Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature Genetics, is a first step in finding a potential therapeutic strategy for this disorder, and it increases the number of genes known to be associated with conditions that affect how the brain functions.
Researchers at Washington University School of Medicine in St. Louis have shown in preclinical studies conducted in mice and human cells that a type immunotherapy based on natural killer cells could be effective against solid tumors, starting with melanoma, a type of skin cancer that can be deadly if not caught early.
个体化医疗的创举主要专注于治疗罕见疾病或癌症。很少有人尝试对非传染性慢性疾病进行个体化治疗，例如肥胖症 — 这是一种慢性复发疾病，也是诱发2型糖尿病、脂肪肝病、心血管疾病和癌症的主要病因。有许多肥胖症干预的措施，例如饮食、辅助设备、手术和药物。然而，人们对这些肥胖症干预措施的反应预测因素知之甚少。
A decade-long study of distal radius fracture in older adults revealed that personalized medicine catering to a patient’s individual needs and environment, not age or X-rays, should guide treatment options. The federally funded study is the most collaborative, intense effort to try and answer a 200-year puzzle about how to treat one of the most common fractures in older adults.
UCLA Health will receive a $4.8 million grant from The National Institutes of Health to develop methods that will improve genetic risk estimates – polygenic risk scores – for specific diseases in people from diverse populations and mixed ancestries.
Scientists use engineered protein coating that binds to receptors on the surface of corneal cells to improve drug uptake.
The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical CYP2D6 assays, promote standardization of testing across different laboratories and improve patient care. The manuscript, “Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and European Society for Pharmacogenomics and Personalized Therapy,” was released online ahead of publication in The Journal of Molecular Diagnostics.
A study conducted by researchers at the Ludwig Center at Harvard has demonstrated how a drug screening method known as dynamic BH3 profiling can be used to quickly identify potentially effective combinations of existing drugs for personalized cancer therapy.
The June edition of SLAS Technology is a Special Issue entitled, “Emerging Trends in 3D Cell Culture: High-Throughput Screening, Disease Modeling and Translational Medicine.” Free online access to the articles in this collection is courtesy of Corning Life Sciences, the issue’s sponsor.
Digital twins enable customized medical therapies. Empa researchers have now modeled several hundred such avatars based on real people and treated them experimentally. For the first time, the digital twins received feedback from real patients.
To improve the development of new saliva-based diagnostic tests and personalized medicine, the National Institute of Dental and Craniofacial Research (NIDCR) has supported the development of the Human Salivary Proteome Wiki, the first public platform that catalogs and curates data on each of the thousands of proteins within our saliva.
To lower hospital readmission rates for patients with chronic obstructive pulmonary disease (COPD), University at Buffalo pharmacy researcher David Jacobs has received a $962,000 award from the National Heart, Lung, and Blood Institute to develop a real-time readmission risk prediction algorithm.
RNA-based drugs may change the standard of care for many diseases, making personalized medicine a reality. So far these cost-effective, easy-to-manufacture drugs haven’t been very useful in treating brain tumors and other brain disease. But a team of researchers at Georgia Tech and Emory University has shown that a combination of ultrasound and RNA-loaded nanoparticles can temporarily open the protective blood-brain barrier, allowing the delivery of potent medicine to brain tumors.
St. Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology—identifying the genetic ‘switches’ that regulate gene expression.
The American Thyroid Association (ATA) celebrates the recipients of the Women Advancing Thyroid Research Award. This award recognizes and honors the work of young women that are leading outstanding thyroid research.
In a recent perspective article, pathologists outline how the immunome — all of the genes collectively expressed by an individual's immune cells — holds the potential to provide researchers and physicians with unprecedented insight into an individual's health. Collecting that information from large numbers of patients could one day facilitate diagnostics via a near-universal blood test and pave the way to targeted therapies for a wide variety of conditions.
To share important information related to breast cancer, we have compiled some of the latest research news related to breast cancer from top research institutions around the world.
