Feature Channels: Pharmaceuticals

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Researchers at Montana Technological University have developed a portable electrospinning device with a confined electric field that can safely deposit bandages and drugs directly onto biological surfaces, using air to spray the fibers out onto the surface, like a can of spray paint. The device can be used to cover wounds and provide controlled drug release over time, and is described in the Journal of Vacuum Science & Technology B.

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Researchers from Penn compare a lymphoma-dose regimen of rituximab to a rheumatoid arthritis regimen for the treatment of pemphigus.

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The ADA’s recent updates were developed with expert panel representation from the AAE and provide guidance on when antibiotics should be used in dental treatment.

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Research presented at the 2019 ACR/ARP Annual Meeting found that a six-week treatment with low-dose oral prednisolone substantially improves pain and decreases signs of inflammation in patients with painful hand osteoarthritis.

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A new study found that very few serious infections were seen in children born to mothers with chronic inflammatory diseases who used non-TNFi biologics or tofacitinib during pregnancy compared to children not exposed to these drugs and children exposed to TNFi biologics in utero. These findings are being presented this week at the 2019 ACR/ARP Annual Meeting (Abstract #1901).

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New research findings presented at the 2019 ACR/ARP Annual Meeting found that annual spending on biologic DMARDS (biologics) by U.S. public programs and beneficiaries nearly doubled from 2012 to 2016.

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According to new research findings presented at the 2019 ACR/ARP Annual Meeting, methotrexate did not demonstrate superior efficacy over placebo for pain relief and function evolution at three and 12 months in patients with erosive hand osteoarthritis, but did significantly reduce the progression of joint damage over placebo and seems to facilitate bone remodeling in these patients

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A group of researchers at the University of Michigan Rogel Cancer Center is laying the foundations for a new, “multi-omic” approach that could help determine the drugs to which a particular triple-negative tumor will be most likely to respond based on the totality of its molecular features.

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Tres nuevos estudios siendo presentados en la reunión científica anual de American College of Allergy, Asthma and Immunology (ACAAI) presentan nueva información en alergias a la penicilina.

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Data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that kratom, a popular and widely available product, may cause liver toxicity and severe liver injury.

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Data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found fewer new cases of hepatitis C infection (commonly called HCV), despite very high rates of other sexually-transmitted infections, in HIV-negative men who have sex with men who take pre-exposure prophylaxis (PrEP) treatments.

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Three new studies being presented American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting present new information on penicillin allergy.

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One of the many advertised benefits of vitamin D and fish oil supplements is that they reduce systemic inflammation, which in turn could help prevent certain chronic illnesses. However, a first-of-its-kind study published in AACC’s journal Clinical Chemistry has discovered that these two supplements do not actually reduce inflammation in healthy individuals, a finding that could help consumers make more informed choices about which supplements they decide to take.

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Beta-blockers are often used to treat high blood pressure and other cardiovascular diseases. However, in some patients they can trigger or exacerbate psoriasis, an inflammatory skin disease.

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As the winter months approach, nearly 100 Alaskan sled dogs between the ages of 8 and 13 – former athletes past their glory days – are participating in a $4.2 million study at Cornell University in a quest for one of the holy grails of medicine: how to slow aging.

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The ABA and FAER are co-sponsoring the FAER/ABA Research in Education Grant for a second year to advance the careers and knowledge of physician anesthesiologists interested in key elements of education in anesthesiology.

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The improved technique will help explore genetic diseases and benefit drug development. It could also lead to better, safer weed killers.

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ISPOR, the professional society for health economics and outcomes research—explored the topical issue of the subscription-based model for drug reimbursement this morning during the session, “Subscription-Based Model for Drug Reimbursement: A Fad or the Future?, at ISPOR Europe 2019.

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Northern Arizona University professor O'neil Guthrie is testing a drug designed to help the body's natural ability to repair DNA to determine whether it can help repair cells damaged by noise and help prevent hearing loss.

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A review of 922 prescription medications taken by almost 150 million people over an 11-year period shows that just 10 of these drugs were associated with an increased rate of suicide attempts.

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The U.S. Food and Drug Administration (FDA) has awarded AnaBios an exclusive Indefinite Delivery Indefinite Quantity (IDIQ) contract to employ adult human primary tissues and cardiomyocytes from organ donors to assess drug safety related to cardiac function.

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Using U.S. transplant registry data, clinical researchers at the University of Pittsburgh found that kidney transplants between identical twins have high success rates, but also surprisingly high rates of immunosuppressant use.

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Researchers at Houston Methodist Cancer Center are exploring whether exposure to nature, through either a live garden or virtual reality, can alleviate pain and distress in cancer patients undergoing chemotherapy, possibly reducing the need for prescription narcotics.

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In today's fast-paced digital age, information can become outdated rapidly and people must constantly update their memories. But changing our previous understanding of the news we hear or the products we use isn't always easy, even when holding onto falsities can have serious consequences.

