Feature Channels: Blood

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A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for April 2023.

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When Russia’s War on Ukraine began, individuals around the world mobilized to support the Ukrainian people. Among those offering help is a group from Michigan Medicine’s Max Harry Weil Institute for Critical Care Research and Innovation.

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A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach could also power the development of advanced cell therapies for cancers and other diseases, according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

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New research suggests that even mild cases of COVID-19 can have long-term detrimental effects on cardiovascular health. The study was the first to compare pre and post COVID-infection levels of arterial stiffness; a marker associated with the ageing and function of our arteries.

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The FLASH (FlowTriever All-Comer Registry for Patient Safety and Hemodynamics) study results were published recently in EuroIntervention, the journal of the European Association of Percutaneous Coronary Interventions, with interim results published earlier in 2022 in Catheterization & Cardiovascular Interventions.

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In Physics of Fluids, researchers model the behavior of blood drops during secondary atomization to examine how the phenomenon affects a crime scene. The team examined different starting droplet sizes, confirming their model with experiments. They found the effect of secondary atomization was significant and predictable: The smaller droplets were easier to sweep up by the firearm’s gases and turn around toward the victim. This discovery could explain how a short-range shooter might stay clean from blood stains.

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A federal grant to study treatment resistance in certain lymphoma patients, new research showing rogue Natural Killer cells are present in an aggressive breast cancer and likely promote tumor progression, a National Cancer Institute grant to study the role opioids may play in breast cancer, and leading blood cancer experts worldwide presented research advances at the recent Miami Leukemia Symposium are highlighted in this month’s tip sheet from Sylvester Comprehensive Cancer Center.

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Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.

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New research out of the University of Wisconsin-La Crosse finds that passive stretching before a run protected the vascular function of participants.

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Indiana University Melvin and Bren Simon Comprehensive Cancer Center served as the lead site for a promising first-in-human clinical trial for patients with relapsed multiple myeloma. Patients treated with higher doses of the immunotherapy called REGN5459 resulted in a 90.5 percent overall response rate.

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Researchers have made huge strides in ensuring that red blood cell substitutes – or artificial blood – are able to work safely and effectively when transfused into the bloodstream.

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Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.

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An international phase 3 clinical trial led by physicians at Washington University School of Medicine in St. Louis has shown that the investigational drug motixafortide — when combined with the standard therapy for mobilizing stem cells — significantly increases the number of stem cells that can be harvested, compared with treatment with the standard agent alone.

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Patients with sickle cell disease (SCD) who undergo total knee replacement are at higher risk for complications than non-SCD patients, according to a large-scale, retrospective study by researchers from UT Southwestern Medical Center and the University of Calgary. The study was published in Archives of Orthopaedic and Trauma Surgery.

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Mayo Clinic has made significant strides biomanufacturing early-stage therapeutics. The focus is on new medicines derived from the human body, called biotherapeutics, which are shaping the future of medicine.

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An international coalition of biomedical researchers co-led by Alexander Bick, MD, PhD, at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer. The technique, called PACER, led to the identification of a gene that, when activated, drives clonal expansion.

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Below are some of the latest headlines in the new Avian Flu channel on Newswise.

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The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. This special edition features presentations by MD Anderson researchers at the American Association for Cancer Research (AACR) Annual Meeting 2023.

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St. Jude Children’s Research Hospital scientists developed a combination therapy for a leukemia subtype harboring rearrangements in the KMT2A gene. The approach overcomes the cancer’s drug resistance, without adding toxicity. The study appears in Proceedings of the National Academy of Science.

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A new analysis led by Alex K. Gertner, MD, PhD, psychiatry resident at UNC Hospitals, has added further evidence that the new model is effective.

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New research from the UC Davis School of Medicine shows high blood pressure in early adulthood is associated with worse brain health in late life — especially for men. The results suggest that treating hypertension in young and middle-aged adults may help prevent dementia and Alzheimer’s disease.

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Read about cutting-edge cancer research centered around elephant genes, a new clinical trial, and grants to study vaccination hesitance in the Mountain West as well as chronic lymphocytic leukemia.

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Complications after a minimally invasive balloon pulmonary angioplasty have decreased substantially over the last decade for patients with high blood pressure in their pulmonary arteries caused by chronic blood clots, known as CTEPH. The procedure, which is offered for patients who are not candidates for surgery, involves inflating a balloon inside of diseased lung arteries to break up clots and restore blood flow to the lungs.

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The April issue of The American Journal of Gastroenterology highlights new clinical science, including an examination of changes in lifestyle habits and risk of colorectal cancer

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In a new study looking at the long-term effects of hospitalized patients who have acute kidney injury (AKI), a sudden but temporary loss of kidney function, Johns Hopkins Medicine researchers found that higher levels of certain biomarkers in urine and blood can predict a patient’s risk of developing chronic kidney disease (CKD).

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High blood pressure in children is not uncommon, and research shows it may lead to high blood pressure in adulthood, as well as problems with the heart, blood vessels and kidneys.

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Researchers at Boston University, USA report that the flow of cerebrospinal fluid in the brain is linked to waking brain activity.

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University of Wisconsin–Madison researchers have developed a new method for targeting tumors with cancer drugs by exploiting the clotting propensity of blood platelets.The new approach, first described March 29 in the journal Science Advances, adds to a growing set of innovative drug delivery techniques under development in the lab of Quanyin Hu, a professor in the UW–Madison School of Pharmacy.

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El Dr. Sikander Ailawadhi, hematólogo y oncólogo del Centro Oncológico Integral de Mayo Clinic, comparte detalles sobre los nuevos avances en la investigación que conducen a mejores resultados en pacientes que padecen mieloma múltiple.

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O Dr. Sikander Ailawadhi, hematologista/oncologista do Centro de Câncer da Mayo Clinic, compartilha os detalhes sobre os novos avanços na pesquisa que levou a melhores resultados para pacientes com mieloma múltiplo.

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From septic shock to sticker shock. Keep up with this ever-growing, changing sector. Below are some of the latest stories on healthcare on Newswise.

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A new study found that people who are currently suffering or face a high risk of post-traumatic stress disorder show particular patterns in four biomarkers measurable with a simple blood test.

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Scientists seeking a way to eliminate an adverse reaction to treatments for acute lymphocytic leukemia, a common childhood cancer, have found what they believe to be an early warning indicator. Mouse studies conducted by Rutgers researchers as part of a larger scientific team are pointing to vitamin A levels as a signal that a patient may or may not be vulnerable to a dangerous toxicity.

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To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men and women with HIV on long-term suppressive therapy, a team led by Johns Hopkins Medicine scientists reports new evidence that one such stable reservoir of HIV genomes can be found in circulating white blood cells called monocytes.

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When our blood vessels are injured by cuts, abrasions, or bruises, it is vital that the bleeding is stopped, and the wound is sealed.