A technique to combine the ultrasensitivity of surface enhanced Raman scattering (SERS) with a slippery surface invented by Penn State researchers will make it feasible to detect single molecules of a number of chemical and biological species from gaseous, liquid or solid samples.
University of Louisville researchers recently received a patent on a synthetic biochemical compound and its variants, moving science closer to a treatment for gum disease.
A research team including NIBIB-funded scientists have developed a sunscreen that encapsulates the UV-blocking compounds inside bio-adhesive nanoparticles, which adhere to the skin well, but do not penetrate beyond the skin’s surface. These properties resulted in highly effective UV protection in a mouse model, without the adverse effects observed with commercial sunscreens, including penetration into the bloodstream and generation of reactive oxygen species, which can damage DNA and lead to cancer.
Cardiovascular diseases are among the most frequent causes of death worldwide. The ability to repair a damaged heart is one of the grand visions of medical science. Cardiac regeneration is possible in fish and in newborn mice. But so far it has not been known whether human hearts can regenerate as well. Scientists at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna and the Innsbruck Medical University have described the first complete clinical and functional repair of a human heart following an acute heart attack in an infant. This astonishing discovery nourishes hope that cardiac repair in humans might be possible in the future.
A team of researchers at Kansas State University, the University of Missouri and global agricultural biotechnology company Genus plc has developed pigs that are resistant to the most devastating disease in the swine industry.
Led by Columbia Engineering professor Ken Shepard, researchers have, for the first time, harnessed the molecular machinery of living systems to power an integrated circuit from ATP, the energy currency of life. They achieved this by integrating a conventional solid-state complementary metal-oxide-semiconductor (CMOS) integrated circuit with an artificial lipid bilayer membrane containing ATP-powered ion pumps, opening the door to creating entirely new artificial systems that contain both biological and solid-state components. (Nature Communications 12/7)
Linda Chelico and her team are learning more about how an ancient “error correction” system in the human genome helps protect the body against HIV.
Biomedical informatics, one of the world’s fastest-growing interdisciplinary fields, is the latest graduate degree program offered by the University of Chicago Graham School of Continuing Liberal and Professional Studies.
Researchers at University of California, San Diego School of Medicine, Ludwig Cancer Research and Isis Pharmaceuticals demonstrate a commercially feasible way to use RNA to turn the CRISPR-Cas9 system on and off as desired — permanently editing a gene, but only temporarily activating CRISPR-Cas9. The study is published November 16 by Proceedings of the National Academy of Sciences.
Katherine Lau used her biomedical engineering know-how to help create a prosthesis for a 4-year-old girl using 3-D printing.
Cornell biomedical engineers have developed specialized white blood cells – dubbed “super natural killer cells” – that seek out cancer cells in lymph nodes with only one purpose: destroy them.
Scientists from Nanyang Technological University (NTU Singapore) have successfully used dead bacteria to kill colorectal cancer cells.
Building on wireless technology that has the potential to interfere with pain, scientists have developed flexible, implantable devices that can activate -- and, in theory, block -- pain signals in the body and spinal cord before those signals reach the brain. The researchers, at Washington University School of Medicine in St. Louis and the University of Illinois at Urbana-Champaign, said the implants one day may be used in different parts of the body to fight pain that doesn't respond to other therapies.
Findings published in national journal
Scientists at Mount Sinai create immune cells that visibly kill cancer and pathogen infected cells
Scientists aspire to build nanostructures that mimic the complexity and function of nature’s proteins. These microscopic widgets could be customized into incredibly sensitive chemical detectors or long-lasting catalysts. But as with any craft that requires extreme precision, researchers must first learn how to finesse the materials they’ll use to build these structures. A discovery by Berkeley Lab scientists is a big step in this direction. The scientists discovered a design rule that enables a recently created material to exist.
A team of scientists at the University of Washington and the biotechnology company Illumina have created an innovative tool to directly detect the delicate, single-molecule interactions between DNA and enzymatic proteins.
Public and private entities that fund biomedical research face difficult choices on how to allocate a finite level of capital, and scientists often take risks in selecting research topics multiple times in their academic careers. UNC Charlotte data scientist Lixia Yao, in a recently published article in Nature Biotechnology titled “Health ROI as a Measure of Misalignment of Biomedical Needs and Resources,” suggests a better method for those funding agencies and scientists.
researchers from the University of Zurich, Switzerland have made a breakthrough by obtaining the first nanometer (one billionth of a meter) resolved image of individual tobacco mosaic virions, a rod-shaped RNA virus that infects a wide range of plants, especially tobacco. The work demonstrates the potential of low-energy electron holography as a non-destructive, single-particle imaging technique for structural biology. The researchers describe their work in a paper published this week on the cover of the journal Applied Physics Letters, from AIP Publishing.
