Feature Channels: Pharmaceuticals

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SAN FRANCISCO – Preliminary data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that people who inject drugs who are infected with the hepatitis C virus have high rates of hepatitis C treatment adherence (completion of their treatment), and sustained virologic response. Based on these findings, researchers conclude these patients should be included in HCV treatment programs.

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SAN FRANCISCO – Preliminary data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that patients treated with immune checkpoint inhibitors rarely develop severe liver toxicity, but the majority of those who do permanently stop this cancer treatment. None of the patients developed liver failure as a result of this treatment.

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SAN FRANCISCO – Data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found the combination of glecaprevir and pibrentasvir is highly effective and well tolerated in patients with chronic hepatitis C virus (commonly called HCV) genotype-1 infections who have prior treatment experience with sofosbuvir/NS5A inhibitor.

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In a study published today in the journal Cell, University of California, Irvine researchers reported that they have accelerated and simplified directed evolution by having live cells do most of the heavy lifting. By inserting a specially engineered DNA replication system into yeast, the scientists were able to coax selected genes to rapidly and stably mutate and evolve as the host yeast cells reproduced.

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A large-scale soil project uncovered genetic information from bacteria with the capacity to make specialized molecules that could lead to new pharmaceuticals.

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Loyola Medicine has announced that Shawn P. Vincent is the new president & chief executive officer of the regional system. He also is a member of the Loyola Medicine board of directors.

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Researchers with the Department of Energy’s Oak Ridge National Laboratory have discovered that communities of microbes living near tree roots are ten times more diverse than the human microbiome and produce a cornucopia of novel molecules that could be useful as antibiotics and anti-cancer drugs.

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The $200-million commitment will fund: o Fundamental curiosity-driven research and a therapeutics initiative to catalyze the development of new treatments o Integrated data science and artificial intelligence capabilities and applications o Cross-disciplinary research across the Harvard life sciences ecosystem o LifeLab Longwood, an incubator for early-stage, high-potential biotech start-ups In honor of the gift—the largest in Harvard Medical School history—the School will name a research institute for the donor to recognize the pioneering work of its basic science and social science departments.

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At-home blood sampling streamlines the process of therapeutic drug monitoring and creates comfort and emotional safety for children

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A new study by scientists from the University of Chicago shows how cyanobacteria, or bacteria that produce energy through photosynthesis like plants, change the way they grow and divide in response to different levels of light.

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There are over six million fractures per year in the U.S. with direct costs in the billions, not to mention lost productivity. The only drug currently available to accelerate the healing process must be applied directly onto the fracture surface during surgery, but not all breaks require such intervention. New research, Bone Fracture-Targeted Dasatinib Conjugate Potently Enhances Fracture Repair In Vivo, presented today at the 2018 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 Meeting highlights a novel bone anabolic agent that, when injected, intravenously reduces femur fracture healing time by 60 percent without impacting the surrounding healthy tissue.

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With the growing awareness of ultraviolet (UV) exposure resulting in an increased risk of photoaging and skin cancers, consumers are using higher sun protection factor (SPF) sunscreens with frequent reapplication. New research, Evaluation of Reapplication and Controlled Heat Exposure on Oxybenzone Permeation from Commercial Sunscreen Using Excised Human Abdominal Skin, presented today at the 2018 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 Meeting demonstrates that heat and reapplication influences different sunscreen products containing the same amount of a key ingredient, oxybenzone, potentially affecting safety and toxicity of the UV filters included in sunscreens.

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In the journal Obstetrics & Gynecology, researchers published the results of mailing at-home, HPV self-collection kits to 193 low-income women in North Carolina who were overdue for screening according to national guidelines.

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A new immunotherapy screening prototype developed by University of California, Irvine researchers can quickly create individualized cancer treatments that will allow physicians to effectively target tumors without the side effects of standard cancer drugs.

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Study shows deep learning models must be carefully tested across multiple environments before being put into clinical practice.

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Scientists at IMBA - Institute of Molecular Biotechnology at the Austrian Academy of Sciences - together with the Boston Children's Hospital at Harvard, demonstrate a completely new way of combating autoimmune diseases and cancer.

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A widely used naloxone nasal spray (NNS) and naloxone injection (NIJ), otherwise known as Narcan® and Evzio®, which are administered to prevent opioid overdose deaths, were found to be chemically stable up for at least ten months and beyond one year of the expiration date, respectively.

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Patient talks will inform scientists and clinicians on etiology and impact

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Young adults who are educated about dietary supplements in college are more likely to use them appropriately, according to new research from Binghamton University, State University at New York.

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Penn Medicine emergency department physicians are calling for more readily available testing strips to identify the presence of fentanyl in patients experiencing a drug overdose, and a rapid, coordinated response among health care providers and city agencies to help curb overdoses and identify high potency high risk drugs.

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November is C. diff awareness month, a time to focus on raising awareness about the prevention and treatment of Clostridium Difficile Infections. Mayo Clinic experts are available for interviews.

