Latest News from: SLAS

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Released: 29-Jan-2019 10:05 AM EST
OCTN: A Small Transporter Subfamily with Great Relevance to Human Pathophysiology, Drug Discovery and Diagnostics
SLAS

A new review by researchers from the University of Calabria (Italy) explores OCTNs, a small but intriguing group of transporters that are opening new frontiers in drug design research for improving drug delivery and predicting drug-drug interactions.

   
Released: 24-Jan-2019 10:05 AM EST
Announcing the 2018 SLAS Technology Ten: Translating Life Sciences Innovation
SLAS

The SLAS Technology Ten annually showcases ten individual articles that stand out as the most innovative scientific achievements published in SLAS Technology in the past 12 months.

   
Released: 17-Jan-2019 3:05 AM EST
Advances in 3D and Organoid Cell Culture
SLAS

A new collection of reviews and original research illustrate how new technologies and advanced cell culture are accelerating basic research, drug discovery and drug development.

   
Released: 28-Nov-2018 5:05 AM EST
Improved Fluorescence Methods for High-Throughput Protein Formulation Screening
SLAS

A study demonstrates the feasibility of using a steady-state/lifetime fluorescence plate reader for direct optimization of challenging formulation conditions and highlights the importance of performing formulation optimization under commercially relevant conditions.

   
Released: 26-Nov-2018 3:05 PM EST
Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?
SLAS

Researchers from the University of Manchester explore recent developments and strategies for targeting the NLRP3 inflammasome as a potential therapeutic target in acute and chronic neurological and neurodegenerative diseases, and offer perspective on how this field may develop in the future.

   
21-Sep-2018 5:05 AM EDT
Harnessing Artificial Intelligence to Improve Drug Combination Design and Personalized Medicine
SLAS

A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.

17-Sep-2018 3:05 PM EDT
Advancing Life Sciences Research with the Internet of Things
SLAS

The internet of things (IoT) is allowing scientists to optimize laboratory operations and combine instruments to measure and respond to complex experimental conditions. As a result, IoT is enabling more detailed and more complex experimental designs.

   
6-Sep-2018 5:05 AM EDT
Screening Strategies and Methods for Better Off-Target Liability Prediction and Identification of Small-Molecule Pharmaceuticals
SLAS

A new review explores how improved safety screening strategies and methods are improving the pharmaceutical discovery and development process. The authors outline several fundamental methods of the current drug screening processes and emerging techniques and technologies that promise to improve molecule selection. In addition, the authors discuss integrated screening strategies and provide examples of advanced screening paradigms.

   
Released: 24-Jul-2018 6:05 AM EDT
High-Throughput Flow Cytometry in Drug Discovery
SLAS

A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.

   
Released: 23-Jul-2018 11:05 AM EDT
Enabling Technology in Cell-Based Therapies: Scale-Up, Scale-Out or Program In-Place
SLAS

Technologies that are reducing costs and changing the ways in which researchers and clinicians process and use therapeutic cells are showcased in the August 2018 special issue of SLAS Technology.

25-Jun-2018 7:05 AM EDT
Platforms for Investigating LncRNA Functions
SLAS

To aid in the discovery and understanding of lncRNA biology, newly published work features the technological platforms and methodology presently used to identify the roles of lncRNA in biology. This work highlights the databases and tools used to study lncRNA and techniques used to study their function.

   
18-Jun-2018 9:05 AM EDT
Using Fragment-Based Approaches to Discover New Antibiotics
SLAS

A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.

   
Released: 20-Jun-2018 3:05 AM EDT
Integrated Lead Discovery: An Evolving Toolbox
SLAS

A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.

   
30-May-2018 1:05 AM EDT
Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development
SLAS

Researchers share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.

   
24-May-2018 8:05 AM EDT
The Evolution in Flow Cytometry: Turning a Low-Throughput Platform into an Automated High-Throughput System
SLAS

New research highlights a diversity of approaches that an automated high-throughput flow cytometry has enabled for phenotypic drug discovery.

   
15-May-2018 8:05 AM EDT
Simplifying Skin Disease Diagnosis with Topical Nanotechnology
SLAS

This vision of simplifying disease diagnosis using topically-applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed.

