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Markus Seeliger, Ph.D., Assistant Professor, Department of Pharmacological Sciences, Stony Brook University School of Medicine, and collaborators at Harvard University, have developed and characterized the mechanism of a new class of highly specific inhibitors of the Src (sarcoma) kinase, known as a cancer-causing protein. The research, published in the April 2012 edition of Nature Chemical Biology, may provide a foundation to developing new targeted cancer therapeutics.

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Sugary drinks are the single biggest contributor to the obesity epidemic in the United States, and according to the Centers for Disease Control, two-thirds of adults and one-third of the children in the U.S. are overweight or obese. Registered dietician Leah Holbrook, Coordinator of the Long Island Center for Pediatric Obesity Prevention in the Department of Family Medicine at Stony Brook School of Medicine, says that these sobering statistics and the fact that beverages account for nearly half of the added sugars in our diet are a wakeup call for Americans to reduce their sugary drink intake.

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A study of more than 300 children and adolescents with human immunodeficiency virus (HIV) revealed no association between specific antiretroviral therapy and the severity of psychiatric disorders. In “Human Immunodeficiency Virus Disease Severity, Psychiatric Symptoms, and Functional Outcomes in Perinatally Infected Youth,” Principal Investigator Sharon Nachman, M.D., of Stony Brook School of Medicine, and colleagues detail this finding and others in the Online First edition of Archives of Pediatrics & Adult Medicine.

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– A clear association between obesity and pain – with higher rates of pain identified in the heaviest individuals – was found in a study of more than one million Americans published January 19 in the online edition of Obesity. In “Obesity and Pain Are Associated in the United States,” Stony Brook University researchers Arthur A. Stone, PhD., and Joan E. Broderick, Ph.D. report this finding based on their analysis of 1,010,762 respondents surveyed via telephone interview by the Gallop Organization between 2008 and 2010.

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Talking on a cell phone or texting while walking may seem natural and easy, but it could be dangerous and result in walking errors and interfere with memory recall. Researchers at Stony Brook University found this to be the case in a study of young people walking and using their cell phones. The study is reported in the online edition of Gait & Posture.

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The Stony Brook University World Trade Center Health Program is expanding its clinical Center of Excellence to Winthrop-University Hospital which enables care and treatment for thousands more who were exposed to toxic chemicals and who continue to suffer from upper and lower respiratory ailments, mental health symptoms, and other conditions related to the environment at Ground Zero.

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For children with HIV infection, the Food and Drug Administration (FDA) approval of the use of raltegravir, an antiretroviral drug that slows the spread of HIV infection, offers a new weapon to treat HIV infection in children.

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More than 10 years after 9/11, when thousands of rescue and recovery workers descended on the area surrounding the World Trade Center in the wake of the terrorist attacks, a research team led by Benjamin J. Luft, M.D., the Edmund D. Pellegrino Professor of Medicine, and Medical Director of Stony Brook’s World Trade Center Health Program, and Evelyn Bromet, Ph.D., Distinguished Professor, Departments of Psychiatry and Behavioral Science, and Preventive Medicine, Stony Brook University School of Medicine, has published results of a study examining the relationship between the two signature health problems among WTC first responders—respiratory illness and post-traumatic stress disorder (PTSD).

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Giving during the holidays, or at any time, not only helps others but helps ourselves and appears to lead to a happier and healthier life. This conclusion by Stephen G. Post, Ph.D., Professor of Preventive Medicine, Head of the Division of Medicine in Society, and Director, Center for Medical Humanities, Compassionate Care and Bioethics, Stony Brook University School of Medicine, is based on a review of scientific and medical studies covering several decades on the benefits experienced by individuals who act sincerely for the benefit of others.

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Guedalia Sawadogo, a 2-year-old girl from West Africa, enjoys drawing with a pen and playing with figurines shaped as people or animals. During a hand therapy session at Stony Brook University Hospital she could only use her left hand for those activities, as her recent surgically repaired right hand went through the rigors of adjusting to a splint. But soon with more healing Guedalia will have the dexterity of normal children to play and learn. On November 14, Alexander Dagum, M.D., Professor of Surgery and Orthopaedics, and Chief, Division of Plastic and Reconstructive Surgery at Stony Brook University School of Medicine, performed surgery on Guedalia’s right hand to correct contractures caused by scar tissue healing after a serious burn injury.

