Commercial insurance medical policies that do not cover treatment with proton therapy can make it difficult for patients to participate in randomized clinical trials funded by the NCI, part of the National Institutes of Health, that are evaluating the therapy.
Patients who suffer from Aspirin Exacerbated Respiratory Disease (AERD) often experience an additional allergic reaction when drinking alcohol, including nasal congestion, wheezing, and a runny nose. Now a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania finds a common treatment for AERD – aspirin desensitization – can also help alleviate the alcohol-induced symptoms of the condition.
A poorly understood mutation in the brain cancer glioblastoma (GBM) is now being implicated for the first time as the driver of rare but deadlier cases of the disease, a team of researchers from the Perelman School of Medicine at the University of Pennsylvania and the Ludwig Institute for Cancer Research reported this week in Cancer Cell.
Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, the first demonstration of a clinically relevant reduction of gene expression in a large animal model using genome editing. This finding could lead to a possible new approach for treating heart disease patients who do not tolerate PCSK9 inhibitors—drugs that are commonly used to combat high cholesterol.
Wolters Kluwer Health announced today that its Lippincott Professional Development portfolio has received the American Nurses Credentialing Center’s (ANCC) 2018 Accreditation Premier Program Award for the second consecutive year. The award recognizes accredited organizations that excel in providing high-quality nursing education activities and deliver excellence in leadership, innovation, and quality outcomes to meet the needs of learners.
Brian C. Capell, MD, PhD, an assistant professor of Dermatology in the Perelman School of Medicine at the University of Pennsylvania, a core faculty member of the Penn Epigenetics Institute, and a member of the Abramson Cancer Center, has been awarded a prestigious Damon Runyon Clinical Investigator Award for 2018.
As the roles for telemedicine, robotics, and even augmented reality in medicine expand, some researchers are focusing on making sure conversation and storytelling - tools and skills that have been around since the beginning of time - still play a central role in health care.
Symptoms of depression and anxiety are present in about one-third of patients with heart failure – and these patients are at higher risk of progressive heart disease and other adverse outcomes, according to a review and update in the July/August issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Especially at longer follow-up times, overweight and obesity are associated with chronic disease risks for survivors of moderate to severe traumatic brain injury (TBI), reports a study in the July/August issue of the Journal of Head Trauma Rehabilitation (JHTR). The official journal of the Brain Injury Association of America, JHTR is published in the Lippincott portfolio by Wolters Kluwer.
Spine surgeons earn high ratings for their skill and good clinical outcomes on internet review sites – but are more likely to receive negative ratings and comments on factors pertaining to clinic staff, billing, and wait times, reports a landmark study in Spine. The journal is published in the Lippincott portfolio by Wolters Kluwer.
The innate NK-cell response requires a rather carefully choreographed interaction of three cell types.
Nearly all major neurodegenerative diseases are defined by the presence of one of four proteins that have gone rogue. As such, investigational drugs aimed at preventing or slowing the disease often hone in on just one of these proteins. However, targeting multiple proteins at once may be the real key, according to a recent Penn Medicine study.
Stimulating the prefrontal cortex, the part of the brain responsible for controlling complex ideas and behaviors, can reduce a person’s intention to commit a violent act by more than 50 percent, according to research from the University of Pennsylvania and Nanyang Technological University.
Ophthalmologists from Wills Eye Hospital are teaming up with Philadelphia Fire Department Officials throughout the big holiday week this week to send the all- important public safety message to always leave fireworks to the professionals and not risk devastating injuries to your eyes, hands or the rest of your body.
Understanding and addressing what patients need from an emergency room encounter could help improve patient care.
Wolters Kluwer Health announced today it will begin publishing the Journal of Bio-X Research under its Lippincott portfolio. The first issue of the Journal of Bio-X Research, the newest open access journal of the Chinese Medical Association (CMA), is available today.
