The research team has discovered that for acute myeloid leukemia (AML) patients, there is a dopamine receptor pathway that becomes abnormally activated in the cancer stem cells. This inspired the clinical investigation of a dopamine receptor-inhibiting drug thioridazine as a new therapy for patients, and their focus on adult AML has revealed encouraging results.
The McMaster research team is partnering with research clinic Cardresearch and the Pontifical Catholic University of Minas Gerais in Brazil as well as the University of Stellenbosch in South Africa on an ongoing clinical trial established to answer multiple questions of drug effectiveness over time.
Neuroscientists at McMaster University have found a link between children who are at risk for developmental coordination disorder (DCD), a common condition that can cause clumsiness, and difficulties with time perception such as interpreting changes in rhythmic beats.
Researchers at Canada's McMaster University have established in lab settings that a novel combination of two forms of immunotherapy can be highly effective for treating lung cancer, which causes more deaths than any other form of cancer.
For the study 40 infants of women diagnosed with postpartum depression were matched with 40 infants of non-depressed mothers on infant age, gender and socioeconomic status. The mothers with postpartum depression received nine weeks of group CBT. The infants were all tested before the treatment and nine weeks later, including a questionnaire on the infant behaviour completed by the mother and her partner.
Researchers at Canada's McMaster University have developed a new form of cultivated meat using a method that promises more natural flavour and texture than other alternatives to traditional meat from animals.
A team of neuroscientists and engineers at McMaster University has created a nasal spray to deliver antipsychotic medication directly to the brain instead of having it pass through the body.
The mysterious death of a young, 18th century socialite has inspired a research project which could yield new information about the dangers of lead exposure.
An international team, including Canadian researchers from the University of Calgary and McMaster University, has discovered stone tools in Tanzania dating back 2 million years, the oldest evidence of human activity in what is known as the Cradle of Humankind.
Funded by a McMaster University, Department of Family Medicine, Pilot Research Project Funding Grant, the observational study is one of the few person-centered palliative care studies focused on the South Asian community outside India. The results showed that seventy per cent of participants in the study had a lack of understanding of palliative care and forty-four per cent thought that palliative care went against their values and beliefs.
Kinesiologists at McMaster University who examined the effectiveness of old-school physical training have found that simple bodyweight exercises, when performed vigorously over short periods, improve cardiorespiratory fitness.
Researchers from McMaster University have studied and analyzed thousands of weekly records documenting the deaths of smallpox victims in London, England over the span of nearly 300 years. The analysis provides new and rare insights into the ecology of infectious disease, establishing that the time between epidemics, the size of the outbreaks, and even the season when the epidemics occurred, changed over the centuries.
The study found that between March 1 and Sept 24, 2020, 92 per cent of resident and staff infections occurred at 10 per cent of retirement homes. During that time there were 172 retirement home outbreaks involving 1,045, or 1.9 per cent, of residents and 548, or 1.5 per cent) of staff. Fifty-one retirement homes had one or more of the 215 resident deaths.
Called PCSK9Q152H, the mutation of the PCSK9 gene was initially thought to protect against cardiovascular diseases. Recent studies reveal that it may protect against other human illnesses, mainly liver diseases. It may allow the PCSK9Q152H mutant subjects to stay in good health and live longer, the researchers say in a study published today in the prestigious Journal of Clinical Investigation.
The information came from the International Polycap Study 3 (TIPS-3) study which followed the participants an average of 4.6 years. The study of 5,714 people from nine countries, particularly India and the Philippines, looked at the polypill alone compared to a placebo; aspirin alone versus a placebo, and the polypill plus aspirin versus a double placebo. The men in the study were 50 or older and the women were 55 or older.
McMaster University has been awarded $2.5 million from the Government of Canada to support the McMaster HealthLabs (MHL) Canadian International COVID-19 Surveillance Border Study at Toronto Pearson International Airport, being run in partnership with Air Canada and the Greater Toronto Airports Authority (GTAA).
An international team of researchers led by McMaster University has found that tryptophan, an amino acid present in high amounts in turkey, along with some probiotics, may help them heal and respond better to a gluten-free diet. The findings highlight the potential therapeutic value of targeting tryptophan metabolism in the gut in celiac disease to better control symptoms, despite the gluten-free diet, and accelerate intestinal healing.
Researchers at McMaster University have found distinct effects of adversity early in life in the genomes of men compared to women who were born extremely preterm.
Researchers at Canada's McMaster University and SQI Diagnostics have created a surface that repels every other element of human blood except a critical indicator of infection, opening a timely window for understanding the progress of COVID-19 in individual patients.
McMaster University researchers who analyzed thousands of documents covering a 300-year span of plague outbreaks in London, England, have estimated that the disease spread four times faster in the 17th century than it had in the 14th century.
Researchers at McMaster and Brock universities have created the prototype for a hand-held device to measure a biomarker for cancer, paving the way for home-based cancer monitoring and to improve access to diagnostic testing.
The collaborate will bring together researchers, clinicians, educators and partners to work on issues that will address the diverse needs of our community, including bringing paramedics into subsidized housing, prison health research, indigenous teaching through art, bringing trained volunteers into the homes of older adults, studying how to reduce the number of unnecessary medications a patient takes, and more.
An international team led by current and former McMaster University researchers has developed an artificial lung to support pre-term and other newborn babies in respiratory distress.