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Aristolochic acid, a component of a plant used in herbal remedies since ancient times and still used in certain herbal medicines worldwide, leads to kidney failure and upper urinary tract cancer in those exposed to the toxin.

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Benjamin J. Luft, M.D., Edmund D. Pellegrino Professor of Medicine at Stony Brook University School of Medicine, and Medical Director of Stony Brook’s World Trade Center Health Program, will present “We’re Not Leaving: Responders Oral Histories Redefine 9/11,” at the American Folklife Center at The Library of Congress in Washington, D.C., on November 10. The Center will serve as the repository for oral histories of 9/11 first responders from around the country, which are being recorded and filmed by Dr. Luft and the WTC Health Program staff as the Remembering 9/11 oral history project. The lecture will be held in the Mary Pickford Theater, from 12:00 noon to 1:00 p.m.

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Stony Brook University has launched a pilot epidemiologic study targeting avid fish consumers that will examine the benefits and risks of seafood consumption. The “Long Island Study of Seafood Consumption,” led by Jaymie Meliker, Ph.D., Assistant Professor, Graduate Program in Public Health, Department of Preventive Medicine, Stony Brook University School of Medicine, is now recruiting for study participants via a qualifying survey.

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Stony Brook University Medical Center has opened a new Valve Center that offers comprehensive treatment of valvular heart disease.

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Specialists in Stony Brook University School of Medicine took part in a NIH-sponsored clinical trial that reveals high-risk patients without stents implanted had fewer second strokes.

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Allen Jeremias, M.D. has been named one of 10 national fellows for the inaugural Society for Cardiovascular Angiography and Interventions (SCAI) Emerging Leader Mentorship (ELM) Program.

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Interventional cardiologists at the Stony Brook University Heart Center and elsewhere are performing more heart catheterizations by going through the wrist instead of the groin. This approach has increased advantages for patients.

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By employing optogenetics, a new field that uses genetically altered cells to respond to light, researchers at Stony Brook University have demonstrated a way to control cell excitation and contraction in cardiac muscle cells.

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Inpatient hospitalizations for children and adolescents with a psychiatric diagnosis increased significantly over a 12-year period (1996 to 2007), according to a report in the early online edition in Archives of General Psychiatry.

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A Stony Brook University School of Medicine study concludes that there do not appear to be any negative associations between bedsharing in toddlerhood and children’s behavior and cognition at age 5.

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Stony Brook University Hospital was named as one of America’s Most Beautiful Hospitals, ranking third in a list of 50 healthcare facilities around the country. Soliant Health, a leading specialty healthcare provider, released the results this month of the 20 Most Beautiful Hospitals 2011, a contest developed by Soliant Health.

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Researchers in the Department of Pathology at Stony Brook University School of Medicine have discovered a laboratory method to expand adult hematopoietic stem cells (HSCs) using the SALL4 gene.

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As more and more children participate in a single sport on a year-round basis, these young athletes are increasingly at risk for overuse injuries. Additionally, concussions have become a major cause for concern among youth sports participants.

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The first Stony Brook University and Brookhaven National Laboratory Clinical Research Day will be held on May 13 at Stony Brook University Medical Center.

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A new study shows that levels of rape and sexual violence against women in the Democratic Republic of Congo are 26 times higher than official United Nations estimates.

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In an analysis of more than 1,300 human breast tissue samples, Stony Brook University School of Medicine researchers discovered a possible role of the squamous cell carcinoma antigen in the progression of breast cancer.

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Ann Jillian, a Golden Globe-winning, three-time Emmy-nominated actress and singer, will be the keynote speaker at the seventh annual National Cancer Survivors Day® at the Cancer Center at Stony Brook University Medical Center.

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In a study on the relationship between unemployment and the risk of death, researchers found that the risk of death was 63% higher in those who experienced an episode of unemployment than those who did not.