Scientific studies rarely focus on long non-coding RNA molecules (lncRNAs), even though they potentially regulate several diseases.
Individuals with metastatic breast cancer could soon have access to personalized, supplemental supportive care through their smart speaker, thanks to new research at Penn State.
Moores Cancer Center at UC San Diego Health is among the few clinical trial sites in the U.S. for the Pancreatic Cancer Action Network’s (PanCAN) newly created Precision Promise, the first large-scale precision medicine trial designed to transform outcomes for patients with pancreatic cancer.
A new grant is helping McMaster University engineers and a Toronto precision-medicine diagnostics company to get infection-testing technology to market while generating opportunities for students.
The U.S. Food and Drug Administration recently approved a new CAR-T therapy called idecabtagene vicleucel (ide-cel), or Abecma. It’s the first personalized cell therapy to treat patients with multiple myeloma no longer responsive to all standard previous types of therapy. This new therapy was assessed in the pioneering phase II clinical KarMMA trial, at Hackensack Meridian John Theurer Cancer Center at Hackensack Meridian Hackensack University Medical Center.
A personalized cancer vaccine developed with the help of a Mount Sinai computational platform raised no safety concerns and showed potential benefit in patients with different cancers, including lung and bladder, that have a high risk of recurrence, according to results from an investigator-initiated phase I clinical trial presented during the virtual American Association for Cancer Research (AACR) Annual Meeting 2021, held April 10-15.
Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders and offers a promising blood test aimed at a precision-medicine approach to treatment.
In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).
A University of Washington-led team has developed a method that uses the camera on a person’s smartphone or computer to take their pulse and breathing rate from a real-time video of their face.
A collaborative team centered in the University of California, Irvine (UCI) and including Children’s Hospital Orange County (CHOC) and Chapman University (CU) has been awarded a three-year grant totaling in excess of $2.3 million, to address the health impacts of adverse childhood experiences (ACEs) using precision medicine.
New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease
Personalized medicine research for aggressive abdominal cancers receives a boost with a new $2.5 million grant award from the National Cancer Institute that highlights research efforts by the Wake Forest Organoid Research Center (WFORCE).
تكتسب المعركة العالمية ضد داء السل بعض الأدوات القوية. الطب الدقيق — المُستخدم بالفعل لتخصيص تشخيص الأمراض غير المعدية وعلاجها، مثل: السرطان — وتقنيات الرعاية الصحية، مثل: الطب عن بُعد، لديهما القدرة على تطوير الوقاية والعلاج من داء السل، كما يقول زلالم تمسجين، دكتور الطب، خبير الأمراض المعدية والمدير الطبي لمركز داء السل التابع لمايو كلينك.
A luta global contra a tuberculose está ganhando algumas ferramentas poderosas. A medicina de precisão — já usada para personalizar o diagnóstico e o tratamento de doenças não transmissíveis, como o câncer — e as tecnologias de saúde, como a telemedicina, têm potencial para avançar na prevenção e no tratamento da tuberculose, afirma Zelalem Temesgen, M.D.
全球抗击肺结核的努力获得了医疗技术的强大助力。精准医学已经用于非传染性疾病（例如癌症）的诊断和治疗，它和远程医学等医疗技术有可能促进结核病的预防和治疗，妙佑医疗国际 (Mayo Clinic) 肺结核中心的传染病专家和医学主任 Zelalem Temesgen 医学博士 说。
La lucha mundial contra la tuberculosis ahora cuenta con algunos instrumentos poderosos. La medicina de precisión que ya se aplica para personalizar el diagnóstico y el tratamiento de enfermedades no contagiosas, como el cáncer, junto a las tecnologías para la atención de la salud, como la telemedicina, tienen la capacidad de avanzar la prevención y el tratamiento de la tuberculosis, dice el Dr. Zelalem Temesgen, experto en enfermedades infecciosas y director médico del Centro para Tuberculosis en Mayo Clinic.
