The accumulation of age-associated changes in a biochemical process that helps control genes may be responsible for some of the increased risk of cancer seen in older people, according to a National Institutes of Health study.
A chemical that's found in fruits and vegetables from strawberries to cucumbers appears to stop memory loss that accompanies Alzheimer's disease in mice, scientists at the Salk Institute for Biological Studies have discovered. In experiments on mice that normally develop Alzheimer's symptoms less than a year after birth, a daily dose of the compound----a flavonol called fisetin----prevented the progressive memory and learning impairments. The drug, however, did not alter the formation of amyloid plaques in the brain, accumulations of proteins which are commonly blamed for Alzheimer's disease. The new finding suggests a way to treat Alzheimer's symptoms independently of targeting amyloid plaques.
The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen. To develop better methods of protection from the sun, we need to understand how the human skin detects and responds to UVR. Researchers provide new insight into the molecular pathway underlying this process.
Researchers at UAB say that high-intensity strength training produced significant improvements in quality of life, mood and motor function in older patients with Parkinson’s disease. The findings were published Jan. 9 online in the Journal of Applied Physiology.
A new study from the Florida campus of The Scripps Research Institute offers insights into how aging affects the brain’s neural circuitry, in some cases significantly altering gene expression in single neurons.
Nearly half of hospitalized American adults age 65 and older require decision-making assistance from family members or other surrogates because the patient is too impaired to make decisions independently, according to a new study from the Regenstrief Institute and the Indiana University Center for Aging Research.
Older women who spend a majority of their day sitting or lying down are at increased risk for cardiovascular disease, coronary heart disease, cancer and death, finds a new study from the American Journal of Preventive Medicine.
Aging gracefully may not be an option for the 40 million people worldwide who are blind or have significant visual impairment. It’s reported that 65% of those with visual impairment and 82% of those who are blind are over 50 years of age. In a special issue of Investigative Ophthalmology & Visual Science (IOVS), ophthalmic leaders from around the world address “the aging eye” to focus attention on unmet needs and accelerate the translation of research findings into effective clinical care.
By sitting less and moving more, people can reduce their risks of chronic diseases and make aging easier, according to Kansas State University research.
Louis Medvene, Wichita State University professor of psychology and director of the Social Relationships Research Workgroup, is exploring the potential benefits of computer access to senior citizens' health.
Virtual reality, dance and fun are not the first things that come to mind when we think of treating urinary incontinence in senior women. However, these concepts were the foundations of a promising study .
Minority of panel members who disagree with raising systolic blood pressure targets for people over 60 years of age provide their evidence in a new commentary in the Annals of Internal Medicine.
Psychology researchers find parents set themselves up for speech errors when they give their children similar-sounding names.
Highly diverse cancers share one trait: the capacity for endless cell division. Unregulated growth is due in large part to the fact that tumor cells can rebuild protective ends of their chromosomes, which are made of repeated DNA sequences and proteins. Normally, cell division halts once these structures, called telomeres, wear down. But cancer cells keep on going by deploying one of two strategies to reconstruct telomeres.
Using high-resolution fMRI imaging in patients with Alzheimer's disease and in mouse models of the disease, researchers have clarified three fundamental issues about Alzheimer's: where it starts, why it starts there, and how it spreads. In addition to advancing understanding of Alzheimer's, the findings could improve early detection of the disease, when drugs may be most effective. The study was published today in the online edition of the journal Nature Neuroscience.
Most people with dementia who live at home have multiple unmet health and welfare needs, any number of which could jeopardize their ability to remain home for as long as they desire, new Johns Hopkins research suggests.
The study identifies a common, early marker of senescent cells that could have important implications for tumor suppression and aging-related diseases like Progeria
For the first time, researchers describe the effect of sleep deprivation on the unfolded protein response in peripheral tissue. Stress in pancreatic cells due to sleep deprivation may contribute to the loss or dysfunction of cells important to maintaining proper blood sugar levels, and that these functions may be exacerbated by normal aging. The combined effect of aging and sleep deprivation resulted in a loss of control of blood sugar, somewhat like pre-diabetes in mice.
A low level of daily exposure to a common component of sunlight can cause skin damage at the molecular level after just a few days, new research shows. The findings highlight the need for better sunscreens to protect against these damaging rays.
A recent paper by Mass. Eye and Ear/Harvard Medical School researchers in collaboration with researchers at the Ecole Normale Superieure, France, challenge the two dominant theories of how people localize sounds, explain why neuronal responses to sounds are so diverse and show how sound can be localized, even with the absence of one half of the brain. Their research is described on line in the journal eLife.
Mount Sinai researchers show that synaptic health in the brain is closely linked to cognitive decline. Further, they discover that estrogen restores synaptic health and also improves working memory.
Scientists at The Scripps Research Institute have discovered a natural mechanism that cells use to protect mitochondria, the tiny but essential “power plants” that provide chemical energy for cells throughout the body.
In their study, Sylvie Belleville and her team accurately predicted (at a rate of 90%) which of their research subjects with mild cognitive impairment would receive a clinical diagnosis of Alzheimer's disease within the following two years and which subjects would not develop this disease.
Sexually frustrated fruit flies lived shorter lives.
Improvements in education levels, health care and lifestyle credited for decline in dementia risk.
A year after a trauma injury, seniors had difficulty with daily tasks such as simple shopping trips.
