The Neuro (Montreal Neurological Institute and Hospital) will lead an open science partnership to develop precision drugs for amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD).
The ability to hear depends on proteins to reach the outer membrane of sensory cells in the inner ear. But in certain types of hereditary hearing loss, mutations in the protein prevent it from reaching these membranes.
Researchers used neutron scattering at ORNL’s Spallation Neutron Source to investigate the response properties of polymer gels commonly used in products like cosmetics, adhesives, and paints. A better understanding of their behaviors will lead to improved products and potential new medical applications for drug delivery.
A UCLA-led research team has pinpointed a three-drug combination that could prove to be an effective new therapy for people with a specific type of advanced melanoma.
Irvine, Calif., June 5, 2019 — A nanotechnology treatment derived from bone marrow stem cells has reversed multiple sclerosis symptoms in mice and could eventually be used to help humans, according to a new study led by University of California, Irvine researchers. “Until now, stem cell therapies for autoimmune and neurodegenerative diseases have produced mixed results in clinical trials, partly because we don’t know how the treatments work,” said corresponding author Weian Zhao, an associate professor of pharmaceutical sciences and biomedical engineering who is affiliated with the Sue & Bill Gross Stem Cell Research Center.
The introduction of the Developing an Innovative Strategy for Antimicrobial Resistant Microorganisms -- DISARM -- Act -- by United States Senators Johnny Isakson (R-GA) and Bob Casey (D-PA) Tuesday represents an essential step toward addressing the growing threat of infections that are increasingly resistant to existing treatments. By improving critical Medicare reimbursement for antibiotics and promoting their appropriate use, the legislation has the potential to stabilize the antibiotics market, spur the development of new infection-fighting drugs, and preserve the effectiveness of existing medicines.
Columbia University and Deerfield Management, a healthcare investment firm, today announced the creation of a major research and development alliance. The collaboration is intended to advance the translation of biomedical discoveries into transformative treatments for improved quality of life and cures for disease.
When it comes to buying probiotics, most product labels do not give consumers enough information to make an informed decision, according to a research team led by Georgetown University Medical Center.
Preschool children with community-acquired pneumonia often receive unnecessary tests and treatment at outpatient clinics and emergency departments, according to a nationally representative study led by Todd Florin, MD, MSCE, from Ann & Robert H. Lurie Children’s Hospital of Chicago.
Biochemists at Université de Montreal discover a new mechanism to better predict whether an anti-cancer therapy will work.
Advancement in the area of value assessment in health care took the spotlight in several discussions featured recently at the national conference of the 2019 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) in New Orleans.
A previously unknown autoimmune muscle disease involving sudden onset of debilitating muscle pain and weakness has been identified by researchers at Washington University School of Medicine in St. Louis. The syndrome easily could be mistaken for other muscle diseases that require different treatment, so the findings are expected to help physicians treat patients appropriately, the researchers said.
A study conducted by a team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed a close association between liposarcoma (LPS), a type of cancer that develops from fat cells, and the bromodomain and extraterminal (BET) protein family.
A new study found that 81% of antibiotics prescribed by dentists to prevent infections prior to dental visits are unnecessary.
New research published in Anesthesiology reports that after an Opioid Safety Initiative was implemented at the Veterans Health Administration, patients undergoing knee replacement surgery were prescribed significantly less opioids with minimal impact on patients’ reported pain scores.
Ibrutinib and venetoclax, two FDA-approved drugs for treating chronic lymphocytic leukemia (CLL), have been shown to be effective when given together for high-risk and older patients with the disease, according to a study at The University of Texas MD Anderson Cancer Center.
An international research collaboration that includes the University of Arkansas for Medical Sciences (UAMS) has discovered that aging in nematodes (worms) can be slowed and even reversed by a number of Food and Drug Administration (FDA)-approved drugs, findings that have the potential to extend human lifespan. The study findings are published in Scientific Reports.
