakanishi, Atsushi Kaneda, Atsushi Iwama, Koutaro Yokote, Koji Eto, Naoya Takayama

Released: 19-May-2022 12:00 PM EDT
Mesenchymal Stromal Cells showed an alteration of differentiation potential under Environmental Micro and Nanoplastics Exposure
Preprints

Hana Najahi, Nicola Alessio, Tiziana Squillaro, Gea Oliveri Conti, Margherita Ferrante, Giovanni Di Bernardo, Umberto Galderisi, Imed Messaoudi, Sergio Minucci, Mohamed Banni

Released: 18-May-2022 12:00 PM EDT
Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis
Preprints

Takeshi Fujimori, Yuki Shibayama, Takahiro Kanda, Kenta Suzuki, Daisuke Ogawa, Ryo Ishikawa, Kyuichi Kadota, Toru Matsunaga, Keisuke Miyake, Akira Nishiyama, Takashi Tamiya

Released: 18-May-2022 12:00 PM EDT
High-throughput preclinical screening of CD123 scFv to design 3rd generation of CAR T-cell in the treatment of BPDCN patient
Preprints

Maxime Fredon, Margaux Poussard, Sabeha Biichle, Francis Bonnefoy, Evan Seffar, Elodie Bôle-Richard, Florian Renosi, Romain Boidot, François Anna, Maria Loustau, Julien Caumartin, Philippe Saas, Eric Deconinck, Etienne Daguindeau, Xavier Roussel, Olivier Adotevi, Fanny Angelot-Delettre, Jeanne Galaine, Francne Garnache-Ottou

Released: 17-May-2022 12:00 PM EDT
Downregulation of circBIRC6 and circCORO1C during differentiation of human cord blood-derived CD34 cells
Preprints

Roqaye Karimi, Amir Atashi, Mina Soufi Zomorrod, Monireh Agami, Mansoureh Ajami

Released: 17-May-2022 8:05 AM EDT
Vyriad, Inc. Raises $29.5M in Series B Funding Led by Renowned Genetics Entrepreneur
Vyriad, Inc.

Vyriad, Inc., a clinical-stage biotechnology company developing oncolytic virus therapies to treat a wide range of cancers, today announced $29.5M in new funding led by Mr. Harry Stine of Stine Seed Farms, Inc.

Released: 16-May-2022 12:00 PM EDT
A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies
Preprints

Céline Hervieu, Mireille Verdier, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet



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