As 10,000 baby boomers reach 65 each day, the incidence of cancer is increasing, estimated to increase by 67% between 2010 and 2030, bringing attention to the nation’s response to cancer care. Cancer is diagnosed at a higher rate, accounts for more survivors, and results in more deaths than in younger patients.
As we age, our body rhythms lose time before they finally stop. Breaking the body clock by genetically disrupting a core clock gene, Bmal1, in mice has long been known to accelerate aging , causing arthritis, hair loss, cataracts, and premature death. New research now reveals that the nerve cells of these mice with broken clocks show signs of deterioration before the externally visible signs of aging are apparent, raising the possibility of novel approaches to staving off or delaying neurodegeneration.
Dana Hayden, MD, Loyola colorectal surgeon, points out that 15 million women ages 40 and older (1 in 5) suffer from accidental bowel leakage. “Fecal incontinence is not a part of normal aging. It is a medical condition and there is treatment available,” says Hayden. “People with this condition become inhibited, stop socializing and do not even complete everyday routines such as grocery shopping or going to church because they fear an accident.” Loyola is one of the first medical institutions to offer a new outpatient procedure for fecal incontinence that often results in immediate improvement. In the new procedure, a gel is given through four injections into the wall of the anal canal.
Our epigenome is a set of chemical switches that turn parts of our genome off and on and are impacted by environmental factors including diet, exercise and stress. Research at the Buck Institute reveals that aging also effects the epigenome in human skeletal muscle. The study provides a method to study sarcopenia, the degenerative loss of muscle mass that begins in middle age.
The progressive loss of skeletal muscle during aging, known as sarcopenia, underlies limitations in physical function and mobility, which in turn lead to falls, loss of independence, institutionalization and even death. Mayo Clinic researcher Nathan LeBrasseur, Ph.D., of Mayo Clinic’s Robert and Arlene Kogod Center on Aging and Department of Physical Medicine and Rehabilitation, presented an update on promising strategies and therapies to restore skeletal muscle health in the face of aging and disease during a symposium at the American Congress of Rehabilitation Medicine Annual Conference.
Stanford University researchers say surgical weight loss may turn back the effects of aging at a genetic level, in the first study* of its kind presented here during ObesityWeek 2013.
People in middle age who have a high blood pressure measure called pulse pressure are more likely to have biomarkers of Alzheimer’s disease in their spinal fluid than those with lower pulse pressure, according to research published in the November 13, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The novel compound IRL-1620 may be useful in treating Alzheimer’s disease (AD) as it has been shown to prevent cognitive impairment and oxidative stress in animal models.
Groundbreaking clinical study shows patented magnesium formula prevents synapse loss and reverses memory decline in mice with Alzheimer’s Disease.
UAB experts have advice on how to slow aging, and how this can help with appearance and self-esteem.
On Nov. 6, 12:30-1 pm PST, Nobel Laureate Dr. Eric R. Kandel, and Drs. Elias Pavlopoulos and Scott A. Small, will answer questions about compelling new evidence that age-related memory loss is a syndrome in its own right, apart from Alzheimer’s.
Older individuals hospitalized with a serious condition may face a slimmer risk of surviving if their thyroid hormone levels are low, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
The effects of gravity may explain the apparently paradoxical effects of testosterone in male pattern baldness, or androgenic alopecia (AGA), according to a special topic paper in Plastic and Reconstructive Surgery—Global Open®, the official open-access medical journal of the American Society of Plastic Surgeons (ASPS).
The major genetic risk factor for Alzheimer’s disease, present in about two-thirds of people who develop it, is ApoE4, the cholesterol-carrying protein that about a quarter of us are born with. But one of the unsolved mysteries of AD is how ApoE4 causes this risk. Researchers at the Buck Institute have found a link between ApoE4 and SirT1, an “anti-aging protein” that is targeted by resveratrol, present in red wine.
Can complex thinking stave off the effects of aging? A new study from the University of Texas at Dallas shows that learning new, mentally challenging tasks, such as digital photography, improves memory in seniors, while less demanding tasks, such as socializing or playing simple games, does not.
Researchers at Columbia University Medical Center (CUMC) have devised a hair restoration method that can generate new human hair growth, rather than simply redistribute hair from one part of the scalp to another. The approach could significantly expand the use of hair transplantation to women with hair loss, who tend to have insufficient donor hair, as well as to men in early stages of baldness. The study was published today in the online edition of the Proceedings of the National Academy of Sciences (PNAS).
A UCLA study is the first to identify a biological clock able to gauge the age of most human tissues. Some parts of the anatomy, like a woman’s breasts, age faster than the rest of the body.
Scientists report in Nature they have found a novel and unexpected molecular switch that could become a key to slowing some of the ravages of getting older as it prompts blood stem cells to age.
Even for elderly people with no signs of dementia, those with hardening of the arteries are more likely to also have the beta-amyloid plaques in the brain that are a hallmark of Alzheimer’s disease, according to a study published in the October 16, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Have you ever wondered why young children can eat bags of Halloween candy and feel fine the next day – compared to adults who experience all sorts of agony following the same junk food binge? Evolution and a gene called Foxo may be to blame.
A new study of women ages 50 and older examines the 12.2 percent who say they are satisfied with their body size to unlock the secrets of body satisfaction. This minority of midlife women who report being satisfied with their body size appears to exert considerable effort to achieve and maintain this satisfaction.
Elderly surgical patients are more likely to suffer from debilitating post-operative delirium if they have diabetes, undergo longer surgery or respond poorly to stress, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting.
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