Researchers from the Icahn School of Medicine at Mount Sinai and Princeton University have designed a new online tool that predicts the role of key proteins and genes in diseases of the human immune system.
The findings of Virginia Tech’s Biomedical and Engineering Mechanics Associate Professor Sunghwan “Sunny” Jung and his students on somersaulting single-cell organisms could impact the study of how the containment affects the behavior of organisms, used in a wide variety of engineering and scientific applications.
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
Other topics include genetics to predict prostate cancer, Facebook and body image, bioengineered immune cell response, and more...
In recent years, immunotherapy has emerged as a promising treatment for certain cancers. Now this strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable. The results appeared in a study published online today in Nature Medicine.
North Carolina State University researchers have developed an effective and environmentally benign method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin, a ubiquitous substance found in all plant cells. The findings introduce ideas for better, greener and safer nanotechnology and could lead to enhanced efficiency of antimicrobial products used in agriculture and personal care.
A new study led by University of Kentucky researchers suggests a new approach to develop highly-potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
Researchers have developed a new approach for better integrating medical devices with biological systems. The researchers, led by Bozhi Tian, assistant professor in chemistry at the University of Chicago, have developed the first skeleton-like silicon spicules ever prepared via chemical processes.
Other topics include repairing injured nerves, busted heart attack treatment, decorative brain molecules, and more...
Studying brain scans and cerebrospinal fluid of healthy adults, scientists have shown that changes in key biomarkers of Alzheimer's disease during midlife may help identify those who will develop dementia years later, according to new research.
Other topics include memories and protein, physics and gas mileage, agriculture and food safety, vaccine for Dengue, retinoblastoma proteins in cancer progression, and more.
Researchers at the University of Adelaide have discovered a new method for culturing stem cells which sees the highly therapeutic cells grow faster and stronger.
A review article published on the journal Oncotarget focusing on RB role in apoptosis provides a comprehensive overview on the role of RB proteins in the coordinated control of cell decisions.
NIBIB-supported researchers have created tiny gel particles that can perform the same essential functions as platelets. The particles could one day be used to control excessive bleeding following traumatic injury or in individuals with impaired clotting due to an inherited condition or as a result of certain medications or chemotherapy.
Other topics include; grape seed oil to reduce obesity, gender differences in chronic pain, workplace wellness, healthcare in rural Africa after Ebola, cancer treatment, and finding a cure for MERS.
Other topics include weight loss, medical marijuana, smart traffic lights, diabetes, heart disease, and more.
Other topics include dietary guidelines, smart traffic lights, breast cancer, and biomarker tests for cancer treatment.
Using optogenetics, researchers have established a new approach for pacing the heart and synchronizing its mechanical activity without a conventional electrical pacemaker. Could help avoid many drawbacks of electrical pacemakers.
Researchers have discovered two strategies that enable Saharan silver ants to stay cool in one of the world’s hottest environments. They are the first to demonstrate that the ants use a coat of uniquely shaped hairs to control electromagnetic waves over an extremely broad range from the solar spectrum to the thermal radiation spectrum and that different physical mechanisms are used in different spectral bands to realize the same biological function of reducing body temperature.
Despite the intense activity and high hopes that surround the use of stem cells to reverse heart disease, scientists still face multiple roadblocks before the treatment will be ready for clinical prime time. Researchers are now finding ways to maximize the healing potential of stem cells by helping them overcome the inhospitable conditions of a damaged heart – bringing the promise of stem cell therapy for heart disease one step closer to reality.
A preclinical study is set to determining the effectiveness of its Cell-in-a-Box(R) live-cell encapsulation technology together with the anticancer drug, ifosfamide, in slowing the accumulation of fluid in the abdomen that accompanies the growth of pancreatic and other abdominal cancerous tumors.
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There’s an urgent demand for new antimicrobial compounds that are effective against constantly emerging drug-resistant bacteria. Two robotic chemical-synthesizing machines at the Molecular Foundry have joined the search.
In Science Advances, University at Buffalo researchers will report that they have managed to turn E. coli into tiny factories for producing new forms of the popular antibiotic erythromycin — including three that were shown in the lab to kill drug-resistant bacteria.
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Researchers have uncovered a new molecular mechanism - a function of the NONO protein - whereby cells protect their genome from the detrimental effect of UV radiation and govern DNA replication in cellular mitosis. A recent study investigates what happens when this molecular mechanism malfunctions.
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Researchers at the La Jolla Institute for Allergy and Immunology, in collaboration with colleagues the University of California, San Diego, identified a novel drug target for the treatment of rheumatoid arthritis that focuses on the cells that are directly responsible for the cartilage damage in affected joints.
A team of Dartmouth investigators have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor.
The most detailed study to date showing how electrical stimulation accelerates wound healing has been carried out in 40 volunteers by University of Manchester scientists.
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