   
1-May-2018 5:05 AM EDT
Auto-Commentary by the Authors of “LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle”
SLAS

In a new SLAS Discovery auto-commentary, two authors of an article recently published in eLife (“LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle”) explain their general views on their novel discoveries and discuss ideas on the relevant new questions generated by their data.

   
16-Apr-2018 5:05 AM EDT
Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening
SLAS

A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled "Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening," the report can be accessed for free.

   
2-Apr-2018 3:05 AM EDT
Automated Preparation of MS-Sensitive Fluorescently-Labeled N-Glycans with a Commercial Pipetting Robot
SLAS

A new original research report available ahead-of-print at SLAS Technology demonstrates the semi-automation of a GlycoWorks RapiFluor-MS (RFMS) Kit using a pipetting robot to improve life sciences research productivity.

Released: 22-Mar-2018 4:05 AM EDT
Fully Automated Pipetting Sorting System for Different Morphological Phenotypes of Zebrafish Embryos
SLAS

Breitwieser and colleagues of the Karlsruhe Institute of Technology (Germany) describe a fully automated high-throughput sorting system for zebrafish embryo phenotypes that benefits high-throughput screening by saving time and improving accuracy.

   
16-Mar-2018 5:05 AM EDT
Protein Nutrition for Cells and Organisms: Can We Use it to Treat Diseases?
SLAS

A review article by Prof. Stefan Broer, Ph.D., highlights opportunities and challenges in using amino acid transporters as drug targets. Amino Acid Transporters as Disease Modifiers and Drug Targets provides an overview of methods used to identify new inhibitors for amino acid transporters and outlines cell and organ function where these can be used to modulate, prevent or to treat diseases.

   
15-Feb-2018 5:05 AM EST
Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective
SLAS

A perspective article in the March 2018 issue of SLAS Discovery from the biology group at the European Screening Centre Newhouse details how the European Lead Factory (ELF), a large publicly accessible drug discovery platform, uses microscale thermophoresis (MST) to aid in the prioritization of small molecule hits from high-throughput screening.

   
2-Feb-2018 6:05 AM EST
SLAS Scientific Journals Honor Achievement by Authors and Reviewers
SLAS

SLAS Discovery (formerly the Journal of Biomolecular Screening) and SLAS Technology (formerly the Journal of Laboratory Automation), both published by SLAS (Society of Laboratory Automation and Screening) in partnership with SAGE Publishing, hosted a special reception to celebrate the 2018 SLAS Journal Achievement Award honorees on Feb. 6 at SLAS2018, the SLAS International Conference and Exhibition, held Feb. 3-7, 2018, in San Diego, CA.

   
Released: 29-Jan-2018 9:05 AM EST
A Phenotypic High-Throughput Screen to Identify Modulators that Improve Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity
SLAS

A phenotypic high-throughput screen to identify modulators that improve mutant cystic fibrosis transmembrane conductance regulator (CFTR) activity is described in the SLAS Discovery February 2018 front cover feature article by Giuliano and colleagues of Proteostasis Therapeutics, Inc. (Cambridge, MA).

   
Released: 24-Jan-2018 6:05 AM EST
Announcing the 2018 SLAS Technology Ten: Translating Life Sciences Innovation
SLAS

“The 2018 SLAS Technology Ten represent some of the most innovative scientific achievements that were featured in SLAS Technology in the past 12 months,” says Editor-in-Chief Edward Kai-Hua Chow, PhD (National University of Singapore).

   
16-Jan-2018 9:00 AM EST
Developing the VTX-1 Liquid Biopsy System: Fast and Label-Free Enrichment of Circulating Tumor Cells
SLAS

A new article in the February 2018 issue of SLAS Technology describes a new platform that could change the way cancer is diagnosed and treated by automating the isolation of circulating tumor cells (CTCs) directly from cancer patient blood. The article provides unique insight into the development of a commercial system that has the potential to change the standard of care in cancer diagnosis and treatment.

11-Jan-2018 7:05 AM EST
A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities
SLAS

A new original research article in SLAS Discovery presents a fast, sensitive, and robust methodology for screening small molecule inhibitors against CD73/Ecto-5’-Nucleotidase, a promising target for developing anti-cancer drugs.