Cryolipolysis is a noninvasive cosmetic procedure that eliminates excess fat by freezing it. But a complication called paradoxical adipose hyperplasia (PAH) –a hardened area of localized fat developing after cryolipolysis – may be more common than previously thought, suggests a paper in the July issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Routine assessment by an endocrinologist and laboratory tests to measure hormone levels aren't necessary in most adolescent boys with gynecomastia (male breast enlargement), concludes a study in the July issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
“Hot” tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to “cold” tumors with fewer T cells, but a clear demonstration of why has eluded cancer biologists—until now. Researchers discovered that whether a tumor is hot or cold is determined by information embedded in the cancer cells themselves, which could help oncologists more precisely tailor treatments to a patient’s unique tumor composition.
To make sure that good ideas to enhance healthcare are not lost due to a lack of resources, a growing number of centers at Penn Medicine organize forums to pitch ideas to improve medical devices and technology, hold annual competitions to fund studies to improve patient care while keeping costs down, and sponsor seed grants for programs focused on patients who need individualized tailoring of their treatment. This last category is where precision medicine comes in, which is designed to enhance care for particular groups of patients, based on their genetic background, patient history, and unique diagnosis.
By educating physicians about unique properties of the olfactory system, Monell scientist Pamela Dalton, PhD, MPH, seeks to increase understanding of stigmas associated with incontinence
For children of lesbian or gay parents, psychological adjustment is about the same as in children of heterosexual parents, reports a study in the Journal of Developmental & Behavioral Pediatrics, the official journal of the Society for Developmental and Behavioral Pediatrics. The journal is published in the Lippincott portfolio by Wolters Kluwer.
The Monell Center, in partnership with the University of Florida Center for Smell and Taste and the Rocky Mountain Taste and Smell Center at the University of Colorado School of Medicine, will host an interdisciplinary two-day conference in November 2018 to establish a roadmap for treatment-focused research on smell and taste disorders. The “Identifying Treatments for Taste and Smell Disorders” meeting will include sessions focused on the science of sensory disorders and their treatment and also on patient education.
For adolescents with symptoms following a concussion, starting physical therapy (PT) earlier – within less than three weeks after the injury – provides outcomes similar to those of later PT, suggests a study in the July issue of The Journal of Neurologic Physical Therapy (JNPT). The journal is published in the Lippincott portfolio by Wolters Kluwer.
As cancers find ways to bypass a new therapy, researchers discover the tumor also develops an Achilles heel that can be hit with a different cancer therapy.
The American College of Surgeons Commission on Cancer (CoC) has granted a three-year accreditation and its highest honor, the Outstanding Achievement Award, to the Abramson Cancer Center at Penn Presbyterian Medical Center.
Protein fragments, called amyloid fibrils, in human semen significantly increase Ebola virus infection and protect the virus against harsh environmental conditions such as heat and dehydration. Follow-up studies from the 2014 epidemic found that men can harbor the virus in their semen for at least 2.5 years, with the potential to transmit the virus sexually during that time. Targeting amyloids in semen may prevent a sexually transmitted spread of the Ebola virus.
Saint Joseph’s University, in partnership with the American Osteopathic Association (AOA), has announced a healthcare-focused Executive MBA program designed exclusively for AOA’s physician members.
NCCN convenes summit on providing high-quality cancer care in an evolving policy and tech landscape, featuring FDA Chairman Scott Gottlieb, Co-Chairs of the Congressional Survivors Caucus, Congressmen Mark DeSaulnier and Ted Poe, and new data on the impact of narrow networks on cancer care delivery.
Children with known skin, food and respiratory allergies should be screened for an emerging food allergy called eosinophilic esophagitis (EoE), a painful inflammation of the esophagus. Pediatric allergists who analyzed a very large group of children say that EoE is a later component of the “allergic march”-- in which many children successively develop a series of allergies.
Influenza A hijacks host proteins for viral RNA splicing and blocking these interactions caused replication of the virus to slow, which could point to novel strategies for antiviral therapies.
