A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease.
2-year-old Children's Hospital Los Angeles patient Pierce Kelly beats leukemia thanks to a stem cell donor in France and inspires thousands of potential donors.
Mohamad Cherry, MD, leads a major session on new discoveries about the most common type of acute adult leukemia and helps present results of four major blood cancer studies at the American Society of Hematology (ASH) 59th Annual Meeting, December 9-12 in Atlanta, GA. The meeting is the world’s pre-eminent gathering of clinicians and researchers focused on blood diseases, who travel from nearly 100 countries to hear the latest research developments. An internationally known hematology/oncology researcher, Dr. Cherry recently joined Atlantic Hematology Oncology, part of Atlantic Health System’s Atlantic Medical Group at Morristown Medical Center’s Carol G. Simon Cancer Center, from the University of Oklahoma Health Sciences Center’s Stephenson Cancer Center.
Engineers at the UC San Diego Center for Wearable Sensors have developed a smartphone case and app that could make it easier for patients to record and track their blood glucose readings, whether they’re at home or on the go.
Scientists have identified a mechanism that explains the development of hyperaldosteronism, a condition in which the adrenal glands produce too much aldosterone, The findings, published in JCI Insight, offer a path for drug discovery to treat the condition.
About half of people with blood clots in the deep veins of their legs develop a complication that involves chronic limb pain and swelling, making it difficult to walk and perform daily activities. A large-scale clinical trial has shown that a risky, costly procedure to remove such clot fails to reduce the likelihood that patients will develop the debilitating complication.
A team of gene therapy researchers has reported positive results in a phase 1/2 clinical trial for the inherited bleeding disorder hemophilia B. A single intravenous infusion of a novel bioengineered gene therapy treatment enabled adult participants to safely produce sustained levels of clotting factor that prevented debilitating bleeding episodes. Patients were able to terminate prophylactic treatments--the gene therapy nearly universally eliminated their need for intravenous infusions of manufactured clotting factor.
Spark Therapeutics (NASDAQ: ONCE), a fully integrated gene therapy company dedicated to challenging the inevitability of genetic disease, and Pfizer Inc. (NYSE:PFE), today announced that The New England Journal of Medicine has published interim data as of July 25, 2017, from the Phase 1/2 clinical trial of SPK-9001, an investigational gene therapy for hemophilia B.
Using zebrafish mutants in four different estrogen receptors, Daniel Gorelick has found a novel mechanism of estrogen action on heart physiology. Broader use of the mutants, he says, may have significant implications for studies of estrogenic environmental endocrine disruptors.
A clinical trial using genetic testing to match acute myeloid leukemia (AML) patients with new therapies is now open at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC). The center is one of seven cancer centers nationwide participating in the Beat AML® Master Trial, sponsored by the Leukemia & Lymphoma Society (LLS).
High blood pressure (hypertension) is redefined for the first time in 14 years by the American College of Cardiology and American Heart Association Task Force on Clinical Practice Guidelines.
Scientists at Seattle Children’s Research Institute have unlocked the ability to engineer B cells, uncovering a potential new cell therapy that could someday prevent and cure disease.
Using a database of multiple myeloma patient samples and information, researchers at University of California San Diego School of Medicine found that high ADAR1 levels correlate with reduced survival rates. They also determined that blocking the enzyme reduces multiple myeloma regeneration in experimental models derived from patient cancer cells.
Researchers from the Hackensack Merdian Health John Theurer Cancer Center at Hackensack University Medical Center will present results from 46 cancer-related studies during the American Society of Hematology (ASH) 59th Annual Meeting, which will take place December 9 – 12, 2017 in Atlanta. The studies examine new cancer treatments, ways to predict the best treatment outcomes, and patient quality of life issues.
New supercomputer simulations have revealed the role of transport proteins called efflux pumps in creating drug-resistance in bacteria, research that could lead to improving the drugs’ effectiveness against life-threatening diseases and restoring the efficacy of defunct antibiotics.
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers investigating novel stem cell-based treatments for acute myeloid leukemia or AML.
Researchers at The University of Texas MD Anderson Cancer Center will present their latest findings involving drug treatments for blood cancers at the American Society of Hematology’s (ASH) Annual Meeting & Exposition Dec. 8-12 in Atlanta.
St. Jude Children’s Research Hospital scientists report that combining the anti-malaria drug DHA with an emerging class of targeted agents may improve treatment of a high-risk acute lymphoblastic leukemia subtype
NYU Langone Health has announced that nationally renowned physician and researcher Raoul Tibes, MD, PhD, will lead efforts to expand the clinical and investigative leukemia programs at its Perlmutter Cancer Center.
Continuous glucose monitors (CGM) can protect individuals who have had type 1 diabetes for years and are at risk of experiencing dangerously low blood sugar by increasing their awareness of the symptoms, according to a study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
The following handbooks, produced by APHON, provide an overview for patients and their families on specific hematologic and oncologic diseases.
In a small study using data from daily electronic patient diaries, Johns Hopkins researchers say they have found a link between negative emotions, such as sadness and anxiety, and higher opioid use in people with sickle cell disease whose pain levels were self-reported as relatively low.
The final results of the DAWN study, published in The New England Journal of Medicine, show that select patients with stroke caused by a blood clot can be effectively treated with a procedure to remove the clot mechanically – and that this can be done up to 24 hours after the onset of symptoms.
