New research explores stem cells in the rotator cuff in hopes of understanding why fatty accumulation happens at the tear site, instead of proper muscle healing.
Several Roswell Park Comprehensive Cancer Center experts were invited to highlight research and best practices during the TCT/Transplantation and Cellular Therapy Meetings now underway in Houston, Texas.
诱导性多能干细胞可谓是许多再生医学项目的主力军，这些细胞最初为分化细胞，其通过接触一组复杂的基因鸡尾酒而成为能被重编程为多能干细胞。根据Mayo研究人员报告，现在通过使用麻疹病毒载体，能够将这一具有4个重编程因子的多载体过程精简成一个“单周期”载体过程。据称，该过程安全、稳定、速度更快，且可用于临床转化。本研究结果发表于《基因治疗》(Gene Therapy)期刊。
Research led by Johns Hopkins investigators has uncovered the roles of two types of cells found in the vessel walls of fat tissue and described how these cells may help speed bone repair.
As células-tronco pluripotentes induzidas, o trabalho intenso de muitos projetos médicos regenerativos, começam como células diferenciadas que são reprogramadas para células-tronco pluripotentes por meio da exposição a uma série complexa de coquetéis genéticos. Pesquisadores da Mayo Clinic agora relatam que usando o vetor do vírus do sarampo eles reduziram o processo de multivetor de quatro fatores de reprogramação para um único processo de vetor de “um ciclo”.
تبدأ الخلايا الجذعية متعددة القدرات المستحثة، التي تعد العمود الفقري للعديد من مشروعات الطب التجديدي، كخلايا متباينة يتم إعادة برمجتها إلى خلايا جذعية متعددة القدرات عن طريق التعرض لمجموعة معقدة من مزيج من الجينات. أفاد باحثو Mayo الآن باستخدام ناقل فيروس الحصبة؛ فلقد قاموا بتقليص العمليات المتعددة الناقلات ذات عوامل إعادة البرمجة الأربعة إلى عملية ناقلات فردية "دورة واحدة". يقولون إن العملية آمنة ومستقرة وأسرع ويمكن استخدامها للترجمة السريرية. تظهر النتائج في مجلة Gene Therapy.
Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson's disease (PD) in future. Writing in a special supplement to the Journal of Parkinson's Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment.
Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails.
Why are fat deposits more likely to occur after tears of the shoulder’s rotator cuff, compared to other types of muscle injuries? An increased propensity of stem cells within with rotator cuff muscles to develop into fat cells may explain the difference, reports a study in the February 6, 2019 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
Using a leading-edge technique, UC San Diego School of Medicine researchers defined the cell types in both newborn and adult human testes and identified biomarkers for spermatogonial stem cells, opening a path for new strategies to treat male infertility.
The first U.S. patient to participate in a global study of a stem cell therapy injected directly into the brain to treat stroke disability was enrolled in the clinical trial this week at The University of Texas Health Science Center at Houston (UTHealth).
Using induced pluripotent stem cell-derived neurons from Alzheimer’s patients, UC San Diego researchers say cholesteryl esters — the storage product for excess cholesterol within cells — act as regulators of the protein tau, providing a new druggable target for the disease.
Scientists at the Unviersity of Kentucky have assembled the entire genome of the Mexican Axolotl, the key to unlocking the secrets of regeneration with potential for life-changing clinical applications down the road.
A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells — which can give rise to every cell type in the body and which can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells.
Researchers at Washington University School of Medicine in St. Louis have tweaked the recipe for coaxing human stem cells into insulin-secreting beta cells and shown that the resulting cells are more responsive to fluctuating glucose levels in the blood.
Using a novel patient-specific stem cell-based therapy, researchers at the National Eye Institute (NEI) prevented blindness in animal models of geographic atrophy, the advanced “dry” form of age-related macular degeneration (AMD), which is a leading cause of vision loss among people age 65 and older. The protocols established by the animal study, published January 16 in Science Translational Medicine (STM), set the stage for a first-in-human clinical trial testing the therapy in people with geographic atrophy, for which there is currently no treatment.
Changes in blood vessels are the major cause of death and morbidity in diabetes. For the first time, sci-entists managed to grow perfect human blood vessels as organoids in a petri dish. This breakthrough engineering technology dramatically advances research of vascular dysfunction in diseases like diabetes, identifying a key pathway that prevents diabetic vasculopathy, as reported in the current issue of Nature.
New study uses live imaging to understand a critical step in early embryonic development—how genes and molecules control forces to orchestrate the emergence of form in the developing embryo. The study findings could have important implications for how stem cells are used to create functional organs in the lab, and lead to a better understanding of the underlying causes of gastrointestinal birth defects.
NIBIB-funded researchers have developed a 3D-printed scaffold coated in aggrecan, a native cartilage component, to improve the regeneration of cartilage tissue in joints. The scaffold was combined with a common microfracture procedure and tested in rabbits. The University of Maryland researchers found the combination of the implant and microfracture procedure to be ten times more effective than microfracture alone.
In a randomized clinical trial, researchers compared the effect of a stem cell transplant using a non-myeloablative regimen (a lower-dose, short course of more tolerable immune specific chemotherapy and antibodies to suppress the immune system) versus continuing disease-modifying therapy in 110 patients with relapsing-remitting multiple sclerosis.
Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have demonstrated that muscle stem cells may give rise to rhabdomyosarcoma that occurs during DMD—and identified two genes linked to the tumor’s growth. The research, performed using a mouse model of severe DMD, helps scientists better understand how rhabdomyosarcoma develops in DMD—and indicates that ongoing efforts to develop treatments that stimulate muscle stem cells should consider potential cancer risk. The study was published today in Cell Reports.