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A medical science tool for individuals to compare the effectiveness of wellness-related treatments

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On October 29, the inter-agency Drug Shortages Task Force led by the U.S. Food and Drug Administration (FDA) issued a report titled “Drug Shortages: Root Causes and Potential Solutions” at the request of Congress. The American Society of Anesthesiologists (ASA) commends the FDA for its analysis of the underlying causes of drug shortages and its recommendations to solve them, many of which align with recommendations offered by ASA and other health care stakeholders last year.

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Join Coriell Life Sciences at APHA 2019, the annual meeting and expo of the American Public Health Association, where the company will present its latest precision public health findings at the Genomics Forum on November 5 at 10:30 a.m. The APHA Annual Meeting, one of the nation’s most influential public health events, will be held November 2-6 in Philadelphia, PA.

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Selecting the most effective molecules for drug delivery is often a trial-and-error process, but Cornell engineers are providing some precision thanks to a technique that reveals the performance of those molecules inside living cells.

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An international team of researchers has used nanoparticles to deliver a drug—one that previously failed in clinical trials for pain—into specific compartments of nerve cells, dramatically increasing its ability to treat pain in mice and rats. The findings are published Nov. 4 in Nature Nanotechnology.

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ISPOR, the professional society for health economics and outcomes research—explored the issue of drug pricing in the session, “Time for Change? Has the Time Come for the Pharma Industry to Accept Modest Prices?.”

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ISPOR, the professional society for health economics and outcomes research—explored the potential of digital health technologies to address key health-related challenges and how to best evaluate these technologies as the field evolves.

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MeriCal, the largest supplier of store brand probiotics, announced today that it has completed and launched the first USP Verified probiotic supplement.

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Conotoxins are bioactive peptides found in the venom that marine cone snails produce for prey capture and defense. They are used as pharmacological tools to study pain signalling and have the potential to become a new class of analgesics. To date, more than 10,000 conotoxin sequences have been discovered.

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The RCSB Protein Data Bank headquartered at Rutgers University–New Brunswick has been awarded $34.5 million in grants over five years from three U.S. government agencies. The funding – an approximately 5 percent increase over the previous five-year period – covers ongoing operations and will expand the reach of the world’s only open-access, digital data resource for the 3D biomolecular structures of life.

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Half of older Americans got help from the infection-fighting power of antibiotics in the past two years, a new poll finds, but a sizable minority didn’t follow the instructions on their pill bottle. And one in five say that in the past, they’ve engaged in a risky practice: taking leftover antibiotics without checking with a medical professional.

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ISPOR, the professional society for health economics and outcomes research—examined real-world evidence studies and the importance of transparency in a number of sessions at ISPOR Europe 2019 in Copenhagen, Denmark.

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Researchers have transplanted engineered pancreatic beta cells into diabetic mice, then caused the cells to produce more than two to three times the typical level of insulin by exposing them to light. The light-switchable cells are designed to compensate for the lower insulin production or reduced insulin response found in diabetic individuals.

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Keith Chan of UAlbany's School of Social Welfare, found that among girls ages 12-17, the misuse of opioids greatly increases the chance of having a major depressive episode.

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Gamers designing proteins, raw food changing the gut, and a toxin-absorbing MOF

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A phase three clinical trial that UT Southwestern participated in determined that a three-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease.

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Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state’s stem cell agency.

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Physicians who received gifts from pharmaceutical companies related to opioid medications were more likely to prescribe opioids to their patients in the following year, according to a new analysis.

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The AHA, ASA, ASCO, ASHP, and ISMP announced their strong support for the Mitigating Emergency Drug Shortages (MEDS) Act, introduced today by Senators Susan Collins (R-ME) and Tina Smith (D-MN).

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More than 30 million people in the United States wrongly believe they are allergic to penicillin.

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A study led by experts at Cincinnati Children's reports new details about a rare lung complication affecting children with systemic JIA. The complications appear related to how some patients react to treatments called "biologics."

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Researchers from the National University of Singapore have developed a method to give more control to optogenetics, by using specially designed nanoparticles and nanoclusters (dubbed ‘superballs’). These nanoparticles and superballs can emit different colours of light when excited by lasers at different wavelengths. These different colours of light can then be used to trigger specific biological processes.

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Spending an hour in talk therapy with a trained counselor costs much more, and takes more time, than swallowing an inexpensive antidepressant pill. But for people with a new diagnosis of major depression, the costs and benefits of the two approaches end up being equal after five years, a new study shows.

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With the increasing rate of multi-drug resistance, it is fundamental to identify new antibiotics. In this study, researchers found the synthesis of the vitamin biotin is integral for the growth of drug-resistant bacteria in human plasma. They were able to treat drug-resistant infections by inhibiting biotin synthesis in an infection mimicking human conditions. By inhibiting biotin synthesis, they have the potential to produce a novel class of antibiotics.