By reducing out-of-pocket costs for preventive treatment, the Affordable Care Act appears to have encouraged more people to have health screenings related to their cardiovascular health, a UCLA study found.
A study of more than 400 adults with prehypertension, or stage 1 high blood pressure, found that combining a low-salt diet with the heart-healthy DASH diet substantially lowers systolic blood pressure — the top number in a blood pressure test — especially in people with higher baseline systolic readings.
Anyah wasn't going to let sickle cell disease keep her from going on her high school class trip to Europe. Thanks to Natalie Kamberos, DO, and the care Anyah received at Loyola Medicine, Anyah was able to climb the Eiffel Tower and make it a trip of a lifetime.
A grant from The Leukemia & Lymphoma Society will help fund clinical research led by UNC Lineberger's Barbara Savoldo, MD, PhD, into an investigational chimeric antigen receptor (CAR) T-cell treatment for acute lymphoblastic leukemia that would include a built-in "safety switch."
Drugs designed to halt cancer growth may offer a new way to control high blood pressure (hypertension), say Georgetown University Medical Center investigators. The finding could offer a real advance in hypertension treatment because although a number of high blood pressure drugs are now available, they work by different mechanisms that are not suited for all patients.
Seattle Children’s has opened the first chimeric antigen receptor (CAR) T-cell immunotherapy trial in the U.S. for children and young adults with relapsed or refractory CD19- and CD22-positive acute lymphoblastic leukemia (ALL) that will simultaneously attack two targets on cancer cells.
Using a different marker to track a patient’s glycemic levels could help improve outcomes after surgery for diabetic and non-diabetic patients alike.
Tulane University’s Stryder Meadows, a cell and molecular biology professor, received a $1.7 million grant from the Department of Defense to study how arteriovenous malformations (AVM), which are defects in arteries, veins and capillaries, form Hereditary Hemorrhagic Telangiectasia (HHT), a genetic disorder that affects about 1 in 5,000 people.
Individuals who have A, B, or AB blood types have an elevated risk of having a heart attack during periods of significant air pollution, compared to those with the O blood type, according to a new study from the Intermountain Medical Center Heart Institute and Brigham Young University.
Biomedical scientists at the University of California, Riverside have identified a hormone that may lead to improved survival rates for patients with sepsis. Using a mouse model, they have discovered that the human protein resistin could be used to treat this medical emergency. The researchers found that mice expressing human resistin had a 100 percent survival rate from a sepsis-like infection when compared to wild-type mice with the same infection.
Extreme ups and downs in systolic blood pressure may be just as deadly as having consistently high blood pressure, according to a new study from the Intermountain Medical Center Heart Institute in Salt Lake City.
In a large population study that was the first of its kind, researchers found that a simple tool not requiring laboratory tests, the Fuster-BEWAT score, is as effective as the American Heart Association-recommended ICHS (Ideal Cardiovascular Health Index), which includes blood analysis of cholesterol and glucose.
A novel computational method allows researchers to parse how multiple organs contribute to a disease over time, giving a more holistic view of disease and potentially revealing new avenues for intervention.
St. Jude Children’s Research Hospital researchers report that maximizing the dose of hydroxyurea increased levels of fetal hemoglobin and reduced the odds of hospitalizations for young sickle cell anemia patients.
Older people whose hearts pump less blood may have reduced blood flow in the memory-processing areas of the brain, according to a study published in the November 8, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The Endocrine Society issued a new Scientific Statement today examining how diabetes damages the body’s smallest blood vessels as well as how the condition affects the body’s natural repair processes designed to protect the eyes, kidneys, nerves and other organs.
Researchers will meet to discuss the physiology, function and future of red blood cells (RBCs) in sickle cell disease (SCD) at the “Red Cell Physiology” symposium during the American Physiological Society’s Physiological and Pathophysiological Consequences of Sickle Cell Disease conference in Washington, D.C.
The first view of the physical mechanism of how a blood clot contracts at the level of individual platelets is giving researchers a new look at a natural process that is part of blood clotting. The team describes how specialized proteins in platelets cause clots to shrink in size.
Rural counties continue to rank lowest among counties across the U.S., in terms of health outcomes. A group of national organizations including the Robert Wood Johnson Foundation and the National 4-H Council are leading the way to close the rural health gap.
For the ninth year in a row, Loyola University Medical Center has received the American Heart Association/American Stroke Association's Get With The Guidelines®-Stroke Gold Plus Quality Achievement Award.
Pregnant women today are more likely to have chronic conditions that could cause life-threatening complications than at any other time in the past decade – particularly poor women and those living in rural communities.
An overabundance of the bacteria Veillonella in the digestive tract may increase pain in patients with sickle cell disease (SCD). Researchers from Howard University will present their findings today at the American Physiological Society’s Physiological and Pathophysiological Consequences of Sickle Cell Disease conference in Washington, D.C.
Researchers have found a genotype that could help identify sickle cell disease (SCD) patients at greatest risk of developing disease-related complications. The findings will be presented at the APS Physiological and Pathophysiological Consequences of Sickle Cell Disease conference.
Mental stress and the anticipation of pain may cause blood vessels to narrow and trigger episodes of severe pain (vaso-occlusive crisis, or VOC) in sickle cell disease (SCD). A team of researchers from California will present their findings today at the American Physiological Society’s Physiological and Pathophysiological Consequences of Sickle Cell Disease conference in Washington, D.C.
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