For the first time, researchers at University of California San Diego have used rapid 3D printing technologies to create a spinal cord, then successfully implanted that scaffolding, loaded with neural stem cells, into sites of severe spinal cord injury in rats.
The collaborative research between the Kornberg School of Dentistry and the College of Engineering uses stem cells to regrow the pulp-dentin complex that makes up the center of a tooth.
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. The findings could bring about a better understanding of many cancers' metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer.
A special edition of National Geographic on "The Future of Medicine" highlights the innovative stem-cell science of Cedars-Sinai, showing how investigators are seeking to use stem cells and Organ-Chips to tailor personalized treatments for individual patients. Downloadable video available.
Hackensack Meridian Health Hackensack University Medical Center recently held the third annual Blood and Marrow Transplant (BMT) RN Fellowship Graduation Ceremony for nine registered nurses. The nurses are from 8PE and 8PW Blood and Marrow Transplant (BMT) units.
In experiments in rats and human cells, Johns Hopkins Medicine researchers say they have added to evidence that a cellular protein signal that drives both bone and fat formation in selected stem cells can be manipulated to favor bone building.
UC San Diego researchers have found a stem cell enzyme copy edits more than 20 tumor types, providing new therapeutic target for preventing cancer cell resistance to chemotherapy and radiation.
The healing of wounded skin in diabetes can be sped up by more than 50 percent using injections of stem cells taken from bone marrow, a new study in mice shows.
About 3.4 million Americans, or 1.2 percent of the population, have active epilepsy. Although the majority respond to medication, between 20 and 40 percent of patients with epilepsy continue to have seizures even after trying multiple anti-seizure drugs.
A team of Rutgers scientists have taken an important step toward the goal of making diseased hearts heal themselves – a new model that would reduce the need for bypass surgery, heart transplants or artificial pumping devices.
A new study by UCLA scientists shows that enhancers, snippets of DNA that contribute to gene regulation, fall into the same “insulated neighborhoods” or chromatin loops as the target gene and other gene-specific regulatory elements.
In an effort to better understand frontotemporal dementia, an international team of researchers, led by Washington University School of Medicine in St. Louis, has found that a lone mutation in a single gene that causes an inherited form of the disorder makes it harder for neurons in the brain to communicate with one another, leading to neurodegeneration.
A company in Israel has unveiled the world’s first lab-grown steak, grown in a petri dish with the taste and texture of one that comes from a cow. Jan Dutkiewicz, a postdoctoral fellow in political science at Johns Hopkins University has researched the emergence of cellular agriculture. He is available to talk about the new steak and offer perspective on the development.
Summaries of recent Fred Hutch research with links for additional background and media contacts.
Duke Health researchers have previously shown that introducing bone marrow stem cells to a bone injury can expedite healing, but the exact process was unclear. Now, the same Duke-led team believes it has pinpointed the “youth factor” inside bone marrow stem cells -- it’s the macrophage, a type of white blood cell, and the proteins it secretes that can have a rejuvenating effect on tissue. Nature Communications will publish the findings online on Dec. 5.
The National Eye Institute (NEI) awarded $25,000 to a team led by Wei Liu, Ph.D., Albert Einstein College of Medicine, for demonstrating progress toward the development of a living model of the human retina, the light-sensitive tissue at the back of the eye. The prize money was awarded for the first of two phases of the NEI 3-D Retina Organoid Challenge 2020 (3-D ROC 2020), a national initiative to generate human retina organoids from stem cells. NEI is part of the National Institutes of Health.
Umbilical cord blood stem cells that are cultured and expanded outside the body before being used for bone marrow transplant in adult blood cancer patients appear safe and restore blood count recovery faster than standard cord blood. The findings, led by a Duke Cancer Institute researcher, advance efforts to improve cord blood use among adults who have been diagnosed with blood cancers.
An international phase-2 trial of a CAR-T cell therapy—to be published on-line Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego)—found that 52% of patients responded favorably to the therapy; 40% had a complete response and 12% had a partial response. One year later, 65% of those patients were relapse-free, including 79% of complete responders. The median progression-free survival “has not been reached.”
MSK experts in CAR-T therapy, immunotherapy, leukemia, lymphoma, blood and marrow stem cell transplantation, and more, are also available to comment on meeting news.
A material based on a natural product of bones and citrus fruits, called citrate, provides the extra energy stem cells need to form new bone tissue, according to a team of Penn State bioengineers.
A protein found in healing muscles of younger mice helps older animals bounce back from injury.
The American College of Rheumatology (ACR) welcomes members of the press to write about rheumatology research presented the Winter Rheumatology Symposium in Snowmass Village, CO on January 26 to February 1, 2019.
New research has identified rogue cells – namely brain and muscle cells – lurking within kidney organoids. The presence of such cells indicates that the “recipes” used to coax stem cells into becoming kidney cells inadvertently are churning out other cell types.
University of Nebraska Medical Center leading national team to determine if ruxolitinib is effective for treating a certain type of graft versus host disease (GVHD) called sclerotic. The grant is funded by Incyte, a global biopharmaceutical company.
A crowdfunding campaign launched today (Tuesday 13 November) by the University of Adelaide aims to help save the Tasmanian devil, one of Australia’s most iconic but endangered animals.
CU Cancer Center study shows that cancer stem cells switch from metabolizing sugar to metabolizing protein. Turning off protein metabolism kills these cells.
An international team led by Montreal researchers discovers two proteins essential to the development of skeletal muscle.
With their new finding, Canadian scientists urge revision of decades-old dogma on protein synthesis
A Rutgers Cancer Institute of New Jersey researcher has received a $150,000 grant from the Lung Cancer Research Foundation to investigateautophagy in the development of lung cancers driven by mutations in tumor suppressors known as LKB1 and oncogene KRAS.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right