   
Released: 21-Dec-2017 9:05 AM EST
A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase
SLAS

An original research report by Eun Jeong Cho et al. (University of Texas at Austin) in the January 2018 Issue of SLAS Discovery presents a newly designed biochemical assay that is rapid, sensitive, inexpensive, and high-throughput screening (HTS)-friendly to identify antagonist against aldolase A (ALDOA).

   
19-Dec-2017 7:05 AM EST
Nanofractionation Platform with Parallel Mass Spectrometry for Identification of Cytochrome CYP1A2 Inhibitors in Metabolic Mixtures
SLAS

This new (and freely available) original research article presents a fast, robust and accurate methodology for correlating compound identity to CYP1A2 potency of inhibitors in metabolic mixtures. The methodology is centered around an at-line nanofractionation platform in which a metabolic mixture is chromatographically separated followed by parallel on-line mass spectrometric (MS) analysis and at-line nanofractionation on high-density microtiter well plates that are then directly exposed to a bioassay.

   
12-Dec-2017 3:05 AM EST
Bioluminescent Succinate Detection for Monitoring the Activity of Dioxygenases and JMJC Demethylases
SLAS

A new (and freely available) original research article published ahead-of-print at SLAS Discovery Online describes a new methodology that enables the investigation of a large number of structurally conserved enzymes belonging to the Fe(II)/2-oxoglutarate-dependent dioxygenase superfamily.

   
Released: 28-Nov-2017 7:05 AM EST
Advances in MALDI Mass Spectrometry within Drug Discovery
SLAS

SLAS Discovery marks the 30th anniversary of Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI TOF), the soft ionization technique for analyzing non-volatile biomolecules using mass spectrometry, with a special issue showcasing 10 new research reports.

   
Released: 22-Nov-2017 6:05 AM EST
Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing
SLAS

A review article in the December 2017 issue of SLAS Technology provides important information for life sciences and technology professionals in academia and industry and members of the general public who are interested in antibiotic resistance, general microbial detection principles, in vitro diagnostics, micro- and nanotechnologies, and next generation rapid microbial testing methods.

   
6-Nov-2017 9:05 AM EST
Theranostic Nanoparticles for Tracking and Monitoring Disease State
SLAS

A new SLAS Technology review article by researchers at the University of Southern California and the University of California, Los Angeles, sheds light on the growing number and more sophisticated designs of theranostic nanoparticles.

   
Released: 1-Nov-2017 3:05 AM EDT
In Vitro Tissue Microarrays for Quick and Efficient Spheroid Characterization
SLAS

A new SLAS Discovery article available for free ahead-of-print enables researchers to derive more clinically-relevant information from 3D cell culture models.

   
26-Sep-2017 2:00 AM EDT
New Approaches to Difficult Drug Targets: The Phosphatase Story
SLAS

Discovering new drugs has never been easy and some potential drug targets have historically been viewed as too challenging and thus off limits for prosecution. In a new SLAS Discovery review, authors John S. Lazo et al. of the University of Virginia reflect on the nature of protein tyrosine phosphatases and explores reasons why these enzymes have been eschewed by drug hunters, and how the landscape is beginning to change.

   
21-Sep-2017 2:00 AM EDT
Heart-on-a-Chip: Influence of Static and Perfusion on Cardiac Cells
SLAS

A new report shows how microsystems can be used to understand processes in heart tissue in detail and to test newly developed compounds applied in the treatment of cardiac diseases.

   
23-Aug-2017 2:05 AM EDT
New Therapeutic Targets for Osteoarthritis Pain
SLAS

An exploration of the latest understanding of the complex mechanisms behind OA pain offers new possibilities and potential treatment targets for osteoarthritis (OA) pain. New areas of research discussed include the use of combination therapies and the development of biomarkers to target effective pain treatment.

   
Released: 21-Jul-2017 1:05 AM EDT
Micro- and Nanotechnologies for Quantitative Biology and Medicine
SLAS

Ten new reviews and original research reports that illustrate how the progression of research assays from qualitative outputs toward increasingly sensitive quantitative outputs is transforming life sciences and biomedical research and diagnostics by improving the ability of researchers and clinicians to detect and quantify increasingly complex assays.

   
Released: 19-Jul-2017 1:05 AM EDT
Control of the Unfolded Protein Response in Health and Disease
SLAS

This new review in SLAS Discovery analyzes the recent literature and impact of unfolded protein response (UPR) in health and disease.

   

Showing results 101–139 of 139


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