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New agreement between National Comprehensive Cancer Network and Syapse will augment health information technology around precision medicine and biomarkers in cancer care

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Researchers from the Icahn School of Medicine at Mount Sinai found that patients with Major Depressive Disorder (MDD) exhibited a significant reduction of depressive symptoms after being treated with ezogabine, an FDA approved drug used to treat seizures.

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Skeletal stem cells are valuable because it's thought they can heal many types of bone injury, but they're difficult to find because researchers don't know exactly what they look like or where they live.

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The early-stage, pilot trial aims to establish the safety of destroying a small target in the brain to treat chronic neuropathic pain.

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New method developed by Mount Sinai team allows systematic study of effects of a wide range of drugs on the developing fetus

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Children who are given antibiotics or antacids in their first two years of life are more likely to become obese during their childhood, according to a new study published today in the British Medical Journal, Gut.

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With more and more medical tests being performed outside the traditional clinical laboratory, AACC released a position statement today emphasizing the need to ensure consistent high-quality testing at non-traditional facilities such as physician offices and pharmacies. The statement urges Congress to direct the Department of Health and Human Services (HHS) to study testing at non-traditional sites and to recommend steps to ensure patients get consistently reliable results to facilitate effective treatment.

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Iowa State University veterinary researchers are working with the Food and Drug Administration to advance an innovative in vitro model to study the oral absorption of therapeutic drugs without requiring testing on live animals. The work could lead to more efficient and safer development of new therapies for human and animal medicine.

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The National Institutes of Health has awarded a Florida State University researcher nearly $2 million to investigate ketamine, which some have called a wonder drug, and its possible use in treating depression.

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AAPS Announces 2018 Distinguished Pharmaceutical Scientist Award

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ISPOR, the professional society for health economics and outcomes research (HEOR), released the final program and speakers for its upcoming ISPOR Europe 2018 conference scheduled for 10-14 November in Barcelona, Spain.

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Adding radiation therapy or surgery to systemic therapy for stage IV lung cancer patients whose cancer has spread to a limited number of sites can extend overall survival time significantly, according to new results from a multicenter, randomized, controlled phase II study. The findings were presented last week at the 60th Annual Meeting of the American Society for Radiation Oncology (ASTRO).

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Penn Medicine and Wharton are joining forces to launch an executive health care leadership program that will offer participants a strategic toolkit to cement their ability to lead at a time when science, technology, and economics are reshaping the practice of medicine.

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A study, which evaluated the prevalence and clinical consequences of prescription amphetamine (AMP) misuse among adolescents and adults, found severe medical outcomes occur when people snort or inject stimulant medication.

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Accreditation represents a big step in recognizing clinical research as an academic discipline

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Results of a phase II clinical trial show that novel drug sparsentan is an effective treatment for the rare kidney disease focal segmental glomerulosclerosis (FSGS), which currently has no FDA-approved therapies.

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Wilfred Chen will receive the 2018 American Institute of Chemical Engineers (AIChE) Food, Pharmaceutical and Bioengineering Division Award in Chemical Engineering at the 2018 AIChE Annual Meeting.

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Université de Montréal researchers are able to see how frontline diabetes drug metformin alters cell glucose uptake using new technology that probes how drugs act on all cellular functions.

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A University of Adelaide forensic pathologist is warning that potentially harmful substances found in herbal medicines may be playing a bigger role in deaths of ‘health tourists’ than previously thought.

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CEO of the nation's nearly 53,000 Certified Registered Nurse Anesthetists(CRNAs) has worked with both political parties and chambers of Congress to be part of the solution to the opioid crisis. CRNAs administer more than 45 million anesthetics to patients each year.

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Rush University Medical Center has received a $5 million donation from Chicago philanthropists Robert and Emily King that will accelerate blood cancer immunotherapy research and the development of new treatment options. This transformational gift to the Rush University Cancer Center is expected to heavily increase much-needed early-stage clinical trials at Rush over the next five years, the kind of research that is essential in developing lifesaving treatments or even a cure.

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New Program Designed to Break Down Barriers to Breast Cancer Screening

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Aunque casi todos los estadounidenses dicen que optarían por una alternativa a los opioides para aliviar el dolor después de una cirugía, pocos pacientes hablan al respecto con sus proveedores de atención médica, informa la Revisión nacional de la salud por parte de Mayo Clinic.

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Multiple myeloma doesn’t play around. Within five years of being diagnosed with this form of blood cancer, about half of all patients die from it. And even if they initially respond well to treatment, the cancer can hide in their bone marrow for years before reemerging in a tougher-to-treat form.

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Embora quase todos os americanos digam que escolheriam uma opção alternativa ao opioides para alívio da dor no pós-operatório, poucos pacientes discutem essa questão com os médicos, de acordo com a Avaliação nacional de saúde da Mayo Clinic.

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Value in Health, the official journal of ISPOR (the professional society for health economics and outcomes research), announced today the publication of new research showing that Medicare Part D prescription plans with higher generic drug use have higher summary star ratings and improved member experience.