The global fight against tuberculosis is gaining some powerful tools. Precision medicine — already used to personalize diagnosis and treatment of noncommunicable diseases such as cancer — and health care technologies such as telemedicine have the potential to advance the prevention and treatment of tuberculosis, says Zelalem Temesgen, M.D., an infectious diseases expert and medical director of the Mayo Clinic Center for Tuberculosis.
Treatment of hypothyroidism, which results from an underactive thyroid gland, should be individualized and consideration should be given to alternatives to the first-line therapy, including desiccated thyroid extract and combination therapy to replace the body’s two main thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Results of their new randomized clinical study are being presented at ENDO 2021, the Endocrine Society’s annual meeting.
Low representation of minority groups in public genomic databases may affect therapy selection for Black patients with cancer, according to new Mayo Clinic research published in npj Precision Oncology. The researchers investigated the use of genomic databases and found that tumor mutation burden was significantly inflated in Black patients compared to White patients. As a result of the study, clinicians who are using public genomic databases need to be aware of the potential for inflated tumor mutation burden values and how that may affect therapy selection and outcomes, especially for patients from underrepresented groups.
Corrona, LLC, a leading provider of real-world evidence solutions, announced today that it has changed its name to CorEvitas [kohr-eh'-vi-tahs].
Genetic science is a game-changer for medication safety and healthcare overall, and Coriell Life Sciences is leading the way in unlocking its full potential through precision medicine.
Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML) – called NPM1 – that could help predict survival and improve treatment response for patients whose leukemic cells bear the mutation.
As yet there is no prescription drug to cure mild cognitive impairment (MCI), often a harbinger of Alzheimer's disease. Medical research journals reveal curcumin can sometimes bolster cognition. It merits a try.
Thunderbird School of Global Management announces the first of two prestigious Hoffmann Fellowships appointed in collaboration with the World Economic Forum for post-doctoral research and policy innovation at the intersection of society, science and technology.
An international team of researchers led by Michigan State University’s Morteza Mahmoudi has developed a new method to better understand how nanomedicines — emerging diagnostics and therapies that are very small yet very intricate — interact with patients’ biomolecules.
A phase 2 clinical trial providing personalized treatments based on the genetic profile of metastatic tumors in gastroesophageal cancers has found that using customized treatment approaches, and adapting them over time as tumors become resistant, led to higher rates of survival compared to historical controls.
While decades of research have resulted in substantial improvements in surviving cancer, a key challenge remains in identifying new drugs that improve outcomes for patients. In APL Bioengineering, researchers suggest a major hurdle is the paucity of models for cancer research that accurately represent patient tumors. They provide a perspective on strategies using models from individual patients and where the field needs to go in terms of research in animal systems and in culture systems.
Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell.
Today, the Pulmonary Fibrosis Foundation (PFF) announced enrollment of the first patient in PRECISIONS (Prospective tReatment EffiCacy in IPF uSIng genOtype for Nac Selection) clinical trial. This is the first clinical trial to apply the principles of precision medicine to the treatment of patients with idiopathic pulmonary fibrosis (IPF).
In a study published today in the journal Science Advances, a team from Roswell Park details a method to measure the abundance of cancer-related early changes to skin tissue long before the damage becomes visible to the eye.
The Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University and Boehringer Ingelheim, one of the world’s largest pharmaceutical companies will leverage the power of CCIPD’s image computing AI solutions to identify patterns and links between cellular response and underlying molecular drivers, with the goal of advancing therapeutics for diseases with no satisfactory treatment option.
ALCEDIAG, one of 3 finalists for the “Disruptive Technology Award” at the annual AACC meeting 2020, will be holding a press conference to announce a game-changing technology and diagnostic tool for precision medicine in psychiatry: EDIT-BTM, the very first blood test for a high-performance differential diagnosis of unipolar depression and bipolar disorder.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right