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Hospital admissions at Stony Brook University Medical Center were significantly reduced when using coronary computed tomographic angiography (CCTA) to evaluate Emergency patients with chest pain.

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Michael Frohman, M.D., Ph.D., Chair of the Department of Pharmacological Sciences at Stony Brook University School of Medicine, and colleagues, have discovered a new role for mitochondria during RNA processing.

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The Stony Brook University School of Dental Medicine is leading a multicenter National Institutes of Health-sponsored clinical trial to evaluate whether treatment of chronic periodontitis will help improve diabetes control.

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Cancer patients treated with the chemotherapy agent bevacizumab (Avastin) may be at an increased risk of treatment-related death when the drug is used in combination with other therapies.

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Hundreds came out to support 17-year ALS survivor Christopher Pendergast, at a ceremony marking the renaming of Stony Brook University Medical Center’s ALS clinic to the Christopher Pendergast ALS Center of Excellence.

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Stony Brook University Medical Center has received the 2009 American Heart Association/American Stroke Association’s Get With The Guidelines Stroke Gold Plus Performance Achievement Award.

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Stony Brook University Medical Center celebrates new expanded clinical and research center for acute stroke, brain aneurysms, AVMs and other vascular anomalies and unveils one-of-a kind simulator that will help advance clinical expertise, teaching and research for neurosciences at Stony Brook University.

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For Chris Pendergast, every Christmas he has been alive to celebrate with his family for the past 17 years has been a gift unto itself. Indeed, in 1993 the then 44-year-old elementary school teacher was diagnosed with ALS.

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A study of nearly 1,200 older patients hospitalized for severe sepsis indicate that those who survive are at higher risk for long-term cognitive impairment and physical limitations than those hospitalized for other reasons.

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What do Aerosmith lead guitarist Joe Perry and rock stars have in common with research scientists? According to some rock stars and those at an international gathering of researchers and bioscience executives, a lot.

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Balaji Sitharaman, Ph.D., of Stony Brook University, is a recipient of the NIH Director’s New Innovator Award. He is engineering a nanotechnology-based theranostic for combined non-invasive imaging and treatment of bone loss.

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Danny Bluestein, Ph.D., of Stony Brook University, has been awarded a $7.5 million grant by the NIH to optimize the designs of cardiovascular devices with the goal to eliminate the need for anticoagulation therapy.

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Benjamin Luft, M.D., Professor of Medicine, Stony Brook University Medical Center, and a team of medical researchers have determined the genetic blueprint of 13 strains of the bacteria that cause Lyme disease.

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Researchers at Stony Brook University have discovered that a derivative of sulindac, an NSAID known to prevent colon cancer, is more effective and safer than sulindac in preventing colon cancer in animals.

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Almost half of children with ADHD whose aggressive behaviors had not been controlled during routine outpatient care could achieve near absence of aggressive, explosive behavior with "first-line" stimulants.

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Dr. Kevin Watkins, first Surgeon to treat Pancreatic Cancer with NanoKnife® helps patients from around the country; world.

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The School of Social Welfare at Stony Brook University is sponsoring an innovative Geriatric Care Ministry Program to help clergy of all faiths improve the quality-of-life for older people in their communities.

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Three-dimensional MRI is an emerging and useful technique for displaying fetal anatomy and diagnosing problems in the womb, according to Jeffrey C. Hellinger, M.D., of Stony Brook University Medical Center.

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Ensuring the safety of pediatric cardiovascular and vascular patients who require computed tomographic angiography (CTA) for diagnostic purposes means that employing methods of low dose CTA is essential.

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Fossils of an ancient crocodile with mammal-like teeth discovered in the Rukwa Rift Basin of Tanzania is changing the picture of animal life at 100 million years in what is now sub-Saharan Africa.

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Strengthening certain aspects of a new and evolving model of comprehensive and coordinated primary care could potentially address why errors in diagnosis place a heavy financial burden on an already costly health care system.

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A team of molecular biologists and computer scientists at Stony Brook University have used a novel method to weaken influenza virus by designing hundreds of mutations to its genetic code to create an effective vaccine.