Researchers at McMaster University have developed a new technique to tease ancient DNA from soil, pulling the genomes of hundreds of animals and thousands of plants – many of them long extinct – from less than a gram of sediment.
New research from an international team of evolutionary geneticists, bioinformaticians and paleontologists suggests that dramatic environmental changes accompanying the shift or melting of continental glaciers played a key role as American mastodons moved north from their southern ranges.
Research published today has identified a small molecule compound that can activate the Wnt pathway in non-Wnt subtypes of medulloblastoma, making these aggressive forms of cancer more responsive to therapies.The work also found the Wnt pathway, which has historically been considered cancer-promoting, to function as a cancer inhibitor in certain contexts.
Systematic reviews and meta-analyses demonstrate that opioids fail to achieve important benefits beyond alternative interventions with less harm.
Previously, scientists have determined that entry of SARS-CoV-2 into cells occurs through a receptor on the cell surface, known as ACE2. But the McMaster-Waterloo team has found that the ACE2 receptor is at very low levels in human lung tissue.
Researchers studying the mystery of why some weightlifters’ muscles grow much more quickly than others’ have found new answers through a novel experiment in which subjects worked out one leg and immobilized the other.
A collaboration led by the Royal Ontario Museum (ROM) and McMaster University has led to the discovery and diagnosis of an aggressive malignant bone cancer — an osteosarcoma — for the first time ever in a dinosaur. No malignant cancers (tumours that can spread throughout the body and have severe health implications) have ever been documented in dinosaurs previously. The paper was published August 3rd in the prestigious medical journal The Lancet Oncology.
The review found among children who were infected, transmission was traced back to community and home settings or adults, rather than amongst children within daycares or schools even in jurisdictions where schools remained open or have since reopened.
Scientists and historians working at McMaster University, the Mütter Museum and the University of Sydney have pieced together the genomes of old viruses that were used as vaccination strains during and after the American Civil War ultimately leading to the eradication of smallpox.
Toyota Tsusho Canada, Inc. (“TTCI”) will team up with McMaster engineers and biochemists to move a promising new food-safety technology from the lab to the marketplace.
Based on randomized control trials, the systematic review and analysis revealed that cognitive behavioural therapy that connected therapists and patients through such modes as web-based applications, video-conferencing, email and texting, improved patients’ symptoms better than face to face when measured using standardized mood symptoms scales. As well, there was no difference in the level of satisfaction or function between the two methods of delivery.
Researchers at McMaster University who study how the brain processes sound have discovered the common practice of using artificial tones in perception experiments could mean scientists are overlooking important and interesting discoveries in the field of brain research
A team of underwater cave explorers in Mexico have made unprecedented archeological discoveries in some of the most inaccessible places on Earth that unlock key mysteries about the earliest inhabitants of the Western Hemisphere, according to international experts who have studied the sites.
Research from the Department of Kinesiology at McMaster University has found that the practical advantages of high-intensity interval training (HIIT), or short bursts of all-out exercise, could be especially beneficial for people who have experienced spinal cord injuries (SCI).
An international team of researchers led by McMaster University has found that while higher heat and humidity can slow the spread of COVID-19, longer hours of sunlight are associated with a higher incidence of the disease, in a sign that sunny days can tempt more people out even if this means a higher risk of infection.
he systematic review was conducted by a large, international collaborative of researchers, front-line and specialist clinicians, epidemiologists, patients, public health and health policy experts of published and unpublished literature in any language.
The research team conducted the patient survey between November 2018 and February 2019 at the Robert Schad Naturopathic Clinic in Toronto. Based on 277 completed questionnaires, 99 per cent of the patients surveyed were using natural health products, and 46 per cent were using natural health products and prescription medications concurrently. Of those using natural health products, 42 per cent did not disclose use to their primary care physician.
In this study, researchers investigated if specific targeting of CD133+ glioblastoma with cutting-edge immunotherapy drugs could eradicate the most aggressive subpopulation of cells in the tumour. They also looked at the safety of CD133-targeting therapies on normal, non-cancerous human stem cells including hematopoietic stem cells which create blood cells and progenitor cells which can form one or more kinds of cells.
Glass frogs are well known for their see-through skin but, until now, the reason for this curious feature has received no experimental attention.
The international research team examined a century of evidence including recent data, and found strong evidence showing that cloth and cloth masks can reduce contamination of air and surfaces.
The information came from the Prospective Urban Rural Epidemiological (PURE) study which followed the participants an average of 10 years.
A team of researchers at McMaster University has developed a reliable and accurate blood test to track individual fat intake, a tool that could guide public health policy on healthy eating.
Researchers found that co-administering dephostatin and colistin in mice with a lethal Salmonella infection significantly prolonged animal survival and used a lower concentration of colistin than is normally required for treatment, thereby reducing its toxic effect.
A systematic review and meta-analysis has determined there is a nine-fold increased risk of having IBD for patients with a previous diagnosis of celiac disease. Similarly, the risk for celiac disease is increased in IBD patients, though to a smaller extent.
A group of 59 international scientists, led by researchers at Canada’s McMaster University, has uncovered new information about the distinct effects of climate change on boreal forests and peatlands, which threaten to worsen wildfires and accelerate global warming.
The research team conducted a prospective cohort study focused on Canadian chiropractors’ websites between July 2016 and April 2019. Researchers revisited all identified websites from 2016 in April 2019 to explore changes to posted vaccination material.
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