A new study of patients reading the visit notes their clinicians write, reports positive effects on their use of prescription medications
James Wilson, MD, PhD, director of Penn’s Gene Therapy Program and Orphan Disease Center, and a professor of Medicine and Pediatrics in the Perelman School of Medicine at the University of Pennsylvania, recalls being struck by the devastating toll of rare diseases as a young physician in the 1980s. He set out on a path to correct the genes that cause these conditions, including spinal muscle atrophy (SMA), the most common inherited fatal disease in infants. Today, Wilson and his team are celebrating a major milestone in the field: approval by the U.S. Food and Drug Administration (FDA) of a gene therapy known as Zolgensma for SMA. The therapy is based on a delivery vehicle that his team discovered and developed over the past decade as part of a wide-ranging portfolio of research to advance gene therapy.
Dr. Sanjay Gupta, CNN’s chief medical correspondent, told graduates of Albert Einstein College of Medicine to embrace fear, savor opportunities to do the impossible, and practice empathy as they embark on what he called “the best job in the world.”
Researchers from University of Pennsylvania find adding bevacizumab to carboplatin-pemetrexed was effective in treating non-squamous non-small cell lung cancer, in new study published in JNCCN—Journal of the National Comprehensive Cancer Network.
ISPOR, the professional society for health economics and outcomes research, held its final plenary of the ISPOR 2019 annual conference with, “Is Healthcare Affordability Driving a Need to Revolutionize Drug Pricing?”
ISPOR, the professional society for health economics and outcomes research, explored the possibility of health technology assessment in the United States this morning at its ISPOR 2019.
A new study advocates for exercise as a fundamental treatment and intervention method within inpatient psychiatric facilities.
New drug also may increase effectiveness of oral chemotherapy for these tumors, known for their resistance to treatment.
Production of actinium-227 ramps up for use in a drug to fight prostate cancer that has spread to bone.
The June cover of SLAS Discovery features cover article “A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction,” by Timothy M. Willson, Ph.D., a noted University of North Carolina Eshelman School of Pharmacy (Chapel Hill, NC, USA) Research Professor and Chief Scientific Officer for the Structural Genomics Consortium (SGC) (Oxford, UK).
The June issue of SLAS Technology features the article, “Next Generation Compound Delivery to Support Miniaturized Biology,” which focuses on the challenges of changing the established screening paradigm to support the needs of modern drug discovery.
Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout the body—but a recent study shows what happens next. In results published in Cell, researchers outline the timeline of events, including precisely when and how different parts of a GPCR interacts with its G protein signaling partners. The findings provide new insights into the fundamental mechanisms of drug-induced signaling in cells, including ways to identify the most critical portions of GPCRs for targeting development of novel therapeutics.
Patients with severe eosinophilic asthma, who participated in three different Phase 3 trials of benralizumab (brand name Fasenra) and then enrolled in a long-term trial of the drug’s efficacy and safety, continued to experience fewer exacerbations and improved pulmonary function and quality of life
Those same antibiotics driving antibiotic resistance could also help defeat it if used with the right strategy. Making it work would require companion health strategies like staying home from work when carrying resistant bacteria.
”There's a lot of merit in bringing medicines to people who can't reach them themselves, but it's sort of putting a bandaid on the situation and I realized that only through scientific discovery will we really make huge changes that impact large populations of people. So that's why I started doing research and global health, specifically dengue virus and Zika virus.” —Dr. Melanie McCauley
Progress in a large-scale effort by the PhRMA Foundation to improve health care value-assessment will be highlighted during the national conference of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) next week in New Orleans. To date, the Foundation has invested $2.8 million to support a variety of value-assessment research efforts, including the establishment of four value-assessment Centers of Excellence.
Strict policies traditionally embraced by Asian nations to discourage illicit drug use are beginning to change
ASA today presented Joshua Chance, M.D., president of the Arkansas Society of Anesthesiologists, with the 2019 Bertram W. Coffer, M.D., Excellence in Government award, given in recognition of exemplary contributions to the medical specialty of anesthesiology, its practitioners and patients.