Black Americans are nearly three times more likely to be killed by police than their white counterparts, with even larger disparities among those who are unarmed. The trend is also harming the mental health of the black community, according to new research published in The Lancet from the Perelman School of Medicine at the University of Pennsylvania and the Boston University School of Public Health.
The key to better treatments for brain injuries and disease may lie in the molecules charged with preventing the clumping of specific proteins associated with cognitive decline and other neurological problems, researchers from the Penn report in a new study published in Neurobiology of Disease.
In new study in JNCCN - Journal of the National Comprehensive Cancer Network, Netherlands-based researchers found emergency colon cancer surgery was more likely to lead to complications if performed on a weekend, rather than a weekday.
In an article published today in the New England Journal of Medicine, University of Pennsylvania researchers call for modernizing the way Medicare pays for training nurses, and highlight a successful new model of cost-effectively training more advanced practice nurses to practice community-based primary care.
In an effort to improve stroke recognition and reduce life-threatening pre-hospital delays worldwide, researchers at Penn Medicine created a universal stroke awareness program, Stroke 112.
Penn Medicine launched the Penn Center for Neuroaesthetics, which aims to uncover the biological basis of aesthetics. The center will advance the understanding of human nature and preferences with consumer choices, the principles of design, and the appreciation and production of art.
Swarthmore has enhanced its campus navigation system for the blind, among the most sophisticated at colleges and universities in the country.
National Comprehensive Cancer Network releases new patient guidelines for liver, gallbladder, and bile duct (hepatobiliary) cancers, sponsored by the Global Liver Institute.
A pair of recent studies performed by researchers at Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania represents a significant step forward in understanding the role of the brain’s “reward circuit” and certain hallmarks of autism spectrum disorder (ASD), namely difficulty interpreting or engaging in typical social behavior and restricted or repetitive interests or behaviors.
A look at the unique opportunities and challenges doctors face as they join social media
Benjamin A.Garcia, PhD, an expert in quantitative proteomics has been awarded the Biemann Medal by the American Society for Mass Spectrometry (ASMS). The early-career award recognizes significant achievement in basic or applied mass spectrometry. Garcia’s lab has develop
Proteins commonly known as BRCA – short for BReast CAncer susceptibility gene– serve a critical role in cellular DNA repair, but when mutated they allow genetic errors to replicate, facilitating cancer development. If the BRCA repair system is disabled in cancer cells, the cells simply turn to backup repair mechanisms and adapt to alternative repair pathways, a survival mode that also underlies their ability to evade targeted drug therapies.
The concept of non-human beings endowed with intelligence dates back to at least Homer in the late eighth or early seventh century B.C. As society has developed and our ability to tell stories enhanced by technology, the idea of intelligent machines has captured the minds of societies across the globe.
Could being more knowledgeable about finances help to keep you out of the hospital? Older adults with higher financial literacy are at lower risk of being hospitalized, reports a study in the July issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Patient age correlates with response to immunotherapy in melanoma and depleting regulatory T cells in young patients may have a therapeutic potential to enhance response in younger patients, according to research from The Wistar Institute.
One of the iconic ingredients of the Mediterranean diet, which often has been associated with beneficial effects in the prevention of cancer as well as several other disorders, is extra-virgin olive oil. For thousands of years, olive trees were planted on Mediterranean coasts, initially by ancient Greek colonists, followed by several other civilizations and cultures, one generation after the other.
When first learning to drive, young adults with autism spectrum disorder (ASD) have more difficulty with basic driving skills compared to those with typical development (TD), reports a study in the Journal of Developmental & Behavioral Pediatrics, the official journal of the Society for Developmental and Behavioral Pediatrics. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Lab tests demonstrate that a hydrogel could help repair damaged spinal nerves that control breathing, an advance that could eventually be developed into new patient treatment.
Changes in cellular struts called microtubules can affect the stiffness of diseased human heart muscle cells, and reversing these modifications can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure.
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