Surgical patients receiving the opioid tramadol have a somewhat higher risk of prolonged use than those receiving other common opioids, new Mayo Clinic research finds. However, the Drug Enforcement Administration (DEA) classifies tramadol as a Schedule IV controlled substance, meaning it's considered to have a lower risk of addiction and abuse than Schedule II opioids, such as oxycodone and hydrocodone.
ASA today announced Masimo, a maker of innovative, noninvasive patient monitoring technologies, medical devices and sensors, has again signed on as an ASA Industry Supporter to support the work and partner with ASA, and its more than 53,000 physician anesthesiologists members.
Researchers at The University of Chicago have demonstrated that the type of bacteria living in the gut can influence the development of Alzheimer’s disease symptoms in mice. The study, which will be published May 16 in the Journal of Experimental Medicine, shows that, by altering the gut microbiome, long-term antibiotic treatment reduces inflammation and slows the growth of amyloid plaques in the brains of male mice, though the same treatment has no effect on female animals.
ISPOR—the professional society for health economics and outcomes research (HEOR)—released the final program and speakers for its upcoming ISPOR 2019 annual conference scheduled for May 18-22, 2019 in New Orleans, LA, USA.
As states crack down on doctor and pharmacy “shopping” by people who misuse opioids, a new study reveals how often those individuals may still be able to find opioids to misuse in their family medicine cabinets. For every 200 patients prescribed opioids, one had a family member whose opioid-misuse problem led them to seek the drugs from multiple prescribers and multiple pharmacies.
In mouse models and prostate cancer cell lines, researchers at the University of Michigan have demonstrated the preliminary effectiveness of a new set of compounds that offer a potential advance in the treatment of metastatic castration-resistant prostate cancer — one that appears to avoid many of the usual mechanisms of treatment resistance.
A new study by researchers at the Johns Hopkins Bloomberg School of Public Health found that prices for brand-name prescription drugs averaged 3.2 to 4.1 times higher in the U.S. when compared with prices in the United Kingdom, Japan and the Canadian province of Ontario. The study also found that the longer the brand-name prescription drug was on the market, the greater the price differential.
The Operation Supplement Safety (opss.org) website, established by the Consortium for Health and Military Performance (CHAMP), a Department of Defense (DoD) Center of Excellence at the Uniformed Services University of the Health Sciences, is releasing a new version with additional resources and enhanced features to promote awareness among DoD personnel and their family members about dietary supplement safety.
The Global Health Impact Index, developed by faculty at Binghamton University, State University of New York to rank pharmaceutical companies based on their drugs’ impact on global health, is launching a new, more-robust model that addresses even more diseases worldwide.
In experiments with pregnant mice infected with the Zika virus, Johns Hopkins Medicine researchers report they have successfully used a long-standing immunosuppressive drug to diminish the rate of fetal deaths and birth defects in the mice’s offspring.
The drug eculizumab, a synthetic antibody that inhibits the inflammatory response, significantly reduced the risk of relapse with neuromyelitis optica spectrum disorder (NMOSD). Mayo Clinic researchers and international collaborators published their findings in the New England Journal of Medicine.
A study of a blood pressure drug does not show any benefit for people with Parkinson’s disease, according to findings released today that will be presented at the American Academy of Neurology’s 71st Annual Meeting in Philadelphia, May 4 to 10, 2019. The drug isradipine had shown promise in small, early studies and hopes were high that this could be the first drug to slow the progression of the disease.
Baylor Scott & White Health now offers a new, more convenient prescription pickup option for patients. Baylor Scott & White Pharmacy kiosks, which are located on medical centers throughout the healthcare system’s service area, are now being installed offsite to make filling prescriptions easier for more patients.
Researchers’ work shows how curiosity, creativity drive science and illustrates how a passion for